Importance of RDW value in differential diagnosis of hypochrome anemias

Abstract

Red cell distribution width (RDW) was studied in adults carrying d-b thalassemia traits (db-TT) who were 20±40 years of age (n = 29), b thalassemia traits (b-TT) with an age range of 18±60 years (n = 49), iron de®ciency anemia (IDA) in individuals aged 1±18 years (n = 27), and in controls with an age range of 20±40 years (n = 20). Although red blood cell count, MCV, and MCH values showed no statistically signi®cant differences between db-TT and b-TT, the mean RDW value was signi®cantly higher in db-TT (20.14 1.21) compared to b-TT (14.88 1.77) (P < 0.001). No difference was observed between the means of RDW in db-TT and IDA (18.00 1.94) (P > 0.05). A signi®cant rise in RDW in IDA 5±7 days after initiation of iron therapy (P = 0.00) which was continued to rise up to the 4 th week of therapy was suggested as an important tool in differentiation of IDA from db-TT. These observations could be kept in mind in the differential diagnosis of db-TT from b-TT and IDA by determining the red blood cell count, red cell indices, and RDW only. Am.

New predictor of acute necrotizing pancreatitis: Red cell distribution width

“…RDW values are increased in hemolytic anemia, in the case of erythrocyte transfusion, and deficiency of vitamin B 12 , folic acid and iron. 9,11,12 Many studies have shown a correlation between higher RDW values and prognosis, but these studies were about cardiovascular and cerebrovascular diseases, chronic renal failure, liver disease, pancreatitis and venous thromboembolism. [13][14][15][16][17] Kurt et al showed a correlation of nonvalvular atrial fibrillation and higher RDW values in 320 patients.…”

Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition?

“…35 In our study, all hematological indexes of the MA and A groups became similar to controls at the end of three-month iron treatment, except the persistently higher RDW value. As we can't definitely explain the reason of elevated RDW values at the end of the followup, we believe that probably longer time than previously reported is needed for normalization of RDW.…”

¿Puede usarse el receptor soluble de transferrina para diagnosticar anemia ferropénica y evaluar la respuesta al hierro en lactantes con desnutrición aguda moderada?

“…35 En nuestro estudio, todos los índices hematológicos de los grupos DA y A alcanzaron valores similares a los de los controles al final de los tres meses de tratamiento con hierro, excepto el valor persistentemente elevado de ADE. Dado que no es posible explicar decididamente el motivo de los valores elevados de ADE al final de estudio, consideramos que es posible que se necesite un período más prolongado que el informado previamente para lograr la normalización de la ADE.…”