Improved diagnosis of the number of stenosed coronary artery vessels by segmentation with scatter and photo-peak window data for attenuation correction in myocardial perfusion SPECT

Yamauchi, Yohei; Kanzaki, Yumiko; Hayashi, Meiso; Arai, Mami; Morita, Hideaki; Komori, Tsuyoshi; Hoshiga, Masaaki; Ishizaka, Nobukazu

doi:10.1007/s12350-017-1058-x

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Five studies used 201 Tl ( 13 , 14 , 28 – 30 ), 15 studies used 99m Tc, and two studies used dual radiotracers ( 19 , 27 ). Twelve studies used CTAC, seven studies used RAC ( 19 , 27 , 29 , 31 – 34 ), two studies used AC with segmentation of scatter and photo-peak window data (SSPAC) ( 35 , 36 ), and one study used computer-generated Chang AC ( 30 ). The detailed characteristics of each study are shown in Table 1 ( 13 – 16 , 19 , 20 , 26 – 41 ).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Huang

Yen

et al. 2021

Front. Cardiovasc. Med.

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Background: The aim of this study was to determine whether, and if so how, attenuation correction (AC) improves the diagnostic performance of myocardial perfusion imaging (MPI) in different coronary artery-supplied territories, using coronary angiography as the reference standard.Methods: PubMed and EMBASE were searched until December 2020 for studies evaluating AC MPI for the diagnosis of coronary artery disease (CAD) with vessel-based data. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. For each study, the sensitivity, specificity, diagnostic odds ratios and areas under summary receiver operating characteristic curves (AUC) with 95% confidence intervals were calculated to determine the diagnostic accuracy of AC compared to non-AC MPI. A bivariate mixed-effects model was used to pool the data. Subgroup analyses considering the type of radiotracer and type of AC were performed.Results: A total of 264 articles were screened, of which 22 studies (2,608 patients) were enrolled. Significant improvements in specificity [0.78 vs. 0.58 in overall CAD, 0.87 vs. 0.61 in right coronary artery (RCA)] and diagnostic odds ratios (16 vs. 8 in overall CAD, 18 vs. 7 in RCA) after AC were shown in overall CAD at a patient level and RCA stenosis. Improvements in AUC were also noted. MPI had a similar diagnostic performance for detecting left anterior descending and left circumflex coronary artery stenosis with or without AC. There were trends of decreased sensitivity after AC, but none were significant. Diagnostic odds ratio showed significant improvement after AC only in the technetium-99m subgroup.Conclusion: The results of this study suggest that AC should be applied to MPI to improve the diagnosis of CAD regardless of which type of radiotracer, and that AC MPI can improve the specificity of detecting RCA stenosis.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Huang

Yen

et al. 2021

Front. Cardiovasc. Med.

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“…A summary of 16 studies (n=2,092 patients) revealed that the diagnostic sensitivity and specificity of semiconductor SPECT were 84% [95% confidence interval (CI), 78%-89%] and 69% (95% CI, 62%-76%) respectively (4). A comparison of scatter segmentation and photo-peak window data (SSPAC) and non-correction methods for diagnosing individual coronary territories showed that the vessel-based diagnostic ability, sensitivity, specificity, and positive and negative predictive values of the 3-detector SPECT with and without attenuation correction using SSPAC were 77%, 89%, 74%, and 90%, and 51%, 87%, 62%, and 82%, respectively (17). Although diagnostic ability depends on patient selection criteria, the present findings between the modalities were comparable, which supported our conclusions.…”

Section: Accuracy Of Myocardial Perfusion Spect To Detect Coronary Artery Diseasementioning

confidence: 99%

Comparison of Myocardial Ischemia Detection Between Semiconductor and Conventional Anger-type Three-detector SPECT

