Impossible crystals snag chemistry Nobel

Noorden, Richard Van

doi:10.1038/news.2011.572

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…In spite of this observation, de Boissieu wrote that three-dimensional Penrose tiling (3DPT) can be generated by the six-dimensional cut method (E 6 → E 3 1 + E 3 2 , where E 3 1 ⊥E 3 2 , rhombohedra with four edges perpendicular to a fixed face of the dodecahedron) and that such "parallel" components have been experimentally observed for the first time [9]. However, icosahedral aperiodic tiling are well described as solid quasicrystal (alloys of three or more elements: Al, Mn, Fe, and Cr) by Dan Shechtman, who received the Nobel prize for chemistry in 2011 [10][11][12]. Based on theoretical and experimental results, it is shown that soft-matter quasicrystals with icosahedral symmetry may exist in biological systems [13].…”

Section: Introductionmentioning

confidence: 99%

The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine

Matija,

Stankovic,

Puric

et al. 2023

Micromachines

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The human body contains 60–70% water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent hydrogen bonds. Water molecules, by themselves (in vacuum), are diamagnetic but when organized into clusters, they become diamagnetic or paramagnetic. Also, biomolecules (DNA, collagen, clathrin, and other proteins) have non-covalent hydrogen bonds in their structure. The interaction, as well as signal transmission, between water and biomolecules is achieved through the vibrations of covalent and non-covalent hydrogen bonds, which determine the state and dynamics of conformational changes in biomolecules. Disruptive conformational changes in biomolecules, cells, and tissues lead to their dysfunctionality, so they are a frequent cause of many disorders and diseases. For example, the rearrangement of hydrogen bonding due to mitochondrial disease mutation in cytochrome bc1 disturbs heme bH redox potential and spin state. In order to prevent and repair the dysfunctional conformational changes, a liquid substance was developed based on the second derivative of the C60 molecule (SD-C60), which has classical and quantum properties. The characterization of SD-C60 by UV-VIS-NIR, FTIR, TEM, and AFM/MFM was performed and it is shown that SD-C60 water layers generate vibrations with near-zero phase dispersion which are transmitted through Fibonacci’s water chains to biomolecules. In comparison with previously published SD-C60 derivate (3HFWC, size until 10 nm, and 1–5 water layers), the improved formulation (3HFWC-W, size 10–25 nm, and 6–9 water layers) showed multiplied cytotoxic activity against melanoma cell lines of different aggressiveness. Apart from this, the mode of action was preserved and based on an induction of senescence rather than cell death. Importantly, high selectivity towards malignant phenotypes was detected. Observed effects can be ascribed to a machinery of hydrogen bonds, which are generated in SD-C60 and transmitted through water to biomolecules. This approach may open a new field in science and healthcare—a “water-based nanomedicine”.

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Section: Introductionmentioning

confidence: 99%

The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine

Matija,

Stankovic,

Puric

et al. 2023

Micromachines

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New Arguments for a pure lottery in Research Funding: A Sketch for a Future Science Policy Without Time-Consuming Grant Competitions

Roumbanis

2023

Minerva

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A critical debate has blossomed within the field of research policy, science and technology studies, and philosophy of science regarding the possible benefits and limitations of allocating extramural grants using a lottery system. The most common view among those supporting the lottery idea is that some form of modified lottery is acceptable, if properly combined with peer review. This means that partial randomization can be applied only after experts have screened the pursuit-worthiness of all submitted proposals and sorted out those of lowest quality. In the present paper, I will argue against the use of partial lotteries or partial randomization and instead promote use of a pure lottery in combination with a radical increase in block funding. The main reason for holding this position is that a partial lottery cannot solve the problems inherent in the current funding system, which is based on grant competitions and peer review. A partial lottery cannot decrease the enormous time-waste, reduce the uneven distribution of time between researchers, neutralize expert biases or mitigate academic power asymmetries. Instead, we need a stronger focus on improving general time management in academia by implementing a more holistic model for organizing research opportunities in the future.

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Post-buckling analysis of axially loaded two-dimensional quasicrystal cylindrical shells with initial geometric imperfection

Zhu

Sun

et al. 2023

Mechanics of Advanced Materials and Structures

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Impossible crystals snag chemistry Nobel

Cited by 4 publications

References 2 publications

The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine

The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine

New Arguments for a pure lottery in Research Funding: A Sketch for a Future Science Policy Without Time-Consuming Grant Competitions

Post-buckling analysis of axially loaded two-dimensional quasicrystal cylindrical shells with initial geometric imperfection

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