Importance of mean platelet volume in patients with chronic obstructive pulmonary disease

Abstract

Chronic obstructive pulmonary disease (COPD) is an important public health problem and it is associated with systemic inflammation. Mean platelet volume (MPV) is one of the markers indicating platelet activation, and there are different results in different diseases related to inflammation. As for COPD some studies found it to be high whereas others found low results. In this study, we aimed to study parameters like MPV, platelet distribution volume (PDW), red blood cell (RBC), which are studied in the complete blood count testing routinely of patients with COPD, smoking and nonsmoking subjects without chronic diseases. Data of 121 patients with COPD, 101 nonsmoking subjects and 102 smoking subjects were retrospectively enrolled. Results were statistically analyzed. MPV levels were lower in patients with COPD compared with smokers (P<0.001) and nonsmoking subjects (P<0.001) but platelet levels were not significantly different. PDW levels found to be lower in COPD group compared with smokers (P<0.013) and nonsmokers (P<0.001). White blood cells were higher in patients with COPD as were expected (P<0.001). Neutrophil levels also were higher in patients with COPD compared with smokers (P<0.003) and nonsmokers (P<0.0001). RBC levels were lower in patients with COPD when compared with nonsmokers (P<0.001). The results of this study suggest that the decreased MPV and PDW may be used as negative reactants for evaluation of COPD.

Platelet indices in stable chronic obstructive pulmonary disease – association with inflammatory markers, comorbidities and therapy

“…Chronic obstructive pulmonary disease patients had lower MPV during an exacerbation episode, and the level increased after the recovery period ( 12 ). Accordingly, following up the MPV levels could be used for monitoring the recovery after the exacerbation ( 7 ). Beside a lower MPV in acute exacerbation, a decrease in MPV was also found before in stable phase of COPD when compared to control group ( 12 ).…”

“…Mean platelet volume and PDW are considered the markers for platelet activation that are commonly increased in patients with thrombotic and atherogenic risk ( 6 , 11 ). However, in COPD patients, beside an increase, a decrease in MPV was also reported due to the burden of inflammation presentable as exacerbation, intensive degradation of platelets or utilization of larger platelets at site of inflammation during the intercellular reactions ( 7 , 10 , 12 , 13 ). Platelet distribution width gives information about diversity of platelet size, so there is an increase in PDW in case of platelet hyperproduction, which cause the release of immature larger platelets from bone marrow ( 14 ).…”

Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi

“…Makhlouf et al [25] reported that PDW, PCT, and CRP were significantly higher in COPD patients, either nondiabetic or diabetic. Koc et al [35] found that MPV and PDW levels were lower, and WBC was higher in patients with COPD compared to smokers and nonsmoking subjects; however, the platelet count was not significantly different.…”

Bronşektazili Hastalarda Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliğinin Değerlendirilmesi

“…Yakın zamanda KOAH'lı hastalar üzerinde yaptığımız bir çalışmada MPV değerlerinin KOAH'ta sigara içen ve içmeyen bireylere göre daha düşük olduğu saptandı. 13 Benzer şekilde Bansal ve ark.nın 100 KOAH'lı ve 100 sağlıklı birey üzerinde yaptıkları bir çalışmada KOAH'lı hastalarda MPV değerlerinin kontrol gruplarına göre daha yüksek olduğu saptanmıştır. 14 Yine Ulaşlı ve ark.nın KOAH'lı hastalar üzerinde yaptıkları bir çalışmada özellikle alevlenme dönemlerinde MPV değerlerinde düşme olduğu saptanmıştır.…”