Impression Cytologic Analysis After Corneal Collagen Cross-Linking Using Riboflavin and Ultraviolet- A Light in the Treatment of Keratoconus

Renesto, Adimara da Candelária; Barros, João; Campos, Mauro

doi:10.1097/ico.0b013e3181d4f91a

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study (4) , a reduction in goblet cell density on the superior conjunctiva was observed after the CXL. The follow-up period was only 3 months, and the authors related this finding to factors such as the toxicity of the topical medication and inflammation or mechanical damage from the lid speculum.…”

Section: Discussionmentioning

confidence: 74%

“…Recently, an optical microscopic study (4) by our group demonstrated that despite changes in goblet cell density after corneal CXL in the superior conjunctiva and an improvement in the morphology of epithelial cells after the use of RE, the morphology grade of the most superficial epithelial cells obtained by IC from the cornea and bulbar conjunctiva did not change after CXL using riboflavin and UVA light in the treatment of keratoconus. This finding suggests that the CXL is a safe procedure at the 3-month follow-up.…”

Section: Discussionmentioning

confidence: 91%

“…Despite being an evolutive disease, CXL has recently been utilized as a therapeutic option for stabilizing the cornea (1) . An optical microscopic study (4) demonstrated that the morphology grade of the most superficial epithelial cells obtained by impression cytology (IC) from the cornea and bulbar conjunctiva did not change after CXL using riboflavin and ultraviolet-A (UVA) light in the treat ment of keratoconus.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impression cytologic analysis after corneal cross-linking and insertion of corneal ring segments for keratoconus: two-year results

Renesto¹,

Barros²,

Campos³

2012

Arq. Bras. Oftalmol.

Self Cite

View full text Add to dashboard Cite

Purpose: To report the impression cytologic results after corneal cross-linking and insertion of intrastromal corneal ring segments for keratoconus. Methods: Thirty-nine eyes were distributed into two groups: 1) cross-linking group (patients underwent corneal cross-linking procedure), and 2) riboflavin eyedrops group (patients received 0.1% riboflavin (w/v) eyedrops in 20% dextran solution for 1 month). After 3 months, all patients underwent insertion of intrastromal corneal ring segments. Impression cytologic specimens were obtained from all eyes at baseline, at 1 month and 3 months after cross-linking or riboflavin eyedrops, and again at 6 months, 1 year, and 2 years after intrastromal corneal ring segment insertion. Results: Patients in the cross-linking group demonstrated improvement in the cellto-cell contact of epithelial cells and the nucleus-to-cytoplasm ratio on the temporal conjunctiva after treatment (P=0.008 and P=0.047), respectively. On the superior conjunctiva, increases in goblet cell density (P=0.037) and level of organization of nuclear chromatin (P=0.010) after treatment were noted. Patients in the riboflavin eyedrops group demonstrated improvement in the cell-to-cell contact of epithelial cells on the superior conjunctiva after treatment (P=0.021). On the temporal conjunctiva, an improvement in the cell-to-cell contact of epithelial cells (P<0.001) and increases in the nucleus-to-cytoplasm ratio (P<0.001), goblet cell density (P=0.001), and less keratinization (P=0.011) were noted. No changes were identified on the cornea for either group. Fisher's exact test comparison of the impression cytologic total scores after treatment revealed no difference between groups. Conclusion: Despite changes in some conjunctival parameters (e.g., cell-to-cell con tact of epithelial cells, nucleus-to-cytoplasm ratio, level of organization of nuclear chro matin, goblet cell density, and keratinization), comparison of the total impression cytologic scores revealed no difference between groups.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impression cytologic analysis after corneal cross-linking and insertion of corneal ring segments for keratoconus: two-year results

Renesto¹,

Barros²,

Campos³

2012

Arq. Bras. Oftalmol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…На основании обширной экспериментальной базы во многих странах мира было с успехом начато внедрение процедуры «кросс-линкинга» в клиническую практику. Многочисленные исследования подтвердили безопасность и эффективность данного метода [9][10][11][12][13][14].…”

unclassified

Long-term efficacy of corneal collagen cross-linking in patients with progressive keratoconus

Kuznetsov

Zelyanina

2015

Vestn. oftal'mol.

View full text Add to dashboard Cite

show abstract

Reshaping procedures for the surgical management of corneal ectasia

Ziaei

Barsam

Shamie

et al. 2015

Journal of Cataract and Refractive Surgery

102

100

View full text Add to dashboard Cite

show abstract

Impression Cytologic Analysis After Corneal Collagen Cross-Linking Using Riboflavin and Ultraviolet- A Light in the Treatment of Keratoconus

Abstract: Despite changes in goblet cell density after corneal CXL in the superior conjunctiva and an improvement in the morphology of epithelial cells after the use of riboflavin eyedrops, comparison of total IC scores showed no difference between groups.

Cited by 6 publications

References 25 publications

Impression cytologic analysis after corneal cross-linking and insertion of corneal ring segments for keratoconus: two-year results

Impression cytologic analysis after corneal cross-linking and insertion of corneal ring segments for keratoconus: two-year results

Long-term efficacy of corneal collagen cross-linking in patients with progressive keratoconus

Reshaping procedures for the surgical management of corneal ectasia

Contact Info

Product

Resources

About