Importance of IL-6, MMP-1, IGF-1, and BAX Levels in Lumbar Herniated Disks and Posterior Longitudinal Ligament in Patients with Sciatic Pain

Dağıstan, Yaşar; Çukur, Selma; Dağıstan, Emine; Gezici, Ali Rıza

doi:10.1016/j.wneu.2015.07.039

Cited by 13 publications

(14 citation statements)

References 48 publications

(45 reference statements)

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“…In line with this clinical study, Franson et al (19) reported that phospholipase A2 activity of herniated discs was increased compared to that of normal discs. Phospholipase A2 is a critical inflammatory enzyme that plays an important role in liberation of arachidonic acid from We also showed previously in another study that several inflammatory markers and cytokines were increased in herniated disc tissues (22). Our findings are in line with those of the previous studies in the literature (11,23).…”

Section: Discussionsupporting

confidence: 92%

Is there a link between lumbar disc herniation and haemogram parameters?

Kılınç¹,

Dağıstan²,

Dağıstan³

et al. 2017

Anadolu Kliniği Tıp Bilimleri Dergisi

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Aim: Inflammatory mechanisms play a key role in the pathogenesis of back pain related to disc hernia. Mean platelet volume (MPV) and red cell distribution width (RDW) are novel and promising inflammatory markers in routine hemogram tests. In this study, we aimed to compare the MPV and RDW values of patients with lumbar disc herniation (LDH) to those of healthy subjects and symptomatic patients suffering from sciatica without radiological evidence of lumbar disc herniation. Materials and Methods: This retrospective cohort study was carried out in the Neurosurgery Department of the Abant Izzet Baysal University Education and Research Hospital. Three groups as the controls (n=57) and LDH (n=73) and sciatica (n=20) groups were designed. Hemogram parameters including white blood cell count (WBC), hemoglobin (Hb), hematocrit (Htc), mean corpuscular volume (MCV), RDW, platelet count (PLT) and MPV were evaluated for each group. Results: The mean MPVs of the LDH, sciatica, and control groups were 9.3±1.8 fL, 8.2±1.1 fL, and 8.4±1.0 fL, respectively. The mean MPV was significantly higher for the LDH group, compared to the sciatica and control groups (p=0.001). The mean RDWs of the LDH, sciatica, and control groups were 14.8±1.8, 13.8±1.0, and 13.7±1.2, respectively. The mean RDW was also significantly higher for the LDH group in comparison to the sciatica and control groups (p=0.001). Discussion and Conclusion: We think that elevated MPV and RDW values might be strong indicators of LDH in patients with sciatica and that such patients should be prioritized for imaging studies. However, further prospective studies are needed to support our results.

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Section: Discussionsupporting

confidence: 92%

Is there a link between lumbar disc herniation and haemogram parameters?

Kılınç¹,

Dağıstan²,

Dağıstan³

et al. 2017

Anadolu Kliniği Tıp Bilimleri Dergisi

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“…Additionally, we determined a relationship also among ratios of Bax-positive cells IVD degeneration grades. Similarly to our results, Dagistan et al (6) reported that in…”

Section: █ Conclusionsupporting

confidence: 92%

The effects of polymorphisms of death pathway genes and mitochondrial pathway genes in intervertebral disc degeneration

Eser

Eser²,

Aslan³

et al. 2016

Turkish Neurosurgery

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“…Nevertheless, it has been reported that IGF1 may lead to hyperalgesia. Immunohistochemistry has shown that the expression of IGF1 is significantly increased in the intervertebral disc and posterior longitudinal ligament biopsy specimens of patients with sciatica …”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemistry has shown that the expression of IGF1 is significantly increased in the intervertebral disc and posterior longitudinal ligament biopsy specimens of patients with sciatica. 10 The inflammatory process and intact posterior longitudinal ligaments in patients can increase IGF levels. 10 Importantly, studies have also shown that increases in both IGF1 concentration and the IGF1: IGF-binding protein 3 ratio over the first 6 months of aromatase inhibitor treatment were significantly associated with the onset of or increase in musculoskeletal pain among breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…10 The inflammatory process and intact posterior longitudinal ligaments in patients can increase IGF levels. 10 Importantly, studies have also shown that increases in both IGF1 concentration and the IGF1: IGF-binding protein 3 ratio over the first 6 months of aromatase inhibitor treatment were significantly associated with the onset of or increase in musculoskeletal pain among breast cancer patients. 11 Among healthy older women, increasing IGF1 concentrations following administration of growth hormone was associated with a significant increase in the incidence of arthralgias.…”

Section: Discussionmentioning

confidence: 99%

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