2000
DOI: 10.1002/1522-2586(200008)12:2<347::aid-jmri19>3.3.co;2-z
|View full text |Cite
|
Sign up to set email alerts
|

Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors

Abstract: We describe a new method to allow simultaneous mapping of endothelial permeability and blood volume in intracranial lesions. The technique is based on a tumor leakage profile during the first pass (fp) of contrast bolus calculated from the time-dependent plasma-contrast concentration function (PCCF) in three-dimensional (3D) T1-weighted dynamic studies. The performance of the method has been evaluated by comparing results with those obtained from more conventional methods in patients with primary brain neoplas… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

4
87
0

Year Published

2000
2000
2006
2006

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 43 publications
(91 citation statements)
references
References 11 publications
4
87
0
Order By: Relevance
“…These strategies allowed rapid volume acquisition, suitable for DCE-MRI studies. Native tissue T 1 values were determined prior to contrast agent administration from three acquisitions with three different flip angles (␣ ϭ 2°, 10°, 35°) (14,15). The dynamic series utilized the same three-dimensional acquisition (TR, TE, FOV, matrix identical), with ␣ ϭ 35°, repeated to cover between three and six minutes.…”
Section: Sitementioning
confidence: 99%
See 2 more Smart Citations
“…These strategies allowed rapid volume acquisition, suitable for DCE-MRI studies. Native tissue T 1 values were determined prior to contrast agent administration from three acquisitions with three different flip angles (␣ ϭ 2°, 10°, 35°) (14,15). The dynamic series utilized the same three-dimensional acquisition (TR, TE, FOV, matrix identical), with ␣ ϭ 35°, repeated to cover between three and six minutes.…”
Section: Sitementioning
confidence: 99%
“…The temporal resolution of the acquisition was approximately eight seconds, and images were acquired contiguously in time. Scanner transmitter and receiver gains were kept constant throughout both the baseline T 1 calculation and the dynamic series to facilitate signal comparisons for determination of contrast agent concentration (15,16). Contrast agent (0.1 mmol/kg of gadodiamide: Gd-DTPA-BMA [Omniscan, Nycomed, Norway]) was administered manually by an experienced neuroradiologist following the seventh dynamic scan.…”
Section: Sitementioning
confidence: 99%
See 1 more Smart Citation
“…As a practical example of these choices, the models were each fitted to recent experimental data (input and tissue residue curves) acquired in a meningioma (12), shown in Fig. 4.…”
Section: Implications For Tracer Kinetic Studiesmentioning
confidence: 99%
“…Given this, the following analyses assume that the arterial input function has been measured. Although techniques to achieve this are not yet in common use, an increasing number of investigators are developing practical methods for doing so (11,12). …”
mentioning
confidence: 99%