Improved Bioresorbable Microporous Intravascular Stents for Gene Therapy

Ye, Yun Wei; Landau, Charles; Meidell, Robert S.; Willard, John E.; Moskowitz, Ari; Aziz, Sheza; Carlisle, Eric; Nelson, Kevin D.; Eberhart, Robert C.

doi:10.1097/00002480-199609000-00105

Cited by 18 publications

(5 citation statements)

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“…PHB and their copolymers are extensively used in the biomedical devices such as bone plates, sutures, rivets staple screws, orthopedic pins and bone marrow scaffolds. The uniqueness of these polymers is that it can be either Knitted-type balloon expanded PGA dog coronary artery [73] Knitted-type balloon expanded PGA pig coronary artery [74][75] Diamond braided self-expanded PLLA dog femoral [76] Film -PCL/(D, L)PLA porcine carotid [77] Tubular coil balloon PLLA-PCL rabbit carotid arteries [78] Coil stent self-expanded PLLA human coronary [75] Drug eluting thermal expanded PLLA pig coronary [76] blended or co-polymerized, and tailor made to achieve the desired properties. The crystallinity and mechanical properties of P (HB-HV) can be adjusted by varying the ratio of the respective monomers.…”

Section: Poly (3-hydroxybutyrate) (Phb) and Co-polymersmentioning

confidence: 99%

A review on biodegradable materials for cardiovascular stent application

Hou

Pan

et al. 2016

Front. Mater. Sci.

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A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researchers and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials.

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Section: Poly (3-hydroxybutyrate) (Phb) and Co-polymersmentioning

confidence: 99%

A review on biodegradable materials for cardiovascular stent application

Hou

Pan

et al. 2016

Front. Mater. Sci.

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“…Another proposed design is a combines polymeric with a metallic backbone to increase strength and prevent recoil. In 1996, Ye et al [25] used a PLLA/PCL blend stent impregnated with a recombinant adenovirus carrying the β-Gal reporter gene and demonstrated a successful transfer and expression of this gene in cells of the arterial wall in rabbits. In 1997, PLLA was associated with an intense inflammatory reaction, whereas a minimal inflammatory reaction was observed with molecular mass >300 kDa [26].…”

Section: History Of Polymeric Biodegradable Stent Developmentmentioning

confidence: 99%

Polymeric Biodegradable Stent Insertion in the Esophagus

et al. 2016

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Esophageal stent insertion has been used as a well-accepted and effective alternative to manage and improve the quality of life for patients diagnosed with esophageal diseases and disorders. Current stents are either permanent or temporary and are fabricated from either metal or plastic. The partially covered self-expanding metal stent (SEMS) has a firm anchoring effect and prevent stent migration, however, the hyperplastic tissue reaction cause stent restenosis and make it difficult to remove. A fully covered SEMS and self-expanding plastic stent (SEPS) reduced reactive hyperplasia but has a high migration rate. The main advantage that polymeric biodegradable stents (BDSs) have over metal or plastic stents is that removal is not require and reduce the need for repeated stent insertion. But the slightly lower radial force of BDS may be its main shortcoming and a post-implant problem. Thus, strengthening support of BDS is a content of the research in the future. BDSs are often temporarily effective in esophageal stricture to relieve dysphagia. In the future, it can be expect that biodegradable drug-eluting stents (DES) will be available to treat benign esophageal stricture, perforations or leaks with additional use as palliative modalities for treating malignant esophageal stricture, as the bridge to surgery or to maintain luminal patency during neoadjuvant chemoradiation.

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“…73 Successful gene transfer and expression have been demonstrated after implantation of polymeric stents impregnated with an adenoviral vector encoding ␤-galactosidase in rabbit carotid arteries. 74 …”

Section: Delivery Of Vectors To the Vasculaturementioning

confidence: 99%