Impregnation of mesenchymal stem cell secretome with Wortmannin inhibits the proliferation of breast cancer cells via PI3K/Akt/mTOR pathway
Doha F. Ismail,
Mai M. El- Keey,
Saad M. Elgendy
et al.
Abstract:The utilization of Mesenchymal stem cells (MSCs)-derived secretome was suggested as a promising alternative in cell-based regenerative therapy. Herein, the MSCs cells were impregnated with a pan-PI3K/Akt/mTOR inhibitor and their secretome was utilized to explore the anticancer and antimetastasis effects against breast cancer. To establish this aim Bone marrow-derived MSCs was treated with 50, 100, or 250 nM Wortmannin (Wort), where the cytotoxic, apoptotic, and autophagic potential of their secretome were inve… Show more
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