Importance of the glucocorticoid stress response in a changing world: Theory, hypotheses and perspectives

Angelier, Frédéric; Wingfield, John C.

doi:10.1016/j.ygcen.2013.05.022

Cited by 208 publications

(171 citation statements)

References 88 publications

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“…1A), was driven by two snakes with an extreme response in oxygen consumption rate to high temperatures. The importance of individual variation in temperature sensitivity of these physiological traits in shaping the evolution of the stress response to high temperatures represents another important direction for future research (Angelier and Wingfield, 2013;Cockrem, 2013). Surprisingly, the dependence of oxygen consumption rate on ecotype-specific body mass was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

Gangloff

Holden

Telemeco

et al. 2016

Journal of Experimental Biology

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Extreme temperatures constrain organismal physiology and impose both acute and chronic effects. Additionally, temperature-induced hormone-mediated stress response pathways and energetic tradeoffs are important drivers of life-history variation. This study employs an integrative approach to quantify acute physiological responses to high temperatures in divergent life-history ecotypes of the western terrestrial garter snake (Thamnophis elegans). Using wild-caught animals, we measured oxygen consumption rate and physiological markers of hormonal stress response, energy availability and anaerobic respiration in blood plasma across five ecologically relevant temperatures (24, 28, 32, 35 and 38°C; 3 h exposure). Corticosterone, insulin and glucose concentrations all increased with temperature, but with different thermal response curves, suggesting that high temperatures differently affect energy-regulation pathways. Additionally, oxygen consumption rate increased without plateau and lactate concentration did not increase with temperature, challenging the recent hypothesis that oxygen limitation sets upper thermal tolerance limits. Finally, animals had similar physiological thermal responses to high-temperature exposure regardless of genetic background, suggesting that local adaptation has not resulted in fixed differences between ecotypes. Together, these results identify some of the mechanisms by which higher temperatures alter hormonal-mediated energy balance in reptiles and potential limits to the flexibility of this response.

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Section: Discussionmentioning

confidence: 99%

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

Gangloff

Holden

Telemeco

et al. 2016

Journal of Experimental Biology

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“…Activation of the CRH-ACTH-system is manifested by an increase in blood concentration of glucose, resulting from enhanced glycogenolysis and blockade of cellular uptake of this sugar. Moreover, cortisol stimulates lipolysis and degradation of proteins, as well as cleavage of fatty acids to ketone bodies [12][13][14][15].…”

Section: Figure 1 Interaction Between the Nervous And Endocrine Systmentioning

confidence: 99%

“…Stymulacja układu CRH-ACTH-kortyzol manifestuje się wzrostem stężenia glukozy we krwi, spowodowanym nasileniem glikoneogenezy i blokadą wychwytu glukozy przez komórki. Ponadto kortyzol powoduje przyspieszenie lipolizy i degradacji białek oraz rozkład kwasów tłuszczowych do ciał ketonowych [12][13][14][15].…”

Section: Neuroendokrynne Uwarunkowania Reakcji Na Stresunclassified

Czynnościowy podwzgórzowy brak miesiączki – trudności diagnostyczne, monitorowanie i leczenie

