This is a mini-review of the effects of khat-leaves of which are chewed by people around the world. Khat chewing could have profound short and long-term effects on various human body systems, of which some of the main effects are discussed in this review. Although various countries recognize the potential harm of using khat, legal mechanisms controlling the use of khat vary widely. Nevertheless, medical professionals, psychiatrists, and social workers are required to be vigilant of the effects of khat use, manage these effects, and sign postrelevant cases to the appropriate professionals, if necessary. A range of clinically relevant issues, in addition to socioeconomic consequences, is discussed. An attempt has also been made to formulate a care plan that may be of benefit for treatment providers.