Important parameters to consider for the characterization of PET and SPECT imaging probes

Rules of thumb for maximum percent tumor accumulation

“…A co-injection of the blocking agent is recommended due to possible interference from its metabolites [9]. However, the reactor model suggests that a pre-injection would provide a higher blocking efficiency, although this hypothesis needs to be verified.…”

“…Investigations on the quantitative relationship between structure and effect are more appealing but they are usually based on numerous existing molecules. There are also some rough guidelines to ensure solid science and to avoid repetitive studies [9], but few investigations have provided insights into the success possibility in target selection. Favorably, the rule-of-thumb approach may provide rough ideas on the outcomes at early stage under different conditions.…”

Molecular Imaging and Contrast Agent Database (MICAD): Evolution and Progress

“…Ideally all MI and CAs published in peer-reviewed literature would be included in MICAD, but this is a monumental task as the list is constantly growing because a large number of new imaging agents (and novel techniques/modalities) are published every month and added to the MIP & CA list. Therefore, to promote the rapid expansion of the database and to foster participation by the imaging community in this undertaking, the MICAD editors implemented a program in 2007 to accept chapters from guest authors for publication in the database [1, 2]. Publishing in MICAD has several advantages over print publications because the chapters are available to the readers rapidly, access to the database is free and without subscription, circulation of the articles is worldwide through the internet and information can be printed from the database as necessary.…”

“…Publications used to write a chapter in MICAD should report sufficient details regarding the agent’s chemical or biological synthesis and must contain data obtained from animal or human studies. Information essentially expected in a publication that can be used to write a chapter for MICAD has been discussed earlier by Chopra et al [2]. Once published online, the MICAD editors from time-to-time update the information when new information or application(s) of the agent is published.…”

“…The database is a freely accessible online source of scientific information regarding molecular imaging (MI) probes and contrast agents (CAs) that have in vivo data published in peer reviewed journals [1, 2]. The primary mission of MICAD is to promote research, development, application and translation of molecular imaging research and techniques to the biological sciences and drug discovery for the rapid advancement of clinical sciences to detect, diagnose, treat and monitor various malignancies or pathological conditions in humans [3].…”