Importance of hydrophobic interactions in the single-chained cationic surfactant-DNA complexation

López‐López, Manuel; López‐Cornejo, Pilar; Martı́n, Verónica; Ostos, Francisco José; Checa-Rodríguez, Cintia; Prados-Carvajal, Rosario; Lebrón, José Antonio; Huertas, Pablo; Moyá, Marı́a Luisa

doi:10.1016/j.jcis.2018.03.048

Cited by 44 publications

(34 citation statements)

References 48 publications

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“…Occurrence of positively charged fragments in amphiphilic scaffold is responsible for their attractiveness in nanotechnological applications as antimicrobial and bioimaging agents [5,6], corrosion inhibitors [7], supramolecular catalysts [8], stabilizers of nanoparticles and nanocarriers [9,10], and, especially as, drug and gene nanocarriers [11]. Cationic head groups of surfactants provide their high affinity toward biopolyanions, such as DNA [12,13], cell membranes, and intracellular organelles, such as mitochondrion, thereby initiating the development of perspective field of therapy, the so-called mitochondrion medicine [14,15]. Essential advantages of cationic surfactants are the diversity of their head groups allowing chemical modification and introduction of desirable moiety to answer the biotechnological criteria.…”

Section: Introductionmentioning

confidence: 99%

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

Zakharova

Pashirova

Doktorovová

et al. 2019

IJMS

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The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction.

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Section: Introductionmentioning

confidence: 99%

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

Zakharova

Pashirova

Doktorovová

et al. 2019

IJMS

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“…Cationic surfactants can condense high molecular DNA in solutions to produce nanosized particles [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. DNA condensation induced by a variety of agents is an important stage in gene delivery technique [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…DNA condensation induced by a variety of agents is an important stage in gene delivery technique [ 8 , 9 , 10 ]. The compact structures are typically observed in the excess of cationic surfactant in DNA solution at a sufficiently high charge ratio z (the number of positive groups of surfactants per a single DNA phosphate) [ 4 , 5 , 7 , 11 ]. The amphiphilic nature of surfactants causes their cooperative binding to DNA [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles

et al. 2018

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Cationic azobenzene-containing surfactants are capable of condensing DNA in solution with formation of nanosized particles that can be employed in gene delivery. The ratio of surfactant/DNA concentration and solution ionic strength determines the result of DNA-surfactant interaction: Complexes with a micelle-like surfactant associates on DNA, which induces DNA shrinkage, DNA precipitation or DNA condensation with the emergence of nanosized particles. UV and fluorescence spectroscopy, low gradient viscometry and flow birefringence methods were employed to investigate DNA-surfactant and surfactant-surfactant interaction at different NaCl concentrations, [NaCl]. It was observed that [NaCl] (or the Debye screening radius) determines the surfactant-surfactant interaction in solutions without DNA. Monomers, micelles and non-micellar associates of azobenzene-containing surfactants with head-to-tail orientation of molecules were distinguished due to the features of their absorption spectra. The novel data enabled us to conclude that exactly the type of associates (together with the concentration of components) determines the result of DNA-surfactant interaction. Predomination of head-to-tail associates at 0.01 M < [NaCl] < 0.5 M induces DNA aggregation and in some cases DNA precipitation. High NaCl concentration (higher than 0.8 M) prevents electrostatic attraction of surfactants to DNA phosphates for complex formation. DAPI dye luminescence in solutions with DNA-surfactant complexes shows that surfactant tails overlap the DNA minor groove. The addition of di- and trivalent metal ions before and after the surfactant binding to DNA indicate that the bound surfactant molecules are located on DNA in islets.

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“…When 50 mg mL À1 N-CDs was added, the zeta potential was 7.3 mV, and when the concentration of N-CDs was increased to 100 mg mL À1 , the zeta potential increased to 9.9 mV. This charge transfer may be due to the DNA condensation and compression caused by N-CDs binding to nucleic acids 30 and is driven by electrostatic interactions. These results suggested that there was electrostatic interaction between N-CDs and DNA.…”

Section: Dna Binding and Quenching On N-cdsmentioning

confidence: 98%

Insight into the DNA adsorption on nitrogen-doped positive carbon dots

Cai

Hao

et al. 2019

RSC Adv.

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Importance of hydrophobic interactions in the single-chained cationic surfactant-DNA complexation

Cited by 44 publications

References 48 publications

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles

Insight into the DNA adsorption on nitrogen-doped positive carbon dots

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