Improved dispersibility of nano-graphene oxide by amphiphilic polymer coatings for biomedical applications

Imani, Rana; Shao, Wei; Emami, Shahriar Hojjati; Faghihi, Shahab; Prakash, Satya

doi:10.1039/c6ra15531f

Cited by 20 publications

(11 citation statements)

References 32 publications

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“…To overcome these obstacles, numerous types of biological or synthetic polymers, such as hyaluronic acid derivatives, dextran, heparin, polyethylene glycol (PEG), phospholipid-polyethylene glycol, polystyrene- co -poly(acrylic acid), and polystyrene- co -poly 4-vinylpyridin, have been utilized for coating rGO nanosheets. Although, all these surface molecules increase the stability of rGO in aqueous media they are not optimized for targeted delivery to tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…21,27 Despite the promising properties of rGO for photothermal therapy applications, the use of rGO has been limited by low stability in aqueous media due to the absence of surface hydrophilic groups. 28−32 To overcome these obstacles, numerous types of biological or synthetic polymers, 33 such as hyaluronic acid derivatives, 34 dextran, 22 heparin, 35 polyethylene glycol (PEG), 36 phospholipid-polyethylene glycol, 37 polystyrene-co-poly(acrylic acid), 37 and polystyrene-co-poly 4-vinylpyridin, 37 have been utilized for coating rGO nanosheets. Although, all these surface molecules increase the stability of rGO in aqueous media they are not optimized for targeted delivery to tumor cells.…”

Section: ■ Introductionmentioning

confidence: 99%

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Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption

Hashemi

Omidi

Muralidharan

et al. 2017

ACS Appl. Mater. Interfaces

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Strong near-infrared (NIR) absorption of reduced graphene oxide (rGO) make this material a candidate for photothermal therapy. The use of rGO has been limited by low stability in aqueous media due to the lack of surface hydrophilic groups. We report synthesis of a novel form of reduced graphene-arginine (rGO-Arg) as a nanoprobe. Introduction of Arg to the surface of rGO not only increases the stability in aqueous solutions but also increases cancer cell uptake. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) images are recorded to characterize the morphology of rGO-Arg. Fourier transform infrared (FTIR), X-ray photoelectron spectra (XPS), Raman, and UV-vis spectroscopy are utilized to analyze the physiochemical properties of rGO-Arg. Interaction of rGO-Arg with 808 nm laser light has been evaluated by measuring the absorption cross section in response to periodically modulated intensity to minimize artifacts arising from lateral thermal diffusion with a material scattering matched to a low scattering optical standard. Cell toxicity and cellular uptake by MD-MB-231 cell lines provide supporting data for the potential application of rGO-Arg for photothermal therapy. Absorption cross-section results suggest rGO-Arg is an excellent NIR absorber that is 3.2 times stronger in comparison to GO.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption

Hashemi

Omidi

Muralidharan

et al. 2017

ACS Appl. Mater. Interfaces

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“…Imani et al also found changes in size of the rGOs when surface polymers were added, in addition, a small drop in zeta potential was also observed when PEG was added. 33 …”

Section: Resultsmentioning

confidence: 99%

“…Imani et al also found changes in size of the rGOs when surface polymers were added, in addition, a small drop in zeta potential was also observed when PEG was added. 33 The PEGFA was obtained by 3 synthetic routes. The products of all steps were characterized by 1H NMR and FTIR and the precursor PEG for comparison.…”

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confidence: 99%

Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration

Romero¹,

Buzzá²,

Stringasci³

et al. 2021

IJN

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Introduction: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy. Methods: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2). Results: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT. Discussion: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments.

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“…Octylbenzene is a type of alkylbenzene; however, in their research, other molecules were not investigated. It has been under the argument that the alkyl chain [23][24][25][26][27] or aromatic moiety [28][29][30][31][32][33][34][35][36] contributes to the graphene dispersion. To make clear the role of the alkyl chain and the aromatic moiety of the dispersant, we synthesized a series of alkylbenzenes and evaluated their graphene dispersing abilities.…”

Section: Introductionmentioning

confidence: 99%

Structural Optimization of Alkylbenzenes as Graphene Dispersants

Takeda

Nishina

2020

Processes

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Among the several methods of producing graphene, the liquid-phase exfoliation of graphite is attractive because of a simple and easy procedure, being expected for mass production. The dispersibility of graphene can be improved by adding a dispersant molecule that interacts with graphene, but the appropriate molecular design has not been proposed. In this study, we focused on aromatic compounds with alkyl chains as dispersing agents. We synthesized a series of alkyl aromatic compounds and evaluated their performance as a dispersant for graphene. The results suggest that the alkyl chain length and solubility in the solvent play a vital role in graphene dispersion.

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Improved dispersibility of nano-graphene oxide by amphiphilic polymer coatings for biomedical applications

Abstract: The poor dispersibility of graphene-based nano-materials in aqueous media is a crucial limitation in their biological applications.

Cited by 20 publications

References 32 publications

Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption

Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption

Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration

Structural Optimization of Alkylbenzenes as Graphene Dispersants

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