Stellenwert der Kipptischuntersuchung im Vergleich zum Schellong-Test bei orthostaseinduzierten Kreislaufdysregulationen/Synkopen

Jungblut, Sven; Frickmann, Hagen; Römer, Albrecht; Gilfrich, H. J.

doi:10.1007/s00063-006-1024-x

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…In contrast, Werner et al [11] identified a significant association between increased numbers of BM-CPCs and a decreased risk of major cardiovascular events and hospitalization in patients with coronary artery disease. BM-CPCs mobilization can also predict severe endothelial dysfunction in patients with coronary heart disease [36]. Moreover, the transient increase in CD34/45 + and CD133/45 + BM-CPCs reached a maximum after three weeks of regular symptom-limited (ischemic and/or subischemic) exercise training, but did not persist until 3 months after the regular training after acute myocardial infarction [37,38].…”

Section: Discussionmentioning

confidence: 99%

Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes

Bozdağ-Turan

Turan

et al. 2011

Cardiovasc Diabetol

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BackgroundBone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and mobilization. However, it is unknown whether the mobilization of BM-CPCs depends on the number of diseased coronary arteries. Therefore, in our study, we analysed the correlation between the diseased coronary arteries and the frequency of CD34/45+ BM-CPCs in peripheral blood (PB) in patients with ischemic heart disease (IHD).MethodsThe frequency of CD34/45+ BM-CPCs was measured by flow cytometry in 120 patients with coronary 1 vessel (IHD1, n = 40), coronary 2 vessel (IHD2, n = 40), coronary 3 vessel disease (IHD3, n = 40) and in a control group of healthy subjects (n = 40). There was no significant difference of the total number of cardiovascular risk factors between IHD groups, beside diabetes mellitus (DM), which was significantly higher in IHD3 group compared to IHD2 and IHD1 groups.ResultsThe frequency of CD34/45+ BM-CPCs was significantly reduced in patients with IHD compared to the control group (CD34/45+; p < 0.001). The frequency of BM-CPCs was impaired in patients with IHD3 compared to IHD1 (CD34/45+; p < 0.001) and to IHD2 (CD34/45+; p = 0.001). But there was no significant difference in frequency of BM-CPCs between the patients with IHD2 and IHD1 (CD34/45+; p = 0.28). In a subgroup we observed a significant negative correlation between levels of hemoglobin AIc (HbAIc) and the frequency of BM-CPCs (CD34/45+; p < 0.001, r = -0.8).ConclusionsThe frequency of CD34/45+ BM-CPCs in PB is impaired in patients with IHD. This impairment may augment with an increased number of diseased coronary arteries. Moreover, the frequency of CD34/45+ BM-CPCs in ischemic tissue is further impaired by diabetes in patients with IHD.

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Section: Discussionmentioning

confidence: 99%

Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes

Bozdağ-Turan

Turan

et al. 2011

Cardiovasc Diabetol

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“…The mean age of the population (± SD) was 53 (±19 years), and the median age was 56. The diagnostic setting was previously described in detail [ 10 ] and is summarized below (Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The tilt could be controlled using an external protractor that was attached to the table. The head-up tilt device was self-designed as described [ 10 ]. Electrocardiographic (ECG) analysis was continuously performed throughout the analysis.…”

Section: Methodsmentioning

confidence: 99%

Syncope as a health risk for soldiers - influence of medical history and clinical findings on the sensitivity of head-up tilt table testing

Gilfrich

Heidelmann²,

Grube³

et al. 2015

Military Med Res

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BackgroundSyncope is a relevant health problem in military environments. Reliable diagnosis is challenging. Tilt table testing is an important tool for syncope diagnosis. The aim of this study was to determine whether signs such as prodromal symptoms, co-morbidity, frequency of syncopal events, body length, body mass index, and electrocardiography abnormalities can be used to predict the success of tilt table testing at diagnosing syncope.MethodsData from 100 patients with histories of syncope or pre-syncope, who were diagnosed using head-up tilt table testing, were retrospectively analyzed in a cross-sectional analysis. The diagnostic procedure was based upon a modified version of the Westminster protocol without any pharmacological provocation.ResultsPatients showing pathological reaction patterns during tilt table testing suffered from prodromal symptoms, such as dizziness and sweating, significantly more often. The patients reported more injuries resulting from syncopal events and more previous syncopal events, and the prevalence of co-morbidity was greater among patients presenting negative findings during tilt testing. An asthenic-leptosomal physique was not confirmed as a risk factor for syncopal events as is the case for idiopathic arterial hypotension. However, patients with pathological reaction patterns during tilt table testing were significantly taller. This finding was detected for both females and males. No significant predictors were found in the electrocardiogram (ECG) patterns of patients showing syncope during tilt table testing.ConclusionsFrequency of prior syncope and prodromal symptoms, and increased body length with an otherwise good state of health influence the predictive value of tilt table testing for syncope diagnosis. In particular, if these factors are present, tilt table testing should be considered part of the diagnostic algorithm for soldiers with recurrent syncope.

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“…Bei Im Vergleich dazu weist die Kipptisch-Untersuchung eine höhere Sensitivität zum Nachweis einer (insbesondere verzögert auftretenden) orthostatischen Dysregulation auf [19]. Weiterhin kann diese die Bestätigung einer vermuteten vasovagalen Reflexsynkope bzw.…”

Section: Elektrophysiologische Untersuchungunclassified

Schwindel aus internistischer Sicht

Emrani¹,

Napp²

2023

Dtsch Med Wochenschr

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Stellenwert der Kipptischuntersuchung im Vergleich zum Schellong-Test bei orthostaseinduzierten Kreislaufdysregulationen/Synkopen

Abstract: Schellong's test is suitable as a diagnostic procedure for orthostatic dysregulation only, and tilt-table testing is highly superior for objectification of the diagnosis and differentiation of syncope.

Cited by 7 publications

References 8 publications

Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes

Relation between the frequency of CD34+ bone marrow derived circulating progenitor cells and the number of diseased coronary arteries in patients with myocardial ischemia and diabetes

Syncope as a health risk for soldiers - influence of medical history and clinical findings on the sensitivity of head-up tilt table testing

Schwindel aus internistischer Sicht

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