Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases

Kıvanç, Tülay; Kulaksızoğlu, Sevsen; Lakadamyalı, Hatıce; Eyüboğlu, Füsun Öner

doi:10.1002/jcla.22199

Cited by 31 publications

(36 citation statements)

References 28 publications

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“…Some previous studies were done in mild to moderate OSA patients only (Kim et al, 2016;Koseoglu et al, 2015), while the present study and other studies were conducted in severe or moderate to severe OSA patients (Ryan, Taylor, & McNicholas, 2009). This correlation may also reflect a systemic inflammatory response to hypoxemia, which is known to trigger activation of neutrophils, platelet, IL-6, and hs-CRP (Calvin et al, 2009;Kim et al, 2016;Kivanc & Kulaksizoglu, 2017). These neutrophils and platelets in turn interact with the pro-inflammatory cytokines resulting in increases in NLR and PLR in patients with severe OSA (Kivanc & Kulaksizoglu, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…This correlation may also reflect a systemic inflammatory response to hypoxemia, which is known to trigger activation of neutrophils, platelet, IL-6, and hs-CRP (Calvin et al, 2009;Kim et al, 2016;Kivanc & Kulaksizoglu, 2017). These neutrophils and platelets in turn interact with the pro-inflammatory cytokines resulting in increases in NLR and PLR in patients with severe OSA (Kivanc & Kulaksizoglu, 2017). Nocturnal hypoxemia and sleep disturbances result in increases in IL-6 and hs-CRP (Kim et al, 2016;Shamsuzzaman et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…A complete blood cell count was performed on Coulter LH 780 series automated blood cell counter (Beckman Coulter, USA), Liver enzymes (AST, ALT) levels were collected on Cobas 6000 analyzer series (Roche diagnotics, Switzerland) and hs-CRP levels were performed on Cobas e411 analyzer series (Roche diagnotics, Switzerland). NLR and PLR were obtained from the absolute neutrophil and platelet counts, respectively, divided by the absolute lymphocyte counts (Kivanc & Kulaksizoglu, 2017). All samples were processed by technicians blinded to the samples.…”

Section: Biochemical Analysesmentioning

confidence: 99%

“…Several studies have examined relationships between hs-CRP, NLR, and PLR in OSA patients with different severities. Either significant increases in inflammation biomarkers (white blood cell count, WBC) (Calvin, Albuquerque, Lopez-Jimenez, & Somers, 2009), hs-CRP (Kim et al, 2016) and PLR (Kivanc & Kulaksizoglu et al, 2017) or no significant increase (Koseoglu et al, 2015) have been found in OSA patients.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, neutrophil to lymphocyte ratios (NLR) and platelet to lymphocyteratios (PLR) have emerged as potential new biomarkers that indicate the presence of systemic inflammation (Kivanc & Kulaksizoglu, 2017) as well as high sensitivity C-reactive protein (hs-CRP), which is an acute-phase protein that is generated in the liver (Kim et al, 2016). Several studies have examined relationships between hs-CRP, NLR, and PLR in OSA patients with different severities.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and Inflammation after Continuous Positive Airway Pressure Therapy in Patients with Severe Obstructive Sleep Apnea

Wuttiumporn¹,

Khrisanapant²,

Boonsawat³

et al. 2018

Sleep Hypn

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Background: It has been demonstrated that moderate to severe obstructive sleep apnea (OSA) leads to generation of reactive oxygen species and inflammation. We evaluated whether continuous positive airway pressure (CPAP) treatment progressively improves oxidative stress and inflammation, and whether an association exists in severe OSA patients between severity of OSA and biomarkers of oxidative stress and inflammation. Methods:Forty patients with severe OSA (apnea hypopnea index, AHI: 37.8 ± 5.8 /h) that were newly diagnosed using polysomnography were recruited. Patients received CPAP treatment for six months. Patients were assigned to CPAP and non-CPAP treatment groups in equal numbers. The levels of malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high sensitivity C-reactive protein (hs-CRP), neutrophils to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) were measured prior to and after three and six months of therapy. Results: AHI was positively correlated with MDA (r = 0.4728, p < 0.01), ALT (r = 0.6081, p < 0.001), AST (r = 0.6299, p < 0.001), NLR (r = 0.3943, p < 0.05), PLR (r = 0.3319, p < 0.05), and hs-CRP (r = 0.5728, p < 0.001). In the CPAP but not in non-CPAP treatment group, MDA, AST, NLR, PLR, and hs-CRP levels (p < 0.001), and ALT (p < 0.05) levels were improved after three and six months of treatment. After six months, MDA levels decreased further compared to MDA levels at three months, and this decrease was significant (p < 0.001). Conclusion: Our study demonstrates that CPAP therapy in severe OSA patients produces clinical benefits by improving oxidative stress and inflammation progressively, and that severity of OSA is correlated with oxidative stress and inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Biochemical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and Inflammation after Continuous Positive Airway Pressure Therapy in Patients with Severe Obstructive Sleep Apnea