Sowińska-Przepiera

Andrysiak‐Mamos

Jarząbek-Bielecka

et al. 2015

Endokrynologia Polska

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Functional hypothalamic amenorrhoea (FHA) is associated with functional inhibition of the hypothalamic-pituitary-ovarian axis. Causes of FHA can be classified into the three groups: 1) stress-related factors, 2) consequences of weight loss and/or underweight, and 3) consequences of physical exercise or practicing sports. Diagnosis of FHA should be based on a history of menstrual disorders. During physical examination, patients with FHA present with secondary and tertiary sex characteristics specific for the pubertal stage preceding development of the condition and with the signs of hypoestrogenism. Laboratory results determine further management of patients with amenorrhea, and thus their correct interpretation is vital for making appropriate therapeutic decisions. Treatment of chronic anovulation, menstrual disorders, and secondary amenorrhea resulting from hypothalamic disorders should be aimed at the elimination of the primary cause, i.e. a decrease in psycho-emotional strain, avoidance of chronic stressors, reduction of physical exercise level, or optimisation of BMI in patients who lose weight. If menses do not resume after a period of six months or primary causative treatment is not possible, neutralisation of hypoestrogenism consequences, especially unfavourable effects on bone metabolism, become the main issue. Previous studies have shown that oestroprogestagen therapy is useful in both the treatment of menstrual disorders and normalisation of bone mineral density. StreszczenieCzynnościowy brak miesiączki pochodzenia podwzgórzowego (FHA) polega na zahamowaniu czynności osi podwzgórze-przysadka-jajniki. Przyczyny FHA można podzielić na trzy grupy: 1) czynniki związane ze stresem, 2) następstwa utraty masy ciała i/lub występowania niskiej masy ciała, oraz 3) konsekwencje wysiłku fizycznego lub uprawiania sportu. Dla rozpoznania FHA istotne są dane z wywiadu na temat występowania zaburzeń cykli miesiączkowych. W badaniu fizykalnym pacjentek z FHA stwierdza się występowanie drugoi trzeciorzędowych cech płciowych zależnie od stadium zaawansowania pokwitania przed wystąpieniem schorzenia oraz objawy hipoestrogenizmu. Wyniki badań laboratoryjnych dostarczają informacji, na podstawie których decyduje się o sposobie leczenia, a ich właściwa interpretacja ma kluczowe znaczenie w podejmowaniu właściwych decyzji terapeutycznych. Leczenie przewlekłego braku jajeczkowania, zaburzeń cyklu miesiączkowego i wtórnego braku miesiączki wynikającego z zaburzeń podwzgórzowych powinno być ukierunkowane na usunięcie pierwotnej przyczyny, czyli obniżenie napięcia psychoemocjonalnego, unikanie czynników wywołujących przewlekły stres, zmniejszenie wysiłku fizycznego i poprawę wskaźnika masy ciała u odchudzających się pacjentek. Jeśli miesiączkowanie nie występuje przez okres ponad 6 miesięcy lub gdy pierwotne leczenie przyczynowe nie jest możliwe, głównym problemem terapeutycznym staje się neutralizacja następstw hipoestrogenizmu, a zwłaszcza jego niekorzystnego wpływu na metabolizm kostny. W dotychczasowych badaniach wyk...

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“…Allostasis integrates an organism's functional responses to predictable and/or unpredictable environmental conditions (Angelier and Wingfield, 2013;Landys et al, 2006;Wingfield, 2003, 2010;Romero et al, 2009). In vertebrates, glucocorticoids (GCs) constitute the main mediators of allostasis because they are released in response to both natural physiological demands and unpredictable events (i.e.…”

Section: Introductionmentioning

confidence: 99%

Water deprivation increases maternal corticosterone levels and enhances offspring growth in the snake Vipera aspis

Dupoué

Angelier

Brischoux

et al. 2016

Journal of Experimental Biology

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Circulating glucocorticoid (GC) levels may increase as a result of reproductive effort or in response to unpredictable events. However, GC secretion can vary with the availability of vital trophic resources such as energy. While water represents another critical resource, the impact of water deprivation on GC secretion during reproduction has not yet been thoroughly investigated. Here, we examined the effects of water deprivation on plasma corticosterone (CORT) concentrations of female aspic vipers (Vipera aspis), and determined the impacts of water deprivation on offspring traits. We exposed both pregnant and non-reproductive females to a 20-day water deprivation and compared their pre-and post-deprivation CORT levels with those of control females. At the end of the treatment, only water-deprived pregnant females showed a significant increase in CORT levels. In pregnant females, changes in baseline CORT level were correlated with changes in female hydration state. Changes in baseline CORT levels were also negatively influenced by maternal reproductive effort in pregnant control females, while such a relationship was not apparent in pregnant water-deprived females. Finally, we found that offspring from water-deprived females had higher growth rates than offspring from control females. Offspring growth was also positively correlated with changes in both maternal osmolality and baseline CORT levels. Together, our results suggest that dehydration increases maternal CORT levels, which may subsequently influence offspring development. Further long-term field studies are therefore required to assess whether there is an adaptive significance of this response.

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Importance of the glucocorticoid stress response in a changing world: Theory, hypotheses and perspectives

Cited by 208 publications

References 88 publications

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

Hormonal and metabolic responses to upper temperature extremes in divergent life-history ecotypes of a garter snake

Czynnościowy podwzgórzowy brak miesiączki – trudności diagnostyczne, monitorowanie i leczenie

Water deprivation increases maternal corticosterone levels and enhances offspring growth in the snake Vipera aspis

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