Improved Algorithm for Automated Glucose Clamps

Kuhlenkötter, Mareike; Heise, Tim; Benesch, Carsten

doi:10.1089/dia.2016.0355

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Particle swarm algorithms are essentially a type of evolutionary algorithm. Because the algorithm has the characteristics of fast convergence speed and simple coding implementation, it has been widely used in engineering applications and other fields, and has become one of the hot directions in the field of intelligent computing research [ 20 ].…”

Section: Improved Algorithms and Related Methodsmentioning

confidence: 99%

Urban Cultural Industry Management System and Public Economic Based on Improved Algorithm

Xiong

2022

Computational Intelligence and Neuroscience

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Social reliability and sustainable financial development in metropolises have become urgent problems to be solved. Due to its solid importance and imagination, urban cultural industry management and public economy have gradually become the focus of consideration in all fields of society. Organized and coordinated improvement of the urban economy and society and imaginative undertakings have also become the focus of review at all levels of academia and government. This article aims to study and apply the improved algorithm to the urban cultural industry management system and public economic analysis. It proposed the improved algorithm and related methods, the correlation between urban cultural industry management and economy, the improved particle swarm algorithm and the SOM algorithm, and finally, applied the improved SOM algorithm to evaluate the regional economy of a city. The experimental results showed that the contribution rate of the economic evaluation level of the eight economic evaluation indicators to the economic development level of each county (district and city) in the city was different, of which, the cumulative contribution rate of the first four main components reached 83%.

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Section: Improved Algorithms and Related Methodsmentioning

confidence: 99%

Urban Cultural Industry Management System and Public Economic Based on Improved Algorithm

Xiong

2022

Computational Intelligence and Neuroscience

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“…Hence, it is important to present data on clamp quality such as control deviation (mean deviation from the target BG level) and precision (BG fluctuation from the clamp). 15 In our studies, data was derived from two automated clamps, Biostator and ClampArt and while the latter is a more modern device with some advantages, 16 clamp quality was acceptable and most importantly comparable between the treatments in all studies, even when including the low responders. Nevertheless, it is important to investigate the impact of clamps with low GIR response and BG elevations on the overall study outcome.…”

Section: Discussionmentioning

confidence: 99%

Day-to-Day and Within-Day Variability in Glucose-Lowering Effect Between Insulin Degludec and Insulin Glargine (100 U/mL and 300 U/mL): A Comparison Across Studies

Heise

Kaplan

2017

J Diabetes Sci Technol

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“…During the performance of a euglycemic clamp evaluating the PK/ PD of a long-acting insulin analog, exogenous glucose infusion was frequently and properly adjusted according to the BG to ensure good quality (Heise et al, 2016;Kuhlenkotter et al, 2017;Benesch et al, 2022). Blood insulin concentration over time (PK) always predicts insulin action; in return, the GIR over time reflects the clinical glucose-lowering effect.…”

Section: Discussionmentioning

confidence: 99%

How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers

Liu

et al. 2022

Front. Pharmacol.

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The therapeutic effect of basal insulin analogs will be sustained at a rather low insulin level. When employing healthy volunteers to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of long-acting insulin preparations by euglycemic clamp techniques, endogenous insulin cannot be ignored and sufficient endogenous insulin inhibition is crucial for the PD and/or PK assessment. This study aimed to explore a way to sufficiently inhibit endogenous insulin secretion. Healthy Chinese male and female volunteers were enrolled. After a subcutaneous injection of insulin glargine (IGlar) (LY2963016 or Lantus) (0.5 IU/kg), they underwent a manual euglycemic clamp for up to 24 h where the target blood glucose (BG) was set as 0.28 mmol/L below the individual’s baseline. Blood samples were collected for analysis of PK/PD and C-peptide. The subjects fell into two groups according to the reduction extent of postdose C-peptide from baseline. After matching for the dosage proportion of Lantus, there were 52 subjects in group A (C-peptide reduction<50%) and 26 in group B (C-peptide reduction≥50%), respectively. No significant difference was detected in age, body mass index, the proportion of Latus treatment and female participants. A lower basal BG was observed in group B compared to group A (4.35 ± 0.26 vs. 4.59 ± 0.22 mmol/L, p < 0.05). The clamp studies were all conducted with high quality (where BG was consistently maintained around the target and exhibited a low variety). The binary logistic regression analysis indicated low basal BG as an independent factor for the success of sufficient endogenous insulin suppression. In conclusion, setting a lower sub-baseline target BG (e.g., 10% instead of 5% below baseline) might be an approach to help achieve sufficient endogenous insulin suppression in euglycemic clamps with higher basal BG levels (e.g., beyond 4.60 mmol/L).

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Improved Algorithm for Automated Glucose Clamps

Abstract: With the improved algorithm, all experiments confirmed a reduction in BG- and GIR-oscillations without a major impact on other glucose clamp parameters. The optimized algorithm has been implemented in ClampArt for all future glucose clamp studies.

Cited by 7 publications

References 6 publications

Urban Cultural Industry Management System and Public Economic Based on Improved Algorithm

Urban Cultural Industry Management System and Public Economic Based on Improved Algorithm

Day-to-Day and Within-Day Variability in Glucose-Lowering Effect Between Insulin Degludec and Insulin Glargine (100 U/mL and 300 U/mL): A Comparison Across Studies

How to Achieve Sufficient Endogenous Insulin Suppression in Euglycemic Clamps Assessing the Pharmacokinetics and Pharmacodynamics of Long-Acting Insulin Preparations Employing Healthy Volunteers

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