Impression 3D en médecine régénératrice et ingénierie tissulaire

Fricain, Jean-Christophe; Olivera, Hugo De; Devillard, Raphaël; Kalisky, Jérôme; Rémy, Murielle; Kériquel, Virginie; Nihounen, Damien Le; Grémare, Agathe; Gudurić, Vera; Plaud, Alexis; L’Heureux, Nicolas; Amédée, Joëlle; Catros, Sylvain

doi:10.1051/medsci/20173301009

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…Bio-printing is a biomedical application using the principles of 3D printing to artificially produce living biological tissue. Bio-printing is a fast-growing field today because its potential applications are vast and promising in the medical field as well as in research 58 . Itoh et al have used this technology to produce a TEVG in 4 days by assembling 500 multicell spheroids as a tube of 1.5 mm inner diameter and 7 mm in length 59 .…”

Section: Preclinical Trialsmentioning

confidence: 99%

Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Fayon

Omar

2021

npj Regen Med

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Due to the lack of efficacy of synthetic vascular substitutes in the replacement of small-caliber arteries, vascular tissue engineering (VTE) has emerged as a promising solution to produce viable small-caliber tissue-engineered vascular grafts (TEVG). Previous studies have shown the importance of a cellular intimal layer at the luminal surface of TEVG to prevent thrombotic events. However, the cellularization of a TEVG seems to be a critical approach to consider in the development of a TEVG. To date, no standard cellularization method or cell type has been established to create the ideal TEVG by promoting its long-term patency and function. In this review, advances in VTE are described and discussed with a particular focus on the construction approaches of cellularized small-caliber TEVGs, the cell types used, as well as their preclinical and clinical applications.

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Section: Preclinical Trialsmentioning

confidence: 99%

Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Fayon

Omar

2021

npj Regen Med

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“…Various techniques are being considered, such as contact printing, inkjet or extrusion [153]. The development of bioprinting applications has led to the emergence of several companies that operate under three main business models [154]: manufacturing and sale of bioprinters, sale of bioprinting services, or partnership with a customer on a specific application.…”

Section: Femtosecond Laser-induced Bulk Modification In Transparent Materials For Biological Applicationsmentioning

confidence: 99%

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

et al. 2021

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Driven by flexibility, precision, repeatability and eco-friendliness, laser-based technologies have attracted great interest to engineer or to analyze materials in various fields including energy, environment, biology and medicine. A major advantage of laser processing relies on the ability to directly structure matter at different scales and to prepare novel materials with unique physical and chemical properties. It is also a contact-free approach that makes it possible to work in inert or reactive liquid or gaseous environment. This leads today to a unique opportunity for designing, fabricating and even analyzing novel complex bio-systems. To illustrate this potential, in this paper, we gather our recent research on four types of laser-based methods relevant for nano-/micro-scale applications. First, we present and discuss pulsed laser ablation in liquid, exploited today for synthetizing ultraclean “bare” nanoparticles attractive for medicine and tissue engineering applications. Second, we discuss robust methods for rapid surface and bulk machining (subtractive manufacturing) at different scales by laser ablation. Among them, the microsphere-assisted laser surface engineering is detailed for its appropriateness to design structured substrates with hierarchically periodic patterns at nano-/micro-scale without chemical treatments. Third, we address the laser-induced forward transfer, a technology based on direct laser printing, to transfer and assemble a multitude of materials (additive structuring), including biological moiety without alteration of functionality. Finally, the fourth method is about chemical analysis: we present the potential of laser-induced breakdown spectroscopy, providing a unique tool for contact-free and space-resolved elemental analysis of organic materials. Overall, we present and discuss the prospect and complementarity of emerging reliable laser technologies, to address challenges in materials’ preparation relevant for the development of innovative multi-scale and multi-material platforms for bio-applications.

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“…The development of new functional printable materials and 3D printing technologies has transformative potential in a variety of fields such as optics and photonics, − bioengineering, − (micro)robotics, − and many more. − Among those functional materials, liquid crystals (LCs) have been widely explored due to their intrinsic anisotropy as well as their stimuli-responsive and self-healing properties. , Within the vast variety of LCs, nematic LCs (NLCs) consisting of rod-shaped LC molecules have been extensively exploited over the last few decades: from LC displays to stimuli-responsive devices such as actuators and more recently in 3D/4D printing. − In particular, NLC-based materials have been successfully printed using different technologies, including direct ink writing, − fused deposition modelling, , inkjet printing, , and very recently, employing two-photon 3D laser printing. 3D laser printing (also known as direct laser writing) has been established as an excellent tool for the fabrication of functional objects down to sub-micron resolution. , Recent studies using this technology have demonstrated the potential of NLCs for applications in tunable microoptics , or as microscopic actuators. − …”

Section: Introductionmentioning

confidence: 99%

Two-Photon Laser Microprinting of Highly Ordered Nanoporous Materials Based on Hexagonal Columnar Liquid Crystals

Monti

Concellón

Dong

et al. 2022

ACS Appl. Mater. Interfaces

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Nanoporous materials relying on supramolecular liquid crystals (LCs) are excellent candidates for size- and charge-selective membranes. However, whether they can be manufactured using printing technologies remained unexplored so far. In this work, we develop a new approach for the fabrication of ordered nanoporous microstructures based on supramolecular LCs using two-photon laser printing. In particular, we employ photo-cross-linkable hydrogen-bonded complexes, that self-assemble into columnar hexagonal (Colh) mesophases, as the base of our printable photoresist. The presence of photopolymerizable groups in the periphery of the molecules enables the printability using a laser. We demonstrate the conservation of the Colh arrangement and of the adsorptive properties of the materials after laser microprinting, which highlights the potential of the approach for the fabrication of functional nanoporous structures with a defined geometry. This first example of printable Colh LC should open new opportunities for the fabrication of functional porous microdevices with potential application in catalysis, filtration, separation, or molecular recognition.

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Impression 3D en médecine régénératrice et ingénierie tissulaire

Cited by 11 publications

References 35 publications

Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard

Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

Two-Photon Laser Microprinting of Highly Ordered Nanoporous Materials Based on Hexagonal Columnar Liquid Crystals

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