Importance of Lymph Node Dissection in Thymic Carcinoma

Park, In Kyu; Kim, Young Tae; Jeon, Jae Hyun; Kim, Hye Seon; Hwang, Yoohwa; Seong, Yong Won; Kang, Chang Hyun; Kim, Joo Hyun

doi:10.1016/j.athoracsur.2013.04.057

Cited by 37 publications

(34 citation statements)

References 26 publications

(40 reference statements)

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“…Park et al reviewed the lymph node status in 37 patients with thymic carcinoma and showed that lymph node metastasis was a poor prognostic factor. Care should be taken when determining lymph node dissection, and to accurately predict prognosis, dissection of more than 10 lymph nodes is required [26].…”

Section: Discussionmentioning

confidence: 99%

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Zhang

et al. 2015

Int J Clin Oncol

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Masaoka stage (P = 0.048), and higher complete resection rates (P = 0.042). However, multivariate analysis demonstrated that complete resection was the only independent predictor for overall survival (OS) (P < 0.001).Conclusions The OS of patients with thymic carcinoma depends on complete resection, but patients with MG also demonstrate improved prognoses. MG patients have higher rates of complete surgical resection, which may account for their better prognoses. Patients with MG have unique features that may aid in the clinical management of these patients.

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Section: Discussionmentioning

confidence: 99%

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Zhang

et al. 2015

Int J Clin Oncol

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“…The incidence of nodal metastases in these patients was 26.8% and 27.5%, respectively. A smaller study by Park et al 8 analyzed nodal metastases in 29 patients with thymic carcinoma who underwent nodal dissection and found that 20.8% of patients had pathologically confirmed nodal metastases.…”

mentioning

confidence: 99%

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Weksler

Holden

Sullivan

2015

Journal of Thoracic Oncology

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“…Some studies have shown the prognostic value of positive lymph nodes [10, 20, 21], while other studies found no difference in survival based on their presence [2]. Park et al reported that dissection of more than 10 lymph nodes is required to predict prognosis accurately [22]. Patients with anterior mediastinal lymph node involvement should have a better prognosis, considering that anterior mediastinal lymph nodes can be removed en bloc with the tumor in an extended thymectomy.…”

Section: Discussionmentioning

confidence: 99%

Stage IVb thymic carcinoma: patients with lymph node metastases have better prognoses than those with hematogenous metastases

et al. 2017

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BackgroundThis study aimed to analyze the pattern of lymphogenous and hematogenous metastases in patients with stage IVb thymic carcinomas and identify prognostic factors for their survivals.MethodsBetween September 1978 and October 2014, 68 patients with pathologically confirmed stage IVb thymic carcinomas were treated at Fudan University Shanghai Cancer Center. Forty-three patients had lymph node involvement without distant metastases, and the remaining 25 patients had hematogenous metastases. Clinical-pathological characteristics, including age, sex, histologic subtype, tumor size, metastasis, treatment modalities, such as surgical resection, radiotherapy, and chemotherapy, and clinical outcomes, such as overall survival (OS) and progression free survival (PFS), were analyzed.ResultsThe median follow-up time was 22 months (range, 1–126 months). The median OS of all patients with stage IVb thymic carcinomas was 30 months, and the 5-year overall survival rate was 25.1%. The median PFS was 11 months, and the 5-year PFS was 17.9%. Stage IVb patients with lymph node involvement had a better survival than those with distant metastasis (40 vs. 20 months, p = 0.002). Patients with myasthenia gravis had a worse prognosis (p = 0.033). Multivariate analysis identified metastatic status as an independent prognostic factor for OS in patients with stage IVb thymic carcinomas.ConclusionsPatients with lymph node involvement had a better survival than those with distant metastases. Much work remains to investigate the prognosis of patients with stage IVb thymic carcinomas and to explore different treatment strategies for patients with lymph node involvement and distant metastases.

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Importance of Lymph Node Dissection in Thymic Carcinoma

Cited by 37 publications

References 26 publications

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Thymic carcinoma patients with myasthenia gravis exhibit better prognoses

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Stage IVb thymic carcinoma: patients with lymph node metastases have better prognoses than those with hematogenous metastases

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