Importancia del estudio gammagráfico óseo en el diagnóstico del síndrome de SAPHO

Rodríguez, M. Vázquez; Tormo, I. Casáns; Peña, M.C. Redal; Castillo, V. Lopez

doi:10.1016/j.remn.2010.01.001

Cited by 11 publications

(5 citation statements)

References 12 publications

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“…Symmetric uptake in the sternoclavicular region with a typical “bull‘s head” appearance shown in bone scintigraphy is characteristic of the SAPHO syndrome (Fig. 3 ) [ 46 ]. It was first described by Freyschmidt and Sternberg [ 47 ] but, even though it is considered to be pathognomonic, it is not a very sensitive indicator of SAPHO.…”

Section: Radiological Featuresmentioning

confidence: 99%

“…When only one site is involved in the absence of skin lesions, making the diagnosis can be difficult and biopsy may be needed. Sterile osteitis (little or no medullary change) is one of the major characteristics of this syndrome, but the diagnosis can never be done by histological results alone, and the advantage of biopsy is just to exclude other diagnoses [ 24 , 46 ].…”

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

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SAPHO syndrome: A review

Rukavina

2015

Journal of Children's Orthopaedics

175

167

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IntroductionSynovitis–acne–pustulosis–hyperostosis–osteitis (SAPHO) is an acronym for various osteoarticular and dermatological manifestations that can appear in the same patient. It is a rare syndrome, but since its awareness has increased, there have been more and more such reports in the literature.AimsThe objectives of this review are to summarize the current state of knowledge on pediatric and adult-onset SAPHO syndrome, and to discuss treatment strategies that should be considered.ResultsThe SAPHO syndrome can affect patients of any age, and its etiology is still not known. The syndrome has its cognizable radiological characteristics that are most important in making the diagnosis. There are several diagnostic criteria as well, but they need further validation. No standard treatment protocols are available and current treatment options are not evidenced-based due to the rarity of the syndrome. Therapy is empirical and aimed at easing pain and modifying the inflammatory process. It includes nonsteroidal anti-inflammatory drugs (NSAIDs) as the first-line agents. Antibiotics, corticosteroids, disease-modifying anti-rheumatic drugs, biologicals targeting tumor necrosis factor alpha or interleukin-1, and bisphosphonates have all been used with variable success. Surgery is reserved to treat complications. Even though it is a disease with good long-term prognosis, its treatment remains a challenge and the results are known to be disappointing, especially with the skin component of the disease.ConclusionIt is expected that these patients present at the time of diagnosis and the treatment should be as early, effective, and safe as possible in order to prevent osteoarticular progression and to limit the adverse events associated with pharmacological drugs.

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Section: Radiological Featuresmentioning

confidence: 99%

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

SAPHO syndrome: A review

Rukavina

2015

Journal of Children's Orthopaedics

175

167

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“…For diagnosis of SAPHO syndrome, whole-body scintigraphy is useful because in addition to increased tracer uptake in the affected bone, it also reveals clinically silent lesions. The bull's head sign is the pathognomonic of SAPHO syndrome which is characterized by manubrium sterni which represents the upper skull and the inflamed sternoclavicular joint with the adjacent clavicle representing the horns [ 25 ]. Though this sign is pathognomonic for SAPHO syndrome, it is not sensitive [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome Masquerading as Metastatic Breast Cancer

Malik

Handa

Petraszko

et al. 2018

Case Reports in Rheumatology

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SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made.

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“…The clues for the diagnosis of our patient stemmed from systemic examination, radiological examination, and bone scintigraphy, which has been reported to be a sensitive and accurate early diagnostic test for bone lesions of SAPHO syndrome. [ 20 , 21 ] It had been reported that the hip joint is not usually involved in SAPHO syndrome. [ 3 , 7 ] Our patient had severe right hip pain associated with limited range of motion, and imaging studies demonstrated joint obliteration with severe arthritic change and myositis around the hip joint.…”

Section: Discussionmentioning

confidence: 99%

A case report of severely damaged hip joint caused by SAPHO syndrome treated with 2-stage total hip arthroplasty

et al. 2016

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Introduction:Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an increasingly recognized entity. The hip joint is known as a less frequently affected site in SAPHO syndrome, and there has been limited reports about hip joint diseases caused by SAPHO syndrome, and as such adequate treatment for this disease spectrum is still not fully elucidated.Case:We describe the case of a 52-year-old man admitted for SAPHO syndrome who went on to be diagnosed with advanced secondary hip arthritis associated with disabling right hip pain. The diagnosis of SAPHO syndrome was delayed; the patient was given a clinical diagnosis of osteomyelitis and treated with prolonged courses of antibiotics and open surgical debridement at previous tertiary health facility. The patient underwent 2-stage joint replacement surgery in our hospital. At 1 year after the surgery, he is well, with minimal right hip pain and the prosthesis is functioning well.Conclusion:This case shows the safety and effectiveness of the 2-stage joint replacement in treating destructive hip disease caused by SAPHO syndrome mimicking infectious arthritis.

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Importancia del estudio gammagráfico óseo en el diagnóstico del síndrome de SAPHO

Cited by 11 publications

References 12 publications

SAPHO syndrome: A review

SAPHO syndrome: A review

SAPHO Syndrome Masquerading as Metastatic Breast Cancer

A case report of severely damaged hip joint caused by SAPHO syndrome treated with 2-stage total hip arthroplasty

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