Improved column-based radiochemical processing of the generator produced 68Ga

68Ga-DOTA and analogs: Current status and future perspectives

“…Typically, 68 Ga 3+ is trapped on the strong cation exchange cartridge (SCX), then converted with HCl, HCl/acetone or NaCl into [ 68 GaCl 4 ] − and transferred with a small volume of concentrated HCl to the strong anion exchange cartridge (SAX) and finally eluted with water or slightly acidic solution. [12][13][14][15] The process could be easily automated for the reproducible preparation of ready-to-use 68 Ga 3+ in optimal activity and chemical form for labeling. 16 The generators based on zirconium nanoparticles and organic matrix could be eluted under milder conditions and gallium-68 ions are easier to form suitable complexes for clinical use.…”

Peptide synthesis, characterization and 68Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT

“…Interestingly, the authors also tested cationic exchange purification (SCX) method, with no particular difference compared to the SAX based method. The fractionated elution method yielded a very high 68 Ga-activity, but it has been reported that SCX/SAX postprocessing is more efficient than fractionated elution of the generator [44][45][46][47][48], mainly reducing co-eluted metal impurities and 68 Ge-breakthrough levels. We focused on the impact that a simple post-processing procedure has on the crude %LE of the NOTA-peptide conjugates.…”

Gallium-68: Radiolabeling of Radiopharmaceuticals for PET Imaging - A Lot to Consider

“…These post-elution purification methods, so called post-processing's, aim to improve the radioactive and [H + ] concentration and the radionuclidic as well as chemical purity of the 68 Ga-eluate. Beside fractionation of the eluate [11], anion-exchange (AEX) [13], cation-exchange (CEX) [27][28][29] and a combination thereof [30,31] found to be suitable but only for fractionation but also are commercially used for cation-exchange.…”