Improved Core Viscosity Achieved by PDLLA10kCo-Incorporation Promoted Drug Loading and Stability of mPEG2k-b-PDLLA2.4k Micelles

Chen, Guo; Zhang, Ying; Yuan, Haoyang; Yin, Tian; He, Haibing; Gou, Jingxin; Tang, Xing

doi:10.1007/s11095-022-03174-5

Cited by 4 publications

(2 citation statements)

References 55 publications

(67 reference statements)

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“…Similar trends were also noted for the PEG 10 PCL y series (SI, Figure S10), indicating that even prior to lyophilization/reconstitution, the addition of β-CD promoted significant aggregation and morphological changes in the micelles when the PEG M n was >2 kDa. This behavior may be related to the formation of pseudo-rotaxanes between the β-CD and the PEG corona of the micelles, with subsequent hydrogen-bonding between the β-CD leading to aggregation of the micelles [46][47][48][49]. β-CD is also known to form inclusion complexes with PCL, which may also contribute to the disruption of the micelle morphology [50][51][52][53].…”

Section: Effects Of Lyophilization and Reconstitution On Blank Micellesmentioning

confidence: 99%

Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles

et al. 2023

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Polymeric micelles are promising carriers for the delivery of poorly water-soluble drugs, providing enhanced drug solubility, blood circulation times, and bioavailability. Nevertheless, the storage and long-term stability of micelles in solution present challenges requiring the lyophilization and storage of formulations in the solid state, with reconstitution immediately prior to application. Therefore, it is important to understand the effects of lyophilization/reconstitution on micelles, particularly their drug-loaded counterparts. Herein, we investigated the use of β-cyclodextrin (β-CD) as a cryoprotectant for the lyophilization/reconstitution of a library of poly(ethylene glycol-b-ε-caprolactone) (PEG-b-PCL) copolymer micelles and their drug-loaded counterparts, as well as the effect of the physiochemical properties of different drugs (phloretin and gossypol). The critical aggregation concentration (CAC) of the copolymers decreased with increasing weight fraction of the PCL block (fPCL), plateauing at ~1 mg/L when the fPCL was >0.45. The blank (empty) and drug-loaded micelles were lyophilized/reconstituted in the absence and presence of β-CD (9% w/w) and analyzed via dynamic light scattering (DLS) and synchrotron small-angle X-ray scattering (SAXS) to assess for changes in aggregate size (hydrodynamic diameter, Dh) and morphology, respectively. Regardless of the PEG-b-PCL copolymer or the use of β-CD, the blank micelles displayed poor redispersibility (<10% relative to the initial concentration), while the fraction that redispersed displayed similar Dh to the as-prepared micelles, increasing in Dh as the fPCL of the PEG-b-PCL copolymer increased. While most blank micelles displayed discrete morphologies, the addition of β-CD or lyophilization/reconstitution generally resulted in the formation of poorly defined aggregates. Similar results were also obtained for drug-loaded micelles, with the exception of several that retained their primary morphology following lyophilization/reconstitution, although no obvious trends were noted between the microstructure of the copolymers or the physicochemical properties of the drugs and their successful redispersion.

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Section: Effects Of Lyophilization and Reconstitution On Blank Micellesmentioning

confidence: 99%

Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles

et al. 2023

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“…ter, with normal micelles being the carriers of choice, while hydrophilic drugs can be delivered using reversed micelles. 99 This makes them ideal for targeting ocular tissue and increasing corneal permeability when applied topically. Micelles, despite their challenges in drug loading, scalability, and potential toxicity from surfactant use, offer notable benefits for DED treatment.…”

Section: Micellesmentioning

confidence: 99%

Nanotechnology-based Therapeutic Strategies for Dry Eye Disease

Philip¹

2023

J Explor Res Pharmacol

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Dry eye disease (DED) is a prevalent ocular condition affecting a significant proportion of the global population. Characterized by disruption of tear film homeostasis, DED results in dryness, discomfort, impaired visual clarity, and potential corneal damage. Despite its severe consequences, consistently effective treatments for DED remain elusive, leaving the majority of patients with persistent symptoms. This review aims to examine recent advancements in DED therapy, emphasizing the role of nanotechnology-based delivery systems in the development of novel treatments. By harnessing the potential of cutting-edge nanotechnology, we aspire to unveil innovative therapeutic strategies that address the unmet needs of patients with DED. Furthermore, we will discuss the current challenges, limitations, and future associated with these novel nanotechnology-based therapies for managing DED.

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