Yoneyama

Nakajima

Taki³

et al. 2021

Annals of Nuclear Cardiology

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Objective: Although semiconductor single-photon emission computed tomography (D-SPECT) has been used for myocardial perfusion imaging, few studies have compared its ability to detect myocardial ischemia with that of 3detector SPECT (GCA9300R). This study used invasive coronary angiography to determine whether the detectability of myocardial ischemia differs between D-SPECT and GCA9300R. Materials and methods: This study included 24 patients who were assessed by coronary angiography within 60 days of myocardial perfusion D-SPECT and GCA9300R. Two nuclear medicine physicians interpreted myocardial perfusion D-SPECT and GCA9300R images with five grades of confidence, then defined regions of ischemia on polar maps. The gold standard was determined by another nuclear cardiology specialist based on integrated assessment of the coronary angiography findings and other clinical information derived from medical charts. The concordance rate and the Cohen kappa (κ) between D-SPECT and GCA9300R were calculated. Results: The sensitivity, specificity, negative and positive predictive values, and the accuracy of patient-based diagnoses were 66.7%, 91.7%, 89.2%, 72.8%, and 85.5%, respectively, for GCA9300R, and 83.3%, 83.3%, 93.7%, 62. 4%, and 83. 3%, respectively, for D-SPECT. Interpretations of ischemia did not uncover any significant differences between D-SPECT and GCA9300R. The Cohen κ values of D-SPECT and GCA9300 agreed substantially, moderately and marginally for the left circumflex coronary artery (LCX) (0.68), right coronary artery (RCA) (0.43), and left anterior descending coronary artery (LAD) (0.39), respectively. Conclusions: The detectability of myocardial ischemia is comparable between D-SPECT and GCA9300R. Sensitivity is better for D-SPECT than GCA9300R. However, false-positive D-SPECT findings, especially in the apex and inferior wall should be interpreted with caution.

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“…Although each of the proposed methods has been successful to somewhat, the attenuation problem is still not fully solved, and therefore, the use of quantitative methods is difficult in SPECT due to attenuation. [6][7][13][14][15][16] In this article, it has been tried to introduce a simple, accurate, and rapid method without imposing more absorption dose to the patient. In this study, it has been tried to use the images of multienergy emitter radioisotope to find an attenuation map.…”

Section: Introductionmentioning

confidence: 99%

Attenuation correction in single-photon emission computed tomography for NURBS-based cardiac-torso phantom using dual-energy acquisition

et al. 2020

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Single photon emission tomography is widely used to detect photons emitted from the patient. Some of these emitted photons suffer from scattering and absorption because of the attenuation occurred through their path in patient's body. Therefore, the attenuation is the most important problem in single-photon emission computed tomography (SPECT) imaging. Some of the radioisotopes emit gamma rays in different energy levels, and consequently, they have different counts and attenuation coefficients. Calculation of the parameters used in the attenuation equation Nout=αNin= e− μ l Ninby mathematical methods is useful for the attenuation correction. Nurbs-based cardiac-torso (NCAT) phantom with an adequate attenuation coefficient and activity distribution is used in this study. Simulations were done using SimSET in 20—70 and 20—167 keV. A total of 128 projections were acquired over 360°. The corrected and reference images were compared using a universal image quality index (UIQI). The simulation repeated using NCAT phantom by SimSET. In the first group, no attenuation correction was used, but the Zubal coefficients were used for attenuation correction in the second image group. After the image reconstruction, a comparison between image groups was done using optimized UIQI to determine the quality of used reconstruction methods. Similarities of images were investigated by considering the average sinogram for every block size. The results showed that the proposed method improved the image quality. This study showed that simulation studies are useful tools in the investigation of nuclear medicine researches. We produced a nonattenuated model using Monte Carlo simulation method and compared it with an attenuated model. The proposed reconstruction method improved image resolution and contrast. Regional and general similarities of images could be determined, respectively, from acquired UIQI of small and large block sizes. Resulted curves from both small and large block sizes showed a good similarity between reconstructed and ideal images.

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Improved diagnosis of the number of stenosed coronary artery vessels by segmentation with scatter and photo-peak window data for attenuation correction in myocardial perfusion SPECT

Abstract: SSPAC-corrected SPECT myocardial perfusion images exhibit improved accuracy in the detection of the number of stenosed coronary artery vessels, even in patients with multi-vessel CAD.

Cited by 4 publications

References 34 publications

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Comparison of Myocardial Ischemia Detection Between Semiconductor and Conventional Anger-type Three-detector SPECT

Attenuation correction in single-photon emission computed tomography for NURBS-based cardiac-torso phantom using dual-energy acquisition

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