Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate

Yener, Gülgün

doi:10.1016/s0378-5173(03)00203-5

Cited by 62 publications

(57 citation statements)

References 7 publications

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“…M samples (0.1 g) with or without DS were placed on a gauze dressing (1Â1 cm 2 ) and then applied directly onto the skin of inner arms, fixed with stretch adhesive tape. There was at least 1-cm distance between 23 For control, the skin of inner arms was also measured before application of the formulations.…”

Section: Skin Irritation Studymentioning

confidence: 99%

Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies

Kantarcı¹,

Özgüney²,

Karasulu³

et al. 2007

AAPS PharmSciTech

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The aim of the present study was to make a comparison of the in vitro release rate of diclofenac sodium (DS) from microemulsion (M) vehicles containing soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols (ethanol [E], isopropyl alcohol [I], and propanol [P]) as cosurfactant. The optimum surfactant:cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of phase diagrams. Three microemulsion formulations were selected, and their physicochemical properties were examined for the pH, viscosity, and conductivity. According to the release rate of DS, M prepared with P showed the significantly highest flux value (0.059 ± 0.018 mg/cm 2 /h) among all formulations (P G .05). The conductivity results showed that DS-loaded microemulsions have higher conductivity values (18.8-20.2 microsiemens/cm) than unloaded formulations (16.9-17.9 microsiemens/cm), and loading DS into the formulation had no negative effect on system stability. Moreover, viscosity measurements were examined as a function of shear rate, and Newtonian fluid characterization was observed for each microemulsion system. All formulations had appropriate observed pH values varying from 6.70 to 6.85 for topical application. A skin irritation study was performed with microemulsions on human volunteers, and no visible reaction was observed with any of the formulations. In conclusion, M prepared with P may be a more appropriate formulation than the other 2 formulations studied as drug carrier for topical application.

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Section: Skin Irritation Studymentioning

confidence: 99%

Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies

Kantarcı¹,

Özgüney²,

Karasulu³

et al. 2007

AAPS PharmSciTech

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“…Yener et al [22] prepared solid lipid microspheres (SLM) of octylmethoxycinnamate (OMC) to achieve controlled release penetration of OMC from skin and to improve its photo stability. The rate of penetration was found to be significantly dependent upon the formulation and could be decreased by up to 77% in SLM formulations.…”

Section: Microparticlesmentioning

confidence: 99%

Multiparticulate carriers for sun‐screening agents

Jain

2010

Intern J of Cosmetic Sci

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SynopsisMany molecular sunscreens penetrate into the skin causing photo-allergic and photo-toxic reactions as well as skin irritations establishing an urgent need for the development of a safer sunscreen formulation. The search for active substances, efficient combinations, and the design of novel vehicles or carriers has led to the implementation of new cosmetic systems in contrast to the classic forms such as creams or gels. Amongst various approaches utilized to improve performance of sunscreening agents, the use of multiparticulate delivery systems is gaining increasing attention amongst researchers. Multiparticulate delivery systems can be incorporated into gels, creams, liquids, powders or other formulations, and can release active agents depending on their temperature, moisture, friction, volatility of the entrapped ingredients or time. These systems also have the ability of scattering or reflecting incoming UV radiations and therefore can act as physical sunscreens on their own. Ré suméBeaucoup de filtres solaires pénètrent à l'état moléculaire dans la peau provoquant des réactions photo-allergiques et photo-toxiques ainsi que des irritations ce qui nécessite un développement urgent de formulation solaire plus sû re. La recherche de substances actives, des mélanges efficaces et la conception de nouveaux véhicules ou de transporteurs a abouti à la mise en oeuvre de nouveaux systèmes cosmétiques face aux formules classiques que sont des crèmes ou des gels. Parmi ces diverses approches utilisées pour améliorer la performance des filtres solaires, l'utilisation de systèmes multi particulaires de délivrance suscite un intérêt croissant parmi les chercheurs. Ces systè-mes multi particulaires peuvent être incorporés à des gels, des crèmes, des liquides, des poudres ou d'autres formulations et peuvent libérer des agents actifs en fonction du temps, ou selon la tempéra-ture, l'humidité, la friction, ou la volatilité des ingrédients encapsulés. Ces systèmes ont aussi la capacité de disperser ou de refléter les radiations UV et peuvent donc agir à eux seuls comme des filtres solaires physiques.

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“…Recently, attention has been focused on lipid microparticles (LMs) as a promising carrier system for sunscreen agents (19,21,22). They consist of a solid lipid core based on naturally occurring lipids and stabilized by a layer of surfactant molecules on the surface (23).…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, their components are physiologically compatible and biodegradable, providing excellent in vivo tolerability (24). Additional advantages of LMs include high loading capacity for lipophilic substances, such as most of the UV filters, and decreased skin penetration of encapsulated sunscreens (21). Moreover, their solid matrix protects incorporated actives against decomposition (24,25).…”

Section: Introductionmentioning

confidence: 99%

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Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

Scalia

Mezzena

2009

AAPS PharmSciTech

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Abstract. The aim of this study was to reduce the photoinstability of butyl methoxydibenzoylmethane (BMDBM), the most widely used UVA filter, by incorporating it in lipid microparticles (LMs) alone or together with the UVB filter octocrylene (OCR), acting also as photostabilizer. Microparticles loaded with BMDBM or with combined BMDBM and OCR were produced by the hot emulsion technique, using glyceryl behenate as lipid material and poloxamer 188 as surfactant. The LMs were characterized by release studies, scanning electron microscopy, and powder X-ray diffractometry. The BMDBM and OCR loading was 15.2% and 10.6%, respectively. In order to reproduce the conditions prevalent in commercial sunscreen products, the photoprotective efficacy of the LMs was evaluated after their introduction in a model cream (oil-in-water emulsion) containing a mixture of UVA and UVB filters. A small but statistically significant decrease in BMDBM photodegradation was obtained when the UVA filter was encapsulated alone into the LMs (the extent of degradation was 28.6% ±2.4 for nonencapsulated BMDBM and 26.0% ±2.5 for BMDBM-loaded microparticles). On the other hand, the coloading of OCR in the LMs produced a more marked reduction in the light-induced decomposition of microencapsulated BMDBM (the UVA filter loss was 21.5% ±2.2). Therefore, incorporation in lipid microparticles of BMDBM together with the sunscreen OCR is more effective in enhancing the UVA filter photostability than LMs loaded with BMDBM alone.

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Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate

Cited by 62 publications

References 7 publications

Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies

Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies

Multiparticulate carriers for sun‐screening agents

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

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