Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA

Wang, Shuo; Liu, Zengyi; Yue, Tong; Zhai, Yunqian; Zhao, Xiujie; Yue, Xinmin; Qiao, Yanqi; Liu, Yonghui; Yin, Yongmei; Xi, Rimo; Zhao, Wei; Meng, Meng

doi:10.1016/j.jconrel.2020.12.048

Cited by 36 publications

(21 citation statements)

References 43 publications

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“…The thermal image of the temperature change of each sample was recorded every 1.0 min via an infrared imager (HIKVISION, H10, China) during 5 min. Meanwhile, the temperature changes of IHTM NPs solutions with different concentrations (5,10,25, and 50 μg/mL) under laser irradiation were consistent with the methods mentioned above.…”

Section: Stability Of Ihtmsupporting

confidence: 80%

“…In addition to surgery and radiation therapy, chemotherapy remains one of the most widely used clinical treatments for localized and metastatic tumors, and it has successfully extended patient survival. , Most conventional chemotherapeutic drugs are effective in killing tumor cells, but poor tumor selectivity and rapid clearance can lead to suboptimal treatment outcomes, like systemic toxic side effects and drug resistance . In the past decades, two noninvasive light therapy modalities, photodynamic therapy (PDT) and photothermal therapy (PTT), have been proven to be promising therapeutic techniques. − Both PDT and PTT are superior to chemotherapy in terms of target selectivity, strong controllability, and fewer systemic effects. , IR780 is a stable near-infrared heptamethine cyanine dye, which has attracted much attention due to its excellent photothermal conversion efficiency and excellent performance in near-infrared fluorescence imaging. − …”

Section: Introductionmentioning

confidence: 99%

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Design of ROS-Responsive Hyaluronic Acid–Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer

et al. 2022

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Combining chemotherapy with photothermal therapy (PTT) for cancer treatment could overcome the inherent limitations of both single-modality chemotherapy and PTT. However, the obstacle of accurate drug delivery to tumor sites based on chemo-photothermal remains challenging. This article describes development of a reactive oxygen species (ROS)-responsive hyaluronic acid-based nanoparticle to overcome these drawbacks. Herein, HA-TK-MTX (HTM) was synthesized by a ROS-responsive cleaved thioketal moiety linker (TK) of methotrexate (MTX) and hyaluronic acid (HA). Through hydrophobic interaction and π–π stacking interaction, a photothermal agent IR780 was integrated into the HTM, and the IR780/HTM nanoparticles (IHTM NPs) were obtained. The IHTM NPs show high photostability, excellent photothermal performance, remarkable tumor-targeting ability, and ROS sensibility. Due to the accurate drug delivery ability and superior chemo-photothermal treatment effect of IHTM NPs, the tumor inhibition rate reached 70.95% for 4T1 tumor-bearing mice. This work serves as a precedent for the chemo-photothermal therapy of cancer by rationally designing ROS-responsive nanoparticles.

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Section: Stability Of Ihtmsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Design of ROS-Responsive Hyaluronic Acid–Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer

et al. 2022

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“…These problems have been partially solved by loading IR‐780 to a tetrahedral DNA nanoarchitecture. [ 203 ] On the other hand, red fluorescent protein KillerRed was bound to double‐bundle DNA tetrahedron, and used for PDT. [ 204 ] Conjugations of aptamers to various photosensitizers were attempted to target specific cells.…”

Section: Smart Dds Using Physical Stimuli Provided From the Outside O...mentioning

confidence: 99%

DNA‐Based Nanoarchitectures as Eminent Vehicles for Smart Drug Delivery Systems

Komiyama

Shigi

Ariga

2022

Adv Funct Materials

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In order to cure diseases efficiently with minimal side effects in sophisticated medicine, eminent drugs must be selectively delivered to diseased parts and allow to work only there. However, most of drug delivery systems (DDSs) previously proposed are not yet sufficiently selective and effective. This review covers recent developments of DDS in which DNA nanoarchitectures are employed as drug carriers. From short DNA fragments, a variety of complicated nanomedicines are fabricated to show unprecedentedly smart DDS functions. Encapsulated drugs are released mostly through controlled disassembly of DNA nanoarchitectures. Recent attention has been focusing to the use of appropriate stimuli to regulate each process in the DDS (delivery of drug, its release, and others) for further improved therapy. As intracellular stimuli for the regulation, various endogenous compounds (e.g., mRNA and enzymes), which are specifically abundant in target cells, are employed. Alternatively, physical perturbation (e.g., light irradiation) is provided from outside of tissues to control DDS. By combining multiple strategies in terms of new concepts, enormously smart DDSs are being achieved. Further progresses of these approaches in the future are guaranteed by complete freedom of molecular design in DNA nanoarchitectonics.

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“…Compared with clinic‐approved indocyanine green (ICG), IR780 shows a higher fluorescence intensity and stability. [ 6 ] And accumulating evidence suggests that the combination of IR780‐mediated PTT or PDT with other treatments display a higher T lymphocytes activation and tumor immunosuppressive microenvironment remodeling. [ 7 ] However, the underlying mechanism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Dual Tumor Microenvironment Remodeling by Glucose‐Contained Radical Copolymer for MRI‐Guided Photoimmunotherapy

Cheng

Fan

et al. 2021

Advanced Materials

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Aberrant glucose metabolism and immune evasion are recognized as two hallmarks of cancer, which contribute to poor treatment efficiency and tumor progression. Herein, a novel material system consisting of a glucose and TEMPO (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl) at the distal ends of PEO‐b‐PLLA block copolymer (glucose‐PEO‐b‐PLLA‐TEMPO), is designed to encapsulate clinical therapeutics CUDC101 and photosensitizer IR780. The specific core–shell rod structure formed by the designed copolymer renders TEMPO radicals excellent stability against reduction‐induced magnetic resonance imaging (MRI) silence. Tumor‐targeting moiety endowed by glucose provides the radical copolymer outstanding multimodal imaging capabilities, including MRI, photoacoustic imaging, and fluorescence imaging. Efficient delivery of CUDC101 and IR780 is achieved to synergize the antitumor immune activation through IR780‐mediated photodynamic therapy (PDT) and CUDC101‐triggered CD47 inhibition, showing M1 phenotype polarization of tumor‐associated macrophages (TAMs). More intriguingly, this study demonstrates PDT‐stimulated p53 can also re‐educate TAMs, providing a combined strategy of using dual tumor microenvironment remodeling to achieve the synergistic effect in the transition from cold immunosuppressive to hot immunoresponsive tumor microenvironment.

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Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA

Cited by 36 publications

References 43 publications

Design of ROS-Responsive Hyaluronic Acid–Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer

Design of ROS-Responsive Hyaluronic Acid–Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer

DNA‐Based Nanoarchitectures as Eminent Vehicles for Smart Drug Delivery Systems

Dual Tumor Microenvironment Remodeling by Glucose‐Contained Radical Copolymer for MRI‐Guided Photoimmunotherapy

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