Important decrease in invariant natural killer T, CD4+ regulatory T cells, CD8+ regulatory T cells, gamma–delta T cells, and CD4+ T lymphocytes in HIV-negative patients with hemophilia
Abstract:Hereditary hemophilias are X-linked inherited bleeding disorders defined as deficiencies of the coagulation factors VIII or IX. They are characterized by easy to provoke or spontaneous bleeding. HIV infection in hemophilic patients is a risk factor for the reduction of CD4+ T cells. There is no information regarding the cellular immune function in HIV-negative patients with hemophilia. To evaluate the number of lymphocyte subsets in adult patients with hemophilia A or B as compared with healthy donors. 39 Adul… Show more
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