Importance of mitral regurgitation inpatients undergoing percutaneous coronaryintervention for acute myocardial infarction

Pellizzon, Gregory G.; Grines, Cindy L.; Cox, David A.; Stuckey, Thomas; Tcheng, James E.; Garcı́a, Eulogio; Guagliumi, Giulio; Turco, Mark; Lansky, Alexandra J.; Griffin, John J.; Cohen, David J.; Aymong, Eve; Mehran, Roxana; O’Neill, William W.; Stone, Gregg W.

doi:10.1016/j.jacc.2003.11.046

Cited by 84 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, hemodynamic parameters were not different between the two groups. In accordance with previous studies [1, 2, 4], MR was more commonly observed in older patients than in younger patients. Although the presence of more severe coronary artery disease and degeneration of the mitral valve with aging may be plausible mechanisms for the higher incidence of MR in older patients, the incidence of multivessel disease was comparable between patients with and without MR.…”

Section: Discussionsupporting

confidence: 92%

“…Although most MR after AMI is mild and rarely causes hemodynamic compromise, the presence of mild MR during the early phase of AMI is an independent predictor of long-term cardiovascular mortality [1,2,3,4]. Despite the importance of MR in the long-term prognosis, the process by which MR increases mortality remains to be elucidated, and there have only been a few reports regarding early predictors of MR after anterior AMI [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Kohno

Anzai²,

Naito³

et al. 2007

Cardiology

View full text Add to dashboard Cite

Background/Aims: Mitral regurgitation (MR) is frequently observed in patients with acute myocardial infarction (AMI), and is known to convey an adverse prognosis. We sought to clarify the relationship between MR and left ventricular (LV) remodeling, in association with serum C-reactive protein (CRP) elevation. Methods/Results: A total of 181 patients with first anterior ST-elevation AMI were examined. MR was detected in 68 patients by color Doppler echocardiography 2 weeks after AMI, and the patients with MR were associated with higher incidence of readmission for heart failure. Serum CRP was serially measured, and the peak serum CRP level was markedly increased in patients with MR compared with those without MR. Multiple logistic regression analysis showed that peak CRP tertile was an independent determinant of MR after AMI (p < 0.0001). In the substudy, the increases in LV end-diastolic volume and sphericity index were higher in patients with MR than in those without MR. Conclusions: MR during the early phase of anterior AMI was associated with LV spherical change and late-phase heart failure, in association with increased serum CRP level. These findings suggest an important role of the inflammatory response in the development of ischemic MR and LV remodeling.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Kohno

Anzai²,

Naito³

et al. 2007

Cardiology

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] Although increasing IMR severity has been shown to be significantly associated with increasing mortality, 2 significant left ventricular (LV) dilation, systolic dysfunction, and myocardial scar burden likely contribute to the progression of IMR, and they have also been shown to be powerful imaging predictors of adverse events in patients with ischemic cardiomyopathy (ICM). [5][6][7][8][9][10] IMR may become more severe with adverse remodeling during followup, and as a result, further adverse remodeling likely ensues.…”

mentioning

confidence: 99%

Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy

Kwon

Kusunose

Obuchowski

et al. 2016

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

This was an observational cohort study of 336 consecutive patients with the diagnosis of ICM (≥70% stenosis in ≥1 epicardial coronary Background-Ischemic mitral regurgitation (IMR) is associated with poor outcomes. It is unknown what factors contribute to progression of IMR and how progressive IMR affects outcomes. We sought to determine imaging predictors of IMR progression and to determine if progressive IMR is an independent predictor of survival in patients with advanced ischemic cardiomyopathy. Methods and Results-Consecutive advanced ischemic cardiomyopathy patients who underwent cardiac magnetic resonance and echocardiograms at baseline with echocardiographic follow-up were studied. Cardiac magnetic resonance was used to assess left ventricular volumes, infarct size, and mitral valve geometry. The effective regurgitant orifice area (EROA) was calculated from the proximal isovelocity surface area by echocardiography. Repeated measures mixed effects and Cox proportional hazards regression models were built to identify predictors of IMR progression and survival. We evaluated 336 patients (age, 62±11 years) over a median follow-up time of 54 months: 154 patients were subsequently revascularized, and 182 patients were medically treated. Ninety-eight patients (29%) demonstrated an increase in EROA values of ≥0.1 cm 2 . There were 87 adverse events (death or transplant). On multivariable analysis, infarct size (P<0.001), progression in IMR (P=0.008), age (P=0.003), and baseline EROA (P=0.010) were independently associated with adverse events. Independent predictors of IMR progression were as follows: baseline EROA (P<0.001), left ventricular end-systolic volume index (P=0.014), and total scar (P=0.036). Conclusions-IMR frequently increases in severity, and progression is independently associated with adverse left ventricular remodeling and infarct size, as assessed by cardiac magnetic resonance. Furthermore, IMR progression is a powerful independent predictor of adverse events, even after controlling for the severity of IMR at baseline. (Circ Cardiovasc Imaging. 2016;9:e004577.

show abstract

“…Risk of death was directly related to the importance of IMR (3). In patients undergoing primary PCI in the setup of an acute MI (16), Pellizzony et al (17) showed that survival was markedly reduced in patients with IMR at both 30 days and one year, and was correlated with the severity of mitral regurgitation. Even the …”

Section: Discussionmentioning

confidence: 99%

Long-term influence of mild or moderate ischemic mitral regurgitation after off-pump coronary artery bypass surgery

Hong

Cartier

Pellerin

et al. 2010

Canadian Journal of Cardiology

View full text Add to dashboard Cite

Importance of mitral regurgitation inpatients undergoing percutaneous coronaryintervention for acute myocardial infarction

Cited by 84 publications

References 36 publications

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Impact of Serum C-Reactive Protein Elevation on the Left Ventricular Spherical Change and the Development of Mitral Regurgitation after Anterior Acute Myocardial Infarction

Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy

Long-term influence of mild or moderate ischemic mitral regurgitation after off-pump coronary artery bypass surgery

Contact Info

Product

Resources

About