Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating

Huang, Zhi‐Zhen; Scicolone, James V.; Han, Xiaomin; Davé, Rajesh N.

doi:10.1016/j.ijpharm.2014.11.068

Cited by 85 publications

(25 citation statements)

References 48 publications

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“…The host material (mAPAP) and a small amount of guest material (R972P) were put into a plastic jar, and processed for 5 min at intensity equivalent to 75 times gravitational acceleration. These process parameters are based on previous work (Capece et al, 2014;Huang et al, 2015b;Mullarney et al, 2011). The shearing forces generated in LabRAM resulted in collisions between particle and particle, as well as particle and wall, helping break the API agglomerates and coat the guest particles onto the surface of host particles due to strong inter-particle forces.…”

Section: Dry Particle Coatingmentioning

confidence: 99%

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Improving blend content uniformity via dry particle coating of micronized drug powders

Huang

Xiong

Kunnath

et al. 2017

European Journal of Pharmaceutical Sciences

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Content uniformity of low dose blends with fine active pharmaceutical ingredients (API) is adversely impacted due to API agglomeration caused by high powder cohesion. Dry coating using high-intensity vibratory mixing is employed to reduce API cohesion and granular Bond number as well as agglomeration as predicted by contact models, hence improve blend content uniformity (CU). Micronized acetaminophen (mAPAP) (~10μm), a model API, was dry coated with nano-silica R972P (20nm), and mixed with Avicel 102. The amount of silica was varied from 0 to 2.74wt%, corresponding to theoretical surface area coverage (SAC) from 0 to 100% respectively. Bulk density, unconfined yield strength, and dispersive surface energy results indicated dry coating with 0.27 to 1.0wt% silica was adequate for API property enhancement; further corroborated by improved CU for 5wt% API blends. Excellent CU was achieved for 3, 5 and 10wt% API loaded blends, where 30min of mixing was found to be acceptable for all three. The CU with dry coated mAPAP was significantly lower and within the acceptable range as compared to control blends without silica, as well as those with silica added during blending. Sieving of mAPAP illustrated the reduction in mAPAP agglomeration, necessary for improved CU after dry coating, corroborating model based predictions. Compared to theoretical predictions, actual CU was higher unless API agglomerate size distribution obtained via sieving was taken into account. Overall, cohesion reduction by dry coating is shown as a promising approach for improving content uniformity of cohesive API blends.

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Section: Dry Particle Coatingmentioning

confidence: 99%

“…The detailed description of test procedures can be found in (Freeman, 2007;Han et al, 2011;Huang et al, 2015b). Bulk density and unconfined yield strength (the compressed powder bed strength) were attained from bulk density and shear tests at 3kPa, respectively.…”

Section: Powder Testermentioning

confidence: 99%

Improving blend content uniformity via dry particle coating of micronized drug powders

Huang

Xiong

Kunnath

et al. 2017

European Journal of Pharmaceutical Sciences

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“…The Biopharmaceutical Classification System (BCS) divides drugs into four classes according to their solubility and permeability (Sharma et al, 2009). Valsartan, an Angiotensin II Receptor Antagonist, which is used in the prevention and treatment of Hypertension (Abraham et al, 2011) belongs to class II drug in BCS classification indicates high permeability and low solubility (Moore and Wildfong, 2009;Jinno et al, 2006). The foremost problem with this drug is its low solubility in biological fluids, resulting in poor bioavailability after oral administration.…”

Section: Introductionmentioning

confidence: 99%

Self microemulsifying powder using Aerosil as a carrier

Arju

Bara

Amin

et al. 2021

Bangladesh J. Sci. Ind. Res.

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This investigation highlighted the development of a solid self micro emulsifying drug delivery system (solid SMEDDS) for improved oral delivery of Valsartan. Liquid SMEDDS were formulated and then the liquid formulation was transformed into free-flowing powder by adsorption on a solid carrier. Here the formulations were prepared in various ratios of the drug to the excipients. Various evaluation studies were performed. In-vitro release profiles of all formulations were evaluated. The concentration of the diffused drug was measured using a UV-visible spectrophotometer at λmax= 250 nm. The faster dissolution was exhibited by the formulations containing Avicel. The experimental results for prepared solid-SMEDDS showed the improved dissolution of the study drug in a short time. F-3 (Assay:77%; Dissolution: 51.7% after 45 min, 63% after 60 min) and F-4 (Assay:63%; Dissolution: 49.1% after 45 min, 67% after 60 min) showed better evaluation study and this two might be formulated in future. Thus, this study revealed the formulation solid-SMEDDS using Aerosil 200 as an adsorbent with the potential of enhancing the solubility, and dissolution rate of the drug. Bangladesh J. Sci. Ind. Res.56(2), 141-146, 2021

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“…For example, Hybridizer, Mechanofusion and Mechanomill processes are some advances of grinding machines or Cyclomix Ò [9 11], are used for dry particle coating. New mixers are used for coating, such as the resonant acoustic mixer (RAM) in which an acoustic field spreads to provide the necessary energy for coating [12]. During the past five years, several researchers have realized processes that can simultaneously achieve multiple func tions, such as milling and coating.…”

Section: Introductionmentioning

confidence: 99%

Production of composite particles using an innovative continuous dry coating process derived from extrusion

Cavaillès

Sescousse

Chamayou

et al. 2017

Advanced Powder Technology

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Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating

Cited by 85 publications

References 48 publications

Improving blend content uniformity via dry particle coating of micronized drug powders

Improving blend content uniformity via dry particle coating of micronized drug powders

Self microemulsifying powder using Aerosil as a carrier

Production of composite particles using an innovative continuous dry coating process derived from extrusion

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