Importance of three-dimensional speckle tracking in the assessment of left atrial and ventricular dysfunction in patients with myotonic dystrophy type 1

Guedes, Henrique; Moreno, Nuno; Santos, Rui Pontes dos; Marqués, L. Pons; Seabra, Daniel; Pereira, Adriana; Andrade, Aurora; Pinto, Paula

doi:10.1016/j.repc.2017.10.011

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Twenty-four studies assessed the cardiac muscle strength indirectly [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][104][105][106]112,113].…”

Section: Cardiac Muscle Strengthmentioning

confidence: 99%

“…Twenty-two studies used echocardiography [34][35][36][37][39][40][41][42][43][44][45][46][47][48][49][50][51][52]105,106,112,113] and three used cardiac magnetic resonance [38,104,106] for the indirect evaluation of cardiac muscle strength. Main findings of the measures used to assess cardiac muscle strength for each study can be found in table 1 and Figure 2A.…”

Section: Cardiac Muscle Strengthmentioning

confidence: 99%

“…Left ventricular ejection fraction (n=21) [34][35][36][37][39][40][41][42][43][44][45][46][47][49][50][51][52]105,106,112,113], left ventricular shortening fraction (n=4) [39,46,51,52], left ventricular global longitudinal strain (n=3) [43,44,106], endocardial shortening fraction (n=2) [47,48] and stroke volume (n=1) [46] were evaluated (table 1). The range of left ventricular ejection fraction values obtained was 56%-70% for patients with DM1 and 61%-77% for controls [34][35][36][37][39][40][41][42][43][44][45][46][47][49][50][51]…”

Section: Echocardiographymentioning

confidence: 99%

See 2 more Smart Citations

Outcome measures frequently used to assess muscle strength in patients with myotonic dystrophy type 1: a systematic review

Mateus

Costa

Viegas

et al. 2022

Neuromuscular Disorders

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“…Twenty-four studies assessed the cardiac muscle strength indirectly [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][104][105][106]112,113].…”

Section: Cardiac Muscle Strengthmentioning

confidence: 99%

Section: Cardiac Muscle Strengthmentioning

confidence: 99%

Section: Echocardiographymentioning

confidence: 99%

See 1 more Smart Citation

Outcome measures frequently used to assess muscle strength in patients with myotonic dystrophy type 1: a systematic review

Mateus

Costa

Viegas

et al. 2022

Neuromuscular Disorders

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“…Cardiac dysfunction is the second common cause of death, about 30% of mortality in adults with DM1. Cardiac involvement in DM1 includes conduction disease, atrial and ventricular tachyarrhythmias, atrioventricular block, left-ventricular systolic dysfunction, and myocardial fibrosis resulting in sudden death (Table 1) [31][32][33].…”

Section: Physiological and Systemic Features Of Dm1mentioning

confidence: 99%

Metabolic Alterations in Myotonic Dystrophy Type 1 and Their Correlation with Lipin

Mateus

Martins

Nunes

et al. 2021

IJERPH

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Myotonic dystrophy type 1 (DM1) is an autosomal dominant hereditary and multisystemic disease, characterized by progressive distal muscle weakness and myotonia. Despite huge efforts, the pathophysiological mechanisms underlying DM1 remain elusive. In this review, the metabolic alterations observed in patients with DM1 and their connection with lipin proteins are discussed. We start by briefly describing the epidemiology, the physiopathological and systemic features of DM1. The molecular mechanisms proposed for DM1 are explored and summarized. An overview of metabolic syndrome, dyslipidemia, and the summary of metabolic alterations observed in patients with DM1 are presented. Patients with DM1 present clinical evidence of metabolic alterations, namely increased levels of triacylglycerol and low-density lipoprotein, increased insulin and glucose levels, increased abdominal obesity, and low levels of high-density lipoprotein. These metabolic alterations may be associated with lipins, which are phosphatidate phosphatase enzymes that regulates the triacylglycerol levels, phospholipids, lipid signaling pathways, and are transcriptional co-activators. Furthermore, lipins are also important for autophagy, inflammasome activation and lipoproteins synthesis. We demonstrate the association of lipin with the metabolic alterations in patients with DM1, which supports further clinical studies and a proper exploration of lipin proteins as therapeutic targets for metabolic syndrome, which is important for controlling many diseases including DM1.

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“…3D‐STE can also detect early left ventricular dysfunction caused by hypertrophic cardiomyopathy, essential hypertension, type 2 diabetes mellitus, and chemotherapy drugs . In addition to evaluating LV myocardial motion, 3D‐STE can also evaluate the left atrium, right atrium, and right ventricle …”

Section: D‐ste In Assessing Myocardial Motionmentioning

confidence: 99%

Three‐dimensional speckle‐tracking echocardiography for evaluating myocardial motion in patients with cardiorenal syndrome

Zhang

Qiu

Chen

et al. 2019

J of Clinical Ultrasound

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Because of better awareness and understanding of its pathophysiology, the cardiorenal syndrome (CRS) is more often diagnosed and better managed. The echocardiographic evaluation of CRS now benefits from three‐dimensional speckle tracking echocardiography (3D‐STE), which allows multidimensional and real‐time evaluation of regional myocardial and overall cardiac function, and helps assessing the degree of myocardial damage. This article describes the application of 3D‐STE in evaluating the myocardial motion in patients with CRS.

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Importance of three-dimensional speckle tracking in the assessment of left atrial and ventricular dysfunction in patients with myotonic dystrophy type 1

Abstract: LA and LV global longitudinal strain is significantly decreased in patients with DM1, which may be an early marker of subclinical dysfunction in these patients.

Cited by 10 publications

References 28 publications

Outcome measures frequently used to assess muscle strength in patients with myotonic dystrophy type 1: a systematic review

Outcome measures frequently used to assess muscle strength in patients with myotonic dystrophy type 1: a systematic review

Metabolic Alterations in Myotonic Dystrophy Type 1 and Their Correlation with Lipin

Three‐dimensional speckle‐tracking echocardiography for evaluating myocardial motion in patients with cardiorenal syndrome

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