Importance of spinal deformity index in risk evaluation of VCF (vertebral compression fractures) in obese subjects: prospective study

Ruosi, Carlo; Liccardo, S.; Rossi, D.; Colella, G; Somma, Carolina Di; Colao, Annamaria

doi:10.1007/s00586-013-3009-9

Cited by 15 publications

(12 citation statements)

References 19 publications

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“…In agreement with previous reports [26], we observed hypovitaminosis D in 72% of SCD patients. Regarding 2009, we had data available for only 12 patients, 5 (41.6%) of which had values compatible with a deficiency condition (<10 ng/mL), while 7 (58.3%) presented levels within the insufficiency range (<30 ng/mL).…”

Section: Biochemical Evaluationssupporting

confidence: 93%

Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

Franceschi

Gabbiani

Giusti³

et al. 2020

JCM

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Sickle-cell disease (SCD) is a worldwide distributed hemoglobinopathy, characterized by hemolytic anemia associated with vaso-occlusive events. These result in acute and chronic multiorgan damage. Bone is early involved, leading to long-term disability, chronic pain and fractures. Here, we carried out a retrospective study to evaluate sickle bone disease (SBD) in a cohort of adults with SCD. We assessed bone density, metabolism and turnover. We also evaluated the presence of fractures and the correlation between SCD severity and skeletal manifestations. A total of 71 patients with SCD were analyzed. The mean age of population was 39 ± 10 years, 56% of which were females. We found osteoporosis in a range between 7% and 18% with a high incidence of vertebral fractures. LDH and AST were predictive for the severity of vertebral fractures, while bone density was not. Noteworthy, we identified -1.4 Standard Deviations T-score as the cutoff for detecting the presence of fractures in patients with SCD. Collectively our data allowed us to develop an algorithm for the management of SBD, which may be useful in daily clinical practice to early intersect and treat SBD.

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Section: Biochemical Evaluationssupporting

confidence: 93%

Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

Franceschi

Gabbiani

Giusti³

et al. 2020

JCM

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“…Subsequently for each subject the SDI was calculated by summing the SQ grade for each of the 13 vertebrae from T4 to L4. In a prospective study on 54 obese subjects (51 ± 16 years, 10 males, 44 females), SDI was found to be an useful index of vertebral fractures risk, as it has been demonstrated in postmenopausal osteoporotic females (10).…”

Section: Obesitymentioning

confidence: 90%

“…DXA essentially focuses on the mineralised component, and it is still the most widely used tool to assess BMD to estimate the bone fragility fracture risk. In a study on obese patients, more than 50% of subjects, with at least one vertebral fracture, exhibited a normal or only slightly reduced BMD, but not osteoporosis, and vertebral fractures occurred 4.4-fold more frequently in patients than controls, thus suggesting that in obese population DXA may not represent an accurate instrument to adequately estimate the fracture risk (10). Data on the risk of hip fractures in obese patients are not conclusive even for the influence of diabetes (11).…”

Section: Obesitymentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders

Eller-Vainicher

Falchetti

Gennari

et al. 2019

European Journal of Endocrinology

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An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrine-related forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinical practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone quality in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patients with endocrine diseases are reported.

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“…(6) However, adipose tissue may have negative effects on bone metabolism. (6) A number of previous studies have shown that fat mass was associated with a decrease of bone mass and bone quality at spine, (7)(8)(9) leading to lower vertebral bone strength. The interaction of the different effects of mechanical loading and adiposity is still unclear.…”

Section: Introductionmentioning

confidence: 99%

How Does Obesity Influence the Risk of Vertebral Fracture? Findings From the UK Biobank Participants

Luo

Lee

2020

JBMR Plus

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Obesity and osteoporotic-related fractures are two common public health problems, although it is unclear how obesity affects the risk of vertebral fractures. The purpose of this study was to examine the association between different measures of obesity and the risk of vertebral fracture, and to establish the various clinical factors that can predict such risk. We analyzed data obtained from 502,543 participants in the UK Biobank (229,138 men and 273,405 women), aged 40 to 69 years. Imaging information was available in a subset of this cohort (5189 participants: 2473 men and 2716 women). We further examined how BMD and geometry of the vertebrae were related to body fat measures. It was shown that a larger waist circumference (WC), but not BMI, was associated with an increase in fracture risk in men, but in women, neither BMI nor WC affected the risk. Trunk fat mass, visceral adipose tissue (VAT) mass, and limb fat mass were negatively associated with vertebral body BMD and geometry in men and women. BMD and geometry are related to vertebral strength, but may not be directly related to the risk of fractures, which is also influenced by other factors. The binary logistic regression equation established in this study may be useful to clinicians for the prediction of vertebral fracture risks, and may provide further information to supplement the fracture risk assessment tool, which assesses general fracture risks.

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Importance of spinal deformity index in risk evaluation of VCF (vertebral compression fractures) in obese subjects: prospective study

Cited by 15 publications

References 19 publications

Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up

DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders

How Does Obesity Influence the Risk of Vertebral Fracture? Findings From the UK Biobank Participants

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