Improved Astaxanthin Synthesis in Komagataella phaffii through β-Carotene Ketolase Screening and β-Carotene Hydroxylase Mutagenesis
Nan Wang,
Wenfang Guo,
Caifeng Yang
et al.
Abstract:Astaxanthin is highly valued for its superior antioxidant properties and a variety of applications, prompting extensive research into its synthesis via microbial metabolic engineering. Commonly, organisms such as Escherichia coli, Saccharomyces cerevisiae, and Yarrowia lipolytica have been studied for astaxanthin production. Komagataella phaffii, known for its efficacy in heterologous protein expression, has been less explored for astaxanthin synthesis. This study investigates the potential of K. phaffii, leve… Show more
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