Important Factors for the Hearing Loss Caused by the Triple Semicircular Canal Occlusion in Guinea Pigs

Yin, Shankai; Yu, Dongzhen; Chen, Zhengnong; Cao, Zhenyu; Wang, Jian

doi:10.1097/mao.0b013e318033f020

Cited by 12 publications

(8 citation statements)

References 22 publications

(24 reference statements)

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“…Animal studies showed that various hearing impairments have been documented after TSCO, while single semicircular canal occlusion has been recognized as an efficient method of eliminating vertigo without causing a significant hearing impairment. 16 Meanwhile, in our animal models, the symptoms and compensatory period after USSCO were all similar to what have been reported in patients of intractable BPPV (benign paroxysmal positional vertigo) after surgery, which could improve imbalance symptoms in 94% of patients. 2 The model used in this experiment was proved to be simple and stable and could thus be used for the studies of the mechanisms of vestibular central compensation and acute unilateral peripheral vestibular lesion.…”

Section: Changes Of Behaviour and Eng After Unilateral Horizontal Sem...supporting

confidence: 86%

Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC–ECD

Zhang

et al. 2015

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Unilateral single semicircular canal occlusion (USSCO) is an effective treatment for some cases of intractable vertigo. All patients suffer behavioural imbalance caused by surgery, and then recover with a resumption of vestibular function. However, the compensation mechanism has not been fully evaluated. Findings suggest that serotonin (5-HT) is released from nerve terminals, and plays a vital role in the plasticity of the central nervous system. In this study, we performed surgery of unilateral single semicircular canal occlusion (USSCO) on guinea pigs, and investigated the change of 5-HT by in vivo microdialysis of the medial vestibular nucleus (MVN) coupled with high-performance liquid chromatography and electrochemical detection (HPLC-ECD). A total of 12 guinea pigs were divided randomly into two groups, namely the USSCO group and the control group. Animals in the USSCO group underwent surgery of lateral horizontal semicircular canal occlusion, and those in the control group experienced the same operation but just to expose the horizontal semicircular canal without occlusion. Vestibular disturbance symptoms were observed in the case of the USSCO group, e.g. head tilting, and forced circular movements and spontaneous nystagmus at postoperative days 1 and 3. The basal level of 5-HT was determined to be 316.78 ± 16.62 nM. It elevated to 448.85 ± 24.56 nM at one day following occlusion (P = 0.001). The increase was completely abolished with the vestibular dysfunction recovery. The results showed that unilateral horizontal semicircular canal occlusion could increase the 5-HT level in MVN. 5-HT may play a significant role in the process of central vestibular compensation with residual vestibular function.

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Section: Changes Of Behaviour and Eng After Unilateral Horizontal Sem...supporting

confidence: 86%

Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC–ECD

Zhang

et al. 2015

Analyst

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“…Therefore, beyond the mechanism of mechanical obstruction, further studies are required to explore the complex pathophysiological mechanisms of this phenomenon. Notably, TSCO can cause hearing loss of up to 30%, which may be associated with labyrinthitis and perilymph fistulae ( 10 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…TSCO was then performed as follows: A fenestration of about 2 mm was made in the central portion of the bony canal, as far away as possible from the ampulla, using a 1-mm drill and a hook to pry off the bone, without opening the endosteum or the membranous labyrinth. Great care was taken to avoid injuring the membranous labyrinth as it can lead to serious hearing loss ( 10 ). The temporalis fascia, bone dust collected during the procedure, and fibrinogen glue were inserted through the fenestra to compress the endosteum and membranous labyrinth against the bony back wall.…”

Section: Case Reportmentioning

confidence: 99%

Case Report: Preservation of Otolithic Function After Triple Semicircular Canal Occlusion in a Patient With Intractable Ménière Disease

et al. 2021

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Operative measures are considered when medical treatment fails to control vertigo in patients with intractable Ménière disease. The present report discusses a case in which triple semicircular canal occlusion was performed in a 30-year-old female patient who responded poorly to previously performed endolymphatic sac surgery. Her vestibular and auditory functions were evaluated both before and after surgery. Class A control of vertigo was achieved during the 76-month postoperative follow-up period. Ocular and cervical vestibular evoked myogenic potentials could be elicited before and after surgery. This case suggests that relatively long-term preservation of otolithic function can be achieved following triple semicircular canal occlusion, highlighting its potential as an alternative treatment for patients with Ménière disease.

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“…Opening and plugging an SSC, with or without opening the membranous labyrinth, carries a definite risk of sensorineural hearing loss, even in noninflamed, noninfectious ears, as documented by reports on use of the surgical technique in cases of SSC dehiscence 18 and by animal studies. 19 Moreover, opening the SSC in an inflamed ear with chole steatoma could enhance the risk of labyrinthitis and its ensuing sensorineural hearing loss. In selected cases, our technique provides fairly good visibility and offers excellent odds for hearing preservation, because the membranous labyrinth remains untouched.…”

Section: Discussionmentioning

confidence: 99%

Subarcuate Supralabyrinthine Approach for Supralabyrinthine Petrosal Cholesteatoma

Dinther¹,

Vercruysse²,

Foer³

et al. 2010

Ann Otol Rhinol Laryngol

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Congenital cholesteatomas of the petrosal apex account for 1% to 3% of all cholesteatomas and often present an important surgical challenge. This report describes an exceptional case of a "nondestructive" translabyrinthine surgical approach to a large congenital petrosal cholesteatoma that threatened the vestibulum, superior semicircular canal, facial nerve, and internal auditory canal. We applied a nonconventional transmastoid subarcuate supralabyrinthine approach in a 20-year-old patient by accessing the lesion through the center of the superior semicircular arch without damaging the integrity of the canal. This led to a complete removal of the petrosal cholesteatoma with preservation of hearing and vestibular function. Follow-up imaging performed 1 and 2 years after operation by means of non-echo-planar diffusion-weighted imaging did not show residual cholesteatoma. This report describes the first successful use of a subarcuate supralabyrinthine approach through the arches of the superior semicircular canal in a case of petrosal cholesteatoma.

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Important Factors for the Hearing Loss Caused by the Triple Semicircular Canal Occlusion in Guinea Pigs

Abstract: Hearing loss caused by TSCO can be greatly reduced by avoiding damage to the membranous labyrinth and by shortening the operation time.

Cited by 12 publications

References 22 publications

Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC–ECD

Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC–ECD

Case Report: Preservation of Otolithic Function After Triple Semicircular Canal Occlusion in a Patient With Intractable Ménière Disease

Subarcuate Supralabyrinthine Approach for Supralabyrinthine Petrosal Cholesteatoma

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