Importance of the initial response to GPi deep brain stimulation in dystonia: A nine year quality of life study

Quality of life outcomes after deep brain stimulation in dystonia: A systematic review

“…Pain is known to be one of the major determinants of HRQoL [2,74]. Bodily pain of SF-36 showed significant improvement in most studies [4,5,10,31,38,[40][41][42][43]45,47,73], which was consistent with the outcomes assessed with the scales specific to pain problems [5,34,38,39,75,76]. The general health scale of the SF-36 also significantly improved, suggesting that the patients' overall life satisfaction improved after DBS surgery [4,5,31,[41][42][43]45,72].…”

“…Most articles on inherited or idiopathic isolated dystonia patients reported significant improvement in physical QoL (physical functioning, role physical, bodily pain, and general health) [4,5,10,31,36,[40][41][42][43]45,47,72,73]. The physical functioning and role physical domains of SF-36 assess physical disability similar to BFMDRS-D, and TWSTRS disability scores.…”

“…Prospective clinical trials have shown sustained motor and HRQoL improvement for up to 5 years, which will be discussed in the following paragraphs [4,31]. In addition, a few retrospective studies reported favorable motor outcomes beyond 5 years in most cases without showing HRQoL data [10,[32][33][34][35]. T. Tsuboi, et al Parkinsonism and Related Disorders 70 (2020) [82][83][84][85][86][87][88][89][90][91][92][93] In a French prospective, controlled, multicenter study on 22 patients with primary generalized dystonia, BFMDRS-M improved by 51% at 1 year and 58% at 3 years after bilateral GPi DBS [4,36].…”

“…A retrospective study on 16 isolated generalized or segmental dystonia patients treated with GPi DBS showed that a significant improvement was maintained up to ≥9 years only in the role physical domain of SF-36 compared with baseline [10]. Significant improvements in SF-36 Total, PCS, and MCS were found at 1-2 years whereas improvements remained significant at ≥ 9 years only for Total and MCS.…”

“…Recent DBS studies reported HRQoL outcomes citing their increasing importance when investigating the overall efficacy of interventions [10][11][12][13]. Therefore, there is a need for an update on a systematic review of HRQoL outcomes after DBS [14,15].…”