Imprinted gene expression in fetal growth and development

Lambertini, Luca; Marsit, Carmen J.; Sharma, Priyanka; Maccani, Matthew A.; Ma, Yizhou; Hu, Jianzhong; Chen, Jia

doi:10.1016/j.placenta.2012.03.001

Cited by 43 publications

(28 citation statements)

References 41 publications

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“…[22][23][24][25] In this study, we demonstrated that there is variability in the extent of DNA methylation of the promoter region for the HTR2A gene, which is associated with alterations in gene expression. 19 This receptor has been noted to serve a mitogenic role in placental cells, and there may be additional physiologic roles for this receptor and general serotonergic tone within the placenta during development, particularly when this tissue acts as a source of serotonin.…”

Section: Discussionmentioning

confidence: 63%

PlacentalHTR2Amethylation is associated with infant neurobehavioral outcomes

et al. 2013

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Section: Discussionmentioning

confidence: 63%

PlacentalHTR2Amethylation is associated with infant neurobehavioral outcomes

et al. 2013

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“…Our prior work had suggested that the expression of these genes can be correlated, 21,22 and, often, the reliance of multiple imprinted genes on single imprinting control regions could be underlying this phenomenon, at least in some cases. 23 Dimension reduction using a factor analysis confirmed these observations in this larger gene set and population and revealed several important trends in the data.…”

Section: Discussionmentioning

confidence: 99%

Placental expression profile of imprinted genes impacts birth weight

et al. 2015

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The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association between the placental expression of 108 established and putative imprinted genes and birth weight in 677 term pregnancies, oversampled for small for gestational age (SGA) and large for gestational age (LGA) infants. Using adjusted multinomial regression analyses, a 2-fold increase in the expression of 9 imprinted genes was positively associated with

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“…13 Importantly, the placenta and brain are the 2 organs that have the most active imprinted genome because both organs are under tremendous selective pressure to optimize growth and development, and both are thought to have undergone co-adaptation, leading to co-expression of many of the same imprinted genes. 13,25 Although the expression of imprinted genes is highly regulated, our group and others have demonstrated subtle variation in the expression of these genes in the placenta of healthy newborns 15,26,27 ; yet, little is known about the relationships between this variation in expression and newborn and childhood outcomes. We demonstrated that infants with specific, coordinated profiles of expression of subset of imprinted genes in the placenta were at increased risk for sub-optimal performance on measures of movement quality and for exhibiting an elevated number of signs of physiologic stress of abstinence.…”

Section: Discussionmentioning

confidence: 99%