Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process

Cheng, Ce; Li, Ziling; Zou, Liqiang; Liu, Wei; Liu, Chengmei

doi:10.1039/c7ra02861j

Cited by 161 publications

(125 citation statements)

References 44 publications

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“…By this method, CUR was deprotonated and dissolved under alkaline conditions before than been encapsulated into the liposomes after acidification. The CUR loaded liposomes prepared by the pH-driven combine the advantages showed by the liposomes prepared by the thin film and by the ethanol injection methods: (1) They are stable under storage and (2) They showed high bioaccessibility [77].…”

Section: Liposomesmentioning

confidence: 99%

Encapsulation for Cancer Therapy

et al. 2020

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The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations—offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.

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Section: Liposomesmentioning

confidence: 99%

Encapsulation for Cancer Therapy

et al. 2020

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“…Later on, lactoferrin encapsulated in liposomes prepared from phospholipid milk showed good stability, and liposomes showed that can prevent lactoferrin degradation and reduce the rate of hydrolysis under intestinal conditions (Liu et al, 2013). In another study, curcumin-loaded liposomes prepared by different methodologies were evaluated during in vitro digestion, and curcumin liposomes prepared by the pH-driven method showed similar bioaccessibility to those prepared by the thin film method and higher bioaccessibility than those prepared by the ethanol injection method (Cheng et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Liposomes loaded with phenolic extracts of Spirulina LEB-18: Physicochemical characterization and behavior under simulated gastrointestinal conditions

Machado

Pinheiro²,

Vicente

et al. 2019

Food Research International

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Liposomes composed of rice (RL) and soybean (SL) lecithins were produced by reverse phase evaporation and used for the encapsulation of phenolic extracts from Spirulina LEB-18 (S-RL and S-SL for liposomes of rice and soybean lechitin, respectively). Liposomes were characterized in terms of size distribution, polydispersity index, and ζ-potential; the chemical interactions between the phenolic compounds from Spirulina and liposomes were evaluated by Fourier Transform Infrared Spectroscopy (FTIR), and X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to evaluate their crystallinity pattern. The release behavior of phenolic extracts was evaluated under two different pH conditions. Afterwards, in vitro digestibility of liposomes was evaluated in a dynamic gastrointestinal system. Liposomes exhibited high encapsulation efficiency (88.28% and 97.35% for S-RL and S-SL, respectively) and sizes ranging between 250 and 291 nm, showing to be good candidates for the encapsulation of phenolic extracts obtained from microalgae. Results showed that liposomes are stable at low pH values and that they are able to resist to the stomach conditions but they lose their integrity under intestinal conditions. This work increases the knowledge about the effects of in vitro gastrointestinal digestion on liposomes and provides important information for the design of liposome formulations aiming their application in pharmaceutical and food applications.

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“…Despite curcumin's therapeutic benefits, translation of doses for clinical application is unfeasible due to its poor bioavailability contributed by poor solubility (<1 mg/ml), slow dissolution rate, extensive intestinal and hepatic metabolic transformation along with its rapid elimination [11,12]. So far, literature reports development of various drug delivery systems like liposomes [13,14], cyclodextrin complexes [15], self-emulsifying system [16,17], biodegradable polymeric nanoparticles [18,19], solid lipid nanoparticles (SLNs) [20,21], nano-emulsion [22,23] for topical and parenteral delivery of curcumin in variety of therapeutic applications. However, curcumin formulations have conferred confined success via oral route.…”

Section: Introductionmentioning

confidence: 99%

Improved uptake and therapeutic intervention of curcumin via designing binary lipid nanoparticulate formulation for oral delivery in inflammatory bowel disorder

Sharma

Wadhwa

2019

Artificial Cells, Nanomedicine, and Biotechnology

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This study was focussed on development of curcumin loaded solid binary lipid nanoparticles (C-SBLNs) to ameliorate stability, uptake and therapeutic potential of curcumin during inflammatory bowel disease (IBD). C-SBLNs with nano-size range (210.56 ± 41.22 nm) and high entrapment efficiency (83.12 ± 6.57%) were prepared by solvent emulsification evaporation method using binary lipids i.e. stearic acid and tristearin after optimizing various formulation and process variables. Physicochemical characterization of C-SBLNs by ATR-FTIR confirmed drug entrapment whereas thermal and pXRD study corroborated loss of crystallinity of drug into C-SBLNs. Lyophilized C-SBLNs were found to be spherical shaped with good gastrointestinal stability and prolonged drug release up to 24 h. Optimized C-SBLNs formulation displayed significantly enhanced cellular uptake and localization in inflamed tissues during IBD. Oral administration of C-SBLNs in DSS induced colitis model revealed significant reduction in leucocyte infiltration, oxidative stress, pro-inflammatory cytokine (TNF-a) secretion and maintenance of colonic structure similar to healthy animal group compared to curcumin. Thus, in vitro and preclinical findings of study clearly confirmed that C-SBLNs could be a stable and efficacious alternative platform for curcumin delivery with strong competence in IBD chemotherapy.

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Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process

Abstract: pH-driven method, an organic solvent-free and easily scale-upable method, was firstly utilized to prepared curcumin-loaded liposomes.

Cited by 161 publications

References 44 publications

Encapsulation for Cancer Therapy

Encapsulation for Cancer Therapy

Liposomes loaded with phenolic extracts of Spirulina LEB-18: Physicochemical characterization and behavior under simulated gastrointestinal conditions

Improved uptake and therapeutic intervention of curcumin via designing binary lipid nanoparticulate formulation for oral delivery in inflammatory bowel disorder

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