Importância de polimorfismos de genes reguladores de citocinas em transplantes de células progenitoras hematopoiéticas

Visentainer, Jeane Eliete Laguila; Sell, Ana Maria; Lieber, Sofia Rocha; Souza, Cármino Antônio de

doi:10.1590/s1516-93322008000400021

Cited by 4 publications

(8 citation statements)

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“…[3][4][5][6][7][8][9][10][11][18][19][20][21][22][23][24] Our analysis investigated the role of class I and II HLA variants on GVHD development in a population of 176 patients, and suggests that these were determinants for acute and chronic GVHD in allogenic HSCT patients with an HLA-identical sibling donor. HLA-A26 (a split of HLA-A10) was associated with higher risk of acute GVHD, in agreement with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation

et al. 2012

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CONTEXT AND OBJECTIVE: Graft-versus-host disease (GVHD) is one of the complications following allogenic stem cell transplantation. This study investigated an association between human leukocyte antigen (HLA) and the occurrence of acute and chronic GVHD in patients who had received stem cell transplantations from HLA-identical siblings. DESIGN AND SETTING: Retrospective study at Hematology and Hemotherapy Center, Universidade Estadual de Campinas (Unicamp). METHODS:The participants were 176 patients whose first transplant was between 1997 and 2009. HLA genotyping was performed serologically and using the polymerase chain reaction with specific primer sequence. RESULTS: Acute GVHD was positively associated with HLA-A10 (P = 0.0007), HLA-A26 (P = 0.002), B55 (P = 0.001), DRB1*15 (P = 0.0211) and DQB1*05 (P = 0.038), while HLA-B16 (P = 0.0333) was more frequent in patients without acute GVHD. Chronic GVHD was positively associated with HLA-A9 (P = 0.01) and A23 (P = 0.0292) and negatively with HLA-A2 (P = 0.0031) and B53 (P = 0.0116). HLA-B35 (P = 0.0373), B49 (P = 0.0155) and B55 (P = 0.0024) were higher in patients with acute GVHD grade 3 or above, than in other patients. In patients with extensive chronic GVHD, HLA-A9 (P = 0.0004), A24 (P = 0.0059) and A26 (P = 0.0411) were higher than in other patients, while HLA-A2 was lower (P = 0.0097).CONCLUSION: This study suggests that HLA can influence the incidence and severity of acute and chronic GVHD. However, a study with a better design and more patients will be needed to confirm these results. RESULTADOS: A DECH aguda foi associada positivamente com HLA-A10 (P = 0,0007), HLA-A26 (P = 0,002), B55 (P = 0,001), DRB1*15 (P = 0,0211) e DQB1*05 (P = 0,038), enquanto HLA-B16 (P = 0,0333) foi mais frequente em pacientes sem DECH aguda. A DECH crônica foi associada positivamente com HLA-A9 (P = 0,01) e A23 (P = 0,0292) e, negativamente, com HLA-A2 (P = 0,0031) e B53 (P = 0,0116). HLA-B35 (P = 0,0373), B49 (P = 0,0155) e B55 (P = 0,0024) estavam aumentados em pacientes com DECH aguda grau 3 ou maior, em comparação aos outros pacientes. Em pacientes com DECH crônica extensa, HLA-A9 (P = 0,0004), A24 (P = 0,0059) e A26 (P = 0,0411) estavam aumentados em comparação aos outros pacientes, enquanto HLA-A2 estava diminuído (P = 0,0097). CONCLUSÕES: Este estudo sugere que o HLA pode influenciar a ocorrência de DECH aguda e crônica e a sua gravidade. No entanto, um estudo com melhor desenho e com mais pacientes será necessário para confirmar esses resultados. RESUMO

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Section: Discussionmentioning

confidence: 99%

Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation

et al. 2012

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“…The SNPs in cytokine genes are known due to their association in several diseases (49,50) , as well as their influence on the production of antibodies in autoimmune diseases (51) . Most of the SNPs studied are in promoter regions and in the exon itself, or in microsatellites of intron regions (48) .…”

Section: Factors Predisposing Patients To the Development Of Factor Vmentioning

confidence: 99%

Importance of immune response genes in hemophilia A

Alencar¹,

Macedo²,

Barros³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII causing it to be recognized by the immune system as a foreign peptide. This is the most serious complication in hemophilia patients in respect to replacement therapy. Some studies have suggested that genetic factors influence the development of factor VIII inhibitors such as ethnicity, family history, mutations in the factor VIII gene and in genes of the immune system. The aim of this study was to conduct a literature review to assess the influence of genetic factors of immune response genes, especially genes of the major histocompatibility complex and cytokines, which may be related to the development of factor VIII inhibitors in hemophilia A patients. Understanding these risk factors will help to determine future differential treatment in the control and prevention of the development of inhibitors.

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“…Por outro lado, sabe-se que fatores genéticos podem influenciar a frequência e a gravidade da mucosite oral. Alguns estudos demonstraram importante associação entre polimorfismos em genes de citocinas e complicações relacionadas ao TCTH, incluindo a DECH e menor tempo de sobrevida (Sonis, 1998;MacMillan et al, 2003;Dickinson et al, 2007;Visentainer et al, 2008).…”

Section: Discussionunclassified

“…Os polimorfismos em regiões promotoras dos genes das interleucinas podem causar diferenças interindividuais na produção dessas substâncias (Wilson et al, 1997;Pravica et al, 1999;Visentainer et al, 2008). Um grande número de polimorfismos gênicos tem sido identificado nos genes das citocinas, sendo que vários estudos demonstram associação destes polimorfismos com um efeito protetor ou uma maior predisposição ao desenvolvimento de doenças (Tolusso et al, 2006;Sáenz-López et al, 2008;Guerreiro et al, 2009).…”

Section: Citocinas E Polimorfismos Gênicosunclassified

“…Contudo, esse trabalho foi realizado em pacientes com tumores sólidos e, consequentemente, com esquemas terapêuticos distintos daqueles utilizados no TCTH. Os polimorfismos nos genes de citocinas também têm sido associados com outras complicações pós-TCTH, como a doença do enxerto contra o hospedeiro (DECH), recidiva da doença de base e aumento na mortalidade (Ishikawa et al, 2002;MacMillan et al, 2003;Visentainer et al, 2008).…”

Section: Introductionunclassified

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Influencia dos polimorfismos dos genes IL1B-511C/T, IL1B+3953C/T, IL1RN VNTR, TNF-308G/A e IL6-174G/C na mucosite oral apos transplante de celulas-tronco hematopoeticas

Kellermann¹,

Jorge²

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Importância de polimorfismos de genes reguladores de citocinas em transplantes de células progenitoras hematopoiéticas

Cited by 4 publications

References 68 publications

Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation

Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation

Importance of immune response genes in hemophilia A

Influencia dos polimorfismos dos genes IL1B-511C/T, IL1B+3953C/T, IL1RN VNTR, TNF-308G/A e IL6-174G/C na mucosite oral apos transplante de celulas-tronco hematopoeticas

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