Improved anemia is associated with favorable long-term clinical outcomes in patients undergoing PCI

Kim, Tae-Hoon; Koh, Yoon Seok; Chang, Kiyuk; Seo, Suk-Min; Kim, Chan-Joon; Park, Hun‐Jun; Kim, Pum-Joon; Her, Sung Ho; Kim, Dong‐Bin; Lee, Jongmin; Park, Chul‐Soo; Kim, Hee-Yeol; Yoo, Ki‐Dong; Jeon, Doo Soo; Park, Jae Hong; Chung, Wook-Sung; Seung, Ki‐Bae

doi:10.1097/mca.0b013e3283564869

Cited by 11 publications

(4 citation statements)

References 25 publications

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“…Anaemia is common amongst patients undergoing percutaneous coronary interventions (PCI) with prevalent rates reported between 10-23% in randomised controlled trials (1-3)and rates greater than 30% reported in observational registries (4,5). Current clinical guidelines fail to offer recommendations for its concurrent management in patients undergoing PCI.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

Kwok

Tiong

Pradhan

et al. 2016

The American Journal of Cardiology

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Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse cardiovascular events (MACE), and major bleeding in patients undergoing PCI. We searched MEDLINE and EMBASE for studies that evaluated mortality and adverse outcomes in anemic and nonanemic patients who underwent PCI. Data were collected on study design, participant characteristics, definition of anemia, follow-up, and adverse outcomes. Random effects metaanalysis of risk ratios was performed using inverse variance method. A total of 44 studies were included in the review with 230,795 participants. The prevalence of baseline anemia was 26,514 of 170,914 (16%).

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Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

Kwok

Tiong

Pradhan

et al. 2016

The American Journal of Cardiology

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“…From our real-world PCI registry, the incidence of anemia was 30.5%. The incidence of anemia from other East Asian data was reported as approximately 30%–40%, 20 21 22 which was higher than that in Western countries. 6 23 Current guidelines regarding DAPT duration after PCI are mostly based on large-scale randomized trials and mainly consist of patients without high bleeding risk.…”

Section: Discussionmentioning

confidence: 75%

Long-Term Safety and Efficacy of Prolonged Dual Antiplatelet Therapy according to Baseline Anemia after Percutaneous Coronary Intervention

et al. 2022

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Purpose We aimed to evaluate the outcomes of prolonged dual antiplatelet therapy (DAPT) depending on baseline anemia after percutaneous coronary intervention (PCI). Materials and Methods Among the 1470 study participants, 448 (30.5%) were classified as having baseline anemia. We categorized the study population according to baseline anemia and DAPT duration: ≤12-month (m) DAPT (n=226) vs. >12-m DAPT (n=222) in anemic patients, and ≤12-m DAPT (n=521) vs. >12-m DAPT (n=501) in non-anemic patients. Results During a follow-up of 80.8 (interquartile range 60.6–97.1) months, anemic patients showed a higher incidence of major adverse cardiovascular and cerebrovascular events (MACCEs) (26.9% vs. 17.1%, p <0.001) and major bleeding (9.8% vs. 5.1%, p =0.006). Among the non-anemic patients, prolonged DAPT was associated with a reduced rate of MACCEs [inverse probability of treatment weighting (IPTW) adjusted hazard ratio (HR), 0.78; 95% confidence interval (CI), 0.63–0.96; p =0.019] without an increase in major bleeding (IPTW adjusted HR, 1.12; 95% CI, 0.75–1.68; p =0.574). However, prolonged DAPT was not related to the incidence of MACCEs (IPTW adjusted HR, 1.11; 95% CI, 0.88–1.39; p =0.387), with increased major bleeding (IPTW adjusted HR, 2.01; 95% CI, 1.32–3.06; p =0.001) among anemic patients. Conclusion Although extended DAPT led to a reduction in MACCEs in non-anemic patients, it was related to increased major bleeding without reducing MACCEs in anemic patients.

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“…Inflammation is very important in CAD, and low hemoglobin levels is a vital indicator of potential inflammatory processes. Similarly, patients with low hemoglobin levels and subclinical CAD may be more prone to symptomatic heart disease (59)(60)(61).…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin-to-Red-Cell Distribution Width Ratio Is a Novel Predictor of Long-Term Patient Outcomes After Percutaneous Coronary Intervention: A Retrospective Cohort Study

Xiu

Zheng

Wang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThe hemoglobin level and red cell distribution width (RDW) have been linked to the prognosis of coronary atherosclerotic heart disease (CAHD). However, the relationship between the ratio of hemoglobin to the RDW (HRR) and clinical outcomes after percutaneous coronary intervention (PCI) is not known. Here, we explored the impact of the HRR on clinical outcomes after PCI.MethodsIn our study, we selected 6,046 CAHD patients with PCI hospitalized in the First Affiliated Hospital of Xinjiang Medical University from 2008 to 2016. The patients were grouped according to their HRR ratio: group A (HRR < 10.25, n = 2,344) and group B (HRR ≥ 10.25, n = 3,702). The difference in clinical outcomes between the two groups was compared. Patients were followed up for 35.9 ± 22.6 months.ResultsThree hundred nine patients died during follow-up. These included 166 patients (7.1%) in the HRR < 10.25 group and 143 patients (3.9%) in the HRR ≥ 10.25 group (P < 0.001). The incidences of cardiogenic death (5.7 vs. 3.2%) and major cardiovascular adverse events (16.5 vs. 12.9%) also differed significantly between the groups (both Ps < 0.001). Analysis using the multivariate Cox proportional hazard model found a significant association between a decreased HRR and post-PCI mortality (all-cause death, adjusted HR: 1.479, 95% CI: 1.156–1.893, p = 0.002; cardiac death, adjusted HR: 1.470, 95% CI: 1.116–1.936, p = 0.006).ConclusionThe HRR is predictive of post-PCI mortality among CAHD patients.

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Improved anemia is associated with favorable long-term clinical outcomes in patients undergoing PCI

Abstract: The follow-up of hemoglobin level is important, and improvement of anemia is associated with favorable long-term clinical outcomes.

Cited by 11 publications

References 25 publications

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

Meta-Analysis of the Prognostic Impact of Anemia in Patients Undergoing Percutaneous Coronary Intervention

Long-Term Safety and Efficacy of Prolonged Dual Antiplatelet Therapy according to Baseline Anemia after Percutaneous Coronary Intervention

Hemoglobin-to-Red-Cell Distribution Width Ratio Is a Novel Predictor of Long-Term Patient Outcomes After Percutaneous Coronary Intervention: A Retrospective Cohort Study

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