Abstract:Perioperative red blood cell transfusions are common. Antigen screening, performed via indirect Coombs test, is required prior to red blood cell transfusion. False-negative test results can lead to acute or delayed hemolytic transfusion reactions. This case report emphasizes the importance of using life-long alerts in a hospital's electronic medical record system for patients with positive antigen screening to prevent falsenegative preoperative antigen results from leading to hemolytic transfusion reactions.
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