Wuttiumporn¹,

Khrisanapant²,

Boonsawat³

et al. 2018

Sleep Hypn

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The association of hemocyte profile and obstructive sleep apnea

Fan

Lü

Hong

et al. 2018

Clinical Laboratory Analysis

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Background The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, the analysis of blood cell indexes of obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze the blood routine in OSA patients. Methods A retrospective study was conducted on 1087 male patients, who were admitted to the sleep center of Nanfang Hospital from May 2013 to February 2018. According to the apnea hypopnea index (AHI), patients were divided into four groups: control group (AHI < 5, n = 135), mild OSA (5 ≦ AHI < 15, n = 185), moderate OSA (15 ≦ AHI < 30, n = 171), and severe OSA (AHI ≧ 30, n = 596). Data collected included sleep parameters, complete blood routine, body mass index (BMI), age, and comorbidities. Results In our study, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocytes, hemoglobin, hematocrit, platelets, MPV, and PDW‐SD were statistically significant among the four groups based on AHI (P < 0.05), but no significant differences were found in MCV, RDW‐SD, N/L, and P/L ratio (P > 0.05). Neutrophils, lymphocytes, monocytes, eosinophils, basophils, hemoglobin, hematocrit, platelets, and MPV were significantly correlated with AHI. Moreover, multiple linear regression analysis demonstrated that hematocrit (β = 73.254, P = 0.001), neutrophils (β = 1.414, P = 0.012), and lymphocytes (β = 4.228, P < 0.001) were independently associated with AHI. Conclusion Neutrophils, lymphocytes, and hematocrit were independently associated with OSA severity. And combining these three blood cell indicators could contribute to the diagnosis of OSA.

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Plasma expression of HIF‐1α as novel biomarker for the diagnosis of obstructive sleep apnea‐hypopnea syndrome

Liu

Wang

Zhu

et al. 2020

Clinical Laboratory Analysis

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Background Obstructive sleep apnea‐hypopnea syndrome (OSAHS) is a common breathing disorder during sleep with potential lethality and multi‐complications. Polysomnography (PSG) is now the golden standard for the diagnosis obstructive sleep apnea‐hypopnea syndrome. However, PSG is expensive and time‐consuming. Therefore, it is important to find inexpensive and convenient biomarkers for the diagnosis of OSAHS. Objective The present study aimed to explore the potential diagnostic value of HIF‐1α for OSAHS and its clinical significance. Methods This study consisted of 368 patients admitted to the sleep laboratory. The patients were classified according to their apnea‐hypopnea index (AHI) scores as OSA negative (AHI < 5), mild‐moderate (AHI:5‐30), and severe OSA (AHI > 30), and severe OSA treated with continuous positive airway pressure (CPAP). qRT‐PCR was used to detect mRNA levels in the plasma; Pearson's correlation analysis was performed to analyze the correlation of HIF‐1α mRNA level and the clinicopathological factors of OSAHS; ROC curve was constructed to evaluate the diagnostic value of HIF‐1α mRNA. Results HIF‐1α mRNA was significantly up‐regulated in the plasma of OSAHS patients, especially patients with severe OSAHS. HIF‐1α mRNA was positively correlated with the AHI and ODI but negatively correlated with the mean oxygen saturation in patients with OSAHS. Results of ROC curve showed that HIF‐1α is a sensitive biomarker for the diagnosis of OSAHS, especially severe OSAHS. Conclusions HIF‐1α mRNA might be used as s a convenient and inexpensive method for triaging OSAHS patients PSG assessment in the hospital and evaluate the curative effect.

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Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases

Cited by 31 publications

References 28 publications

Oxidative Stress and Inflammation after Continuous Positive Airway Pressure Therapy in Patients with Severe Obstructive Sleep Apnea

Oxidative Stress and Inflammation after Continuous Positive Airway Pressure Therapy in Patients with Severe Obstructive Sleep Apnea

The association of hemocyte profile and obstructive sleep apnea

Plasma expression of HIF‐1α as novel biomarker for the diagnosis of obstructive sleep apnea‐hypopnea syndrome

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