Imprinted Polymers in Chemical Recognition for Mass-Sensitive Devices

Dickert, Franz L.; Lieberzeit, Peter A.

doi:10.1007/978-3-540-36568-6_5

Cited by 10 publications

(9 citation statements)

References 73 publications

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“…A “gate effect” , accompanying analyte binding to a MIP film can be detected by conductivity measurements. Mechanical changes of the polymer layer (including its mass and acoustic thickness) lead to broad applications of TSM transducers − for sensing with MIP films. Fluorescent sensing can be used for detection of fluorescent analytes in competitive assays , or in fluorescent MIPs. , Electrochemical techniques can be applied for direct detection of electrochemically active analytes or for replacement of electrochemically active markers in competitive assays. − Other detection approaches include colorimetric, , calorimetric, and ISFET. , In addition to the use of various sensing platforms, detailed investigations of affinity of MIPs are performed by HPLC.…”

Section: 5 Molecularly Imprinted Polymersmentioning

confidence: 99%

Combinatorial and High-Throughput Development of Sensing Materials: The First 10 Years

2008

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Section: 5 Molecularly Imprinted Polymersmentioning

confidence: 99%

Combinatorial and High-Throughput Development of Sensing Materials: The First 10 Years

2008

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“…An interesting alternative approach consists of the design of sensors functionalized with molecularly-imprinted polymer (MIP) for the selective detection of glyphosate. The rationale of this strategy is related to the fact that molecular imprinting is low-cost, sensitive, selective, specific, and versatile [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Selective Polypyrrole MIP-Based Gravimetric and Electrochemical Sensors for Picomolar Detection of Glyphosate

Mazouz¹,

Rahali

Fourati

et al. 2017

Sensors

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There is a global debate and concern about the use of glyphosate (Gly) as an herbicide. New toxicological studies will determine its use in the future under new strict conditions or its replacement by alternative synthetic or natural herbicides. In this context, we designed biomimetic polymer sensing layers for the selective molecular recognition of Gly. Towards this end, complementary surface acoustic wave (SAW) and electrochemical sensors were functionalized with polypyrrole (PPy)-imprinted polymer for the selective detection of Gly. Their corresponding limits of detection were on the order of 1 pM, which are among the lowest values ever reported in literature. The relevant dissociation constants between PPy and Gly were estimated at [Kd1 = (0.7 ± 0.3) pM and Kd2 = (1.6 ± 1.4) µM] and [Kd1 = (2.4 ± 0.9) pM and Kd2 = (0.3 ± 0.1) µM] for electrochemical and gravimetric measurements, respectively. Quantum chemical calculations permitted to estimate the interaction energy between Gly and PPy film: ΔE = −145 kJ/mol. Selectivity and competitivity tests were investigated with the most common pesticides. This work conclusively shows that gravimetric and electrochemical results indicate that both MIP-based sensors are perfectly able to detect and distinguish glyphosate without any ambiguity.

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“…The operation of the QCM sensor is based on the so-called gravimetric technique [1], which reports the changes in mass on the sensor surface by shifting the resonant frequency. The QCM sensor is extensively used in biochemical detection: immunoassays, protein adsorption, and parameter DNA hybridization [16][17][18]. Based on the measurement of the dissipation parameter (QCM-D), the viscoelastic and conformational properties of the sample [19] are also monitored.…”

Section: Introductionmentioning

confidence: 99%

Quartz Crystal Microbalance with Impedance Analysis Based on Virtual Instruments: Experimental Study

Burda

2022

Sensors

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The impedance quartz crystal microbalance (QCMI) is a versatile and simple method for making accurate measurements of the QCM sensor electrical parameters. The QCM sensor provides access to the physical parameters of the sample beyond the mass per unit area by measuring the dissipation factor, or another equivalent, ensuring a detailed analysis of the surface. By establishing a cooperative relationship between custom software and modular configurable hardware we obtain a user-defined measurement system that is called a virtual instrument. This paper aims primarily to improve and adapt existing concepts to new electronics technologies to obtain a fast and accurate virtual impedance analyzer (VIA). The second is the implementation of a VIA by software to cover a wide range of measurements for the impedance of the QCM sensor, followed by the calculation of the value of lumped electrical elements in real time. A method for software compensation of the parallel and stray capacitance is also described. The development of a compact VIA with a decent measurement rate (192 frequency points per second) aims, in the next development steps, to create an accurate impedance analyzer for QCM sensors. The experimental results show the good working capacity of QCMI based on VIA.

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Imprinted Polymers in Chemical Recognition for Mass-Sensitive Devices

Cited by 10 publications

References 73 publications

Combinatorial and High-Throughput Development of Sensing Materials: The First 10 Years

Combinatorial and High-Throughput Development of Sensing Materials: The First 10 Years

Highly Selective Polypyrrole MIP-Based Gravimetric and Electrochemical Sensors for Picomolar Detection of Glyphosate

Quartz Crystal Microbalance with Impedance Analysis Based on Virtual Instruments: Experimental Study

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