Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease

Egroo, Maxime Van; Koshmanova, Ekaterina; Vandewalle, Gilles; Jacobs, Heidi I.L.

doi:10.1016/j.smrv.2022.101592

Cited by 56 publications

(56 citation statements)

References 118 publications

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“…Further, norepinephrine (NE), which regulates glymphatic function, is also an important factor that affects sleep and migraine. On the one hand, NE regulates the sleep-wake cycle of glymphatic exchange and the volume of extracellular perivascular space ( 80 ). Arousal causes a burst of NE release, which turns the GS off and increases the resistance of fluid transport.…”

Section: Glymphatic System Is a Possible Key In The Bidirectional Rel...mentioning

confidence: 99%

Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

Gao

Zhu

et al. 2022

Front. Neurol.

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Sleep contributes to the maintenance of overall health and well-being. There are a growing number of patients who have headache disorders that are significantly affected by poor sleep. This is a paradoxical relationship, whereby sleep deprivation or excess sleep leads to a worsening of headaches, yet sleep onset also alleviates ongoing headache pain. Currently, the mechanism of action remains controversial and poorly understood. The glymphatic system is a newly discovered perivascular network that encompasses the whole brain and is responsible for removing toxic proteins and waste metabolites from the brain as well as replenishing nutrition and energy. Recent studies have suggested that glymphatic dysfunction is a common underlying etiology of sleep disorders and headache pain. This study reviews the current literature on the relationship between the glymphatic system, sleep, and headaches, discusses their roles, and proposes acupuncture as a non-invasive way to focus on the glymphatic function to improve sleep quality and alleviate headache pain.

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Section: Glymphatic System Is a Possible Key In The Bidirectional Rel...mentioning

confidence: 99%

Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

Gao

Zhu

et al. 2022

Front. Neurol.

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“…However, additional effects, of NA in the regulation of other processes that take place in the CNS have also been described during the last years. NA is a major modulator of behavior controlling different cognitive functions such as attention, motivation, stress, sleep, mood, and memory among others [ 3 , 4 , 5 , 6 ]. NA also modulates neuronal metabolism, synaptic plasticity, glial cells activity, and blood-brain barrier permeability [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Noradrenaline in Alzheimer’s Disease: A New Potential Therapeutic Target

Gutiérrez

Russo

Novellino

et al. 2022

IJMS

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A growing body of evidence demonstrates the important role of the noradrenergic system in the pathogenesis of many neurodegenerative processes, especially Alzheimer’s disease, due to its ability to control glial activation and chemokine production resulting in anti-inflammatory and neuroprotective effects. Noradrenaline involvement in this disease was first proposed after finding deficits of noradrenergic neurons in the locus coeruleus from Alzheimer’s disease patients. Based on this, it has been hypothesized that the early loss of noradrenergic projections and the subsequent reduction of noradrenaline brain levels contribute to cognitive dysfunctions and the progression of neurodegeneration. Several studies have focused on analyzing the role of noradrenaline in the development and progression of Alzheimer’s disease. In this review we summarize some of the most relevant data describing the alterations of the noradrenergic system normally occurring in Alzheimer’s disease as well as experimental studies in which noradrenaline concentration was modified in order to further analyze how these alterations affect the behavior and viability of different nervous cells. The combination of the different studies here presented suggests that the maintenance of adequate noradrenaline levels in the central nervous system constitutes a key factor of the endogenous defense systems that help prevent or delay the development of Alzheimer’s disease. For this reason, the use of noradrenaline modulating drugs is proposed as an interesting alternative therapeutic option for Alzheimer’s disease.

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“…Circadian rhythms and brain waves are in turn involved in sleep-wake processes, which are related to a neural circuitry consisting of the ascending wake-promoting pathway made of projections from various groups of cholinergic, noradrenergic, serotoninergic, dopaminergic, and histaminergic neurons located in the pedunculopontine and laterodorsal tegmental nucleus, locus coeruleus, dorsal and median raphe nucleus, and tuberomammillary nucleus, respectively. 10 , 11 However, every 24 h, the arousal system is inhibited during sleep by sleep-active γ-aminobutyric acid (GABA)-ergic and galaninergic neurons of the ventrolateral preoptic nucleus (VLPO). 10 , 11 The reciprocal inhibitory exchange between the major ascending monoaminergic arousal groups and the sleep-inducing VLPO acts as a feedback loop; when monoamine nuclei discharge intensively during wakefulness, they inhibit the VLPO, and when VLPO fire rapidly during sleep, block the discharge of the monoamine cell groups, functioning like an electrical “on-off” switch, enabling the body to maintain a stable state of wakefulness and sleep.…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 11 However, every 24 h, the arousal system is inhibited during sleep by sleep-active γ-aminobutyric acid (GABA)-ergic and galaninergic neurons of the ventrolateral preoptic nucleus (VLPO). 10 , 11 The reciprocal inhibitory exchange between the major ascending monoaminergic arousal groups and the sleep-inducing VLPO acts as a feedback loop; when monoamine nuclei discharge intensively during wakefulness, they inhibit the VLPO, and when VLPO fire rapidly during sleep, block the discharge of the monoamine cell groups, functioning like an electrical “on-off” switch, enabling the body to maintain a stable state of wakefulness and sleep. 10 , 11 Sleep consists of the alternation of two different physiological and behavioral states, each of them with distinct electrophysiological features: the rapid eye movement (REM) sleep or “cortical activation” and the NREM sleep or “cortical deactivation”.…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 11 The reciprocal inhibitory exchange between the major ascending monoaminergic arousal groups and the sleep-inducing VLPO acts as a feedback loop; when monoamine nuclei discharge intensively during wakefulness, they inhibit the VLPO, and when VLPO fire rapidly during sleep, block the discharge of the monoamine cell groups, functioning like an electrical “on-off” switch, enabling the body to maintain a stable state of wakefulness and sleep. 10 , 11 Sleep consists of the alternation of two different physiological and behavioral states, each of them with distinct electrophysiological features: the rapid eye movement (REM) sleep or “cortical activation” and the NREM sleep or “cortical deactivation”. Specific characteristics of REM/NREM sleep phases depend on the complexity of the CNS; however, there are common shared traits among species, such as specific properties associated with the frequency spectrum of distinct sleep states.…”

Section: Introductionmentioning

confidence: 99%

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In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine

Pavan¹,

Bianchi²,

Botti³

2022

iScience

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Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease

Cited by 56 publications

References 118 publications

Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

Glymphatic System Dysfunction: A Novel Mediator of Sleep Disorders and Headaches

Noradrenaline in Alzheimer’s Disease: A New Potential Therapeutic Target

In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine

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