Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)

Abstract

Animal models are known not to predict human responses well, in general. However, we have been able to demonstrate that, for a series of non-steroidal anti-inflammatory drugs that are or were in clinical use, the incorporation of two simple physicochemical properties results in excellent correlations between human and rodent potencies for anti-inflammatory, analgesic and anti-pyretic activities. This has the potential to allow the use of historical data to improve drug development.

A QSAR Study for Analgesic and Anti‐inflammatory Activities of 5‐/6‐Acyl‐3‐alkyl‐2‐Benzoxazolinone Derivatives

“…Long term administration of NSAIDs frequently causes gastric side effects because of nonselective inhibition of cyclooxygenases (COXs) . Anti‐inflammatory activity of NSAIDs was reported to accompany analgesic potency of the same drugs . Both complex characteristic of these activities and variable benefit/risk profile of existing NSAIDs create a valid approach and need for development of more potent and safer novel drug candidates.…”