Improved accuracy of quantitative parameter estimates in dynamic contrast-enhanced CT study with low temporal resolution

Kim, Sun Mo; Haider, Masoom A.; Jaffray, David A.; Yeung, Ivan

doi:10.1118/1.4937600

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…Tian et al presented a coupled dictionary learning methods by considering the patches in normal-dose noncontrast scans and those in low-dose enhanced scans to achieve satisfactory CTP image quality and accurate HPMs (Tian 2019). Kim et al developed principal component analysis filtering to improve the signal-to-noise of TDCs in the CTP study (Kim et al 2016). Supanich et al introduced a highly constrained back projection method to minimize the radiation dose in CTP imaging (Supanich et al 2009).…”

Section: Image Post-processing Methodsmentioning

confidence: 99%

Basis and current state of computed tomography perfusion imaging: a review

Zeng¹,

Zeng²,

Sui³

et al. 2022

Phys. Med. Biol.

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Computed tomography perfusion (CTP) is a functional imaging that allows for providing capillary-level hemodynamics information of the desired tissue in clinics. In this paper, we aim to offer insight into CTP imaging which covers the basics and current state of CTP imaging, then summarize the technical applications in the CTP imaging as well as the future technological potential. At first, we focus on the fundamentals of CTP imaging including systematically summarized CTP image acquisition and hemodynamic parameter map estimation techniques. A short assessment is presented to outline the clinical applications with CTP imaging, and then a review of radiation dose effect of the CTP imaging on the different applications is presented. We present a categorized methodology review on known and potential solvable challenges of radiation dose reduction in CTP imaging. To evaluate the quality of CTP images, we list various standardized performance metrics. Moreover, we present a review on the determination of infarct and penumbra. Finally, we reveal the popularity and future trend of CTP imaging.

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Section: Image Post-processing Methodsmentioning

confidence: 99%

Basis and current state of computed tomography perfusion imaging: a review

Zeng¹,

Zeng²,

Sui³

et al. 2022

Phys. Med. Biol.

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“…Computerized tomography (CT) technology has recently experienced significant development in terms of multi-slice 2D detector and dual-energy CT scanning capabilities. Dynamic contrast enhanced computerized tomography (DCE-CT) is hence evolving in equally new opportunities to provide, instead of testing a single anatomical slice over time, a volumetric dynamic result (Fournier et al 2010, Harders et al 2013, Ohno et al 2014, Tan et al 2015, Kim et al 2016, Qiao et al 2016. Consequently, DCE-CT can provide a dynamic test of body physiology such as blood perfusion and flow rate.…”

Section: Introductionmentioning

confidence: 99%

Development of a permeable phantom for dynamic contrast enhanced (DCE) imaging quality assurance: material characterization and testing

Lan

Naguib

Coolens

2017

Biomed. Phys. Eng. Express

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The wide-spread use of contrast-enhanced imaging is often combined with pharmaco-kinetic modeling to estimate the level of perfusion and/or permeability of the tissue or tumour under investigation. Despite the availability of advanced experimental methods and phantoms to test the accuracy of blood flow and transfer rates, the reliable estimation of tissue permeability following kinetic modeling against a known truth is still outstanding. This work reports on the first two phases of the development of a tissue mimicking permeable hepatic perfusion phantom being tested under DCE-CT: material selection and fabrication, as well as property testing. The required properties of these synthetic materials include a tailored porous structure, tumor mimicking pore size and tumor mimicking permeability. Three phantom materials were investigated for their capabilities to address these requirements, i.e. polydimethylsiloxane (PDMS), thermoplastic polyurethane (TPU) and agar gel. Porous structures were made using different techniques such as phase separation micro-molding (for PDMS) and a particular leaching process (for PDMS and TPU). Manual pores were made on agar gel and all were characterized under SEM, micro-CT scan and pycnometer. TPU was selected as the phantom material of choice moving forward due to its high homogeneity in pore size ranging from 200 to 400 μm, which mimics tumor vasculature the best. TPU also has the highest permeability of the three materials and its stable structure provides good repeatability.

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Improved accuracy of quantitative parameter estimates in dynamic contrast-enhanced CT study with low temporal resolution

Cited by 2 publications

References 47 publications

Basis and current state of computed tomography perfusion imaging: a review

Basis and current state of computed tomography perfusion imaging: a review

Development of a permeable phantom for dynamic contrast enhanced (DCE) imaging quality assurance: material characterization and testing

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