Importance of Helicobacter pylori eradcation for maintenance of remission of drug associated peptic ulcer disease

Dajani, Asad Izziddin; Dham, Ruwayda; Elsahhar, Medhat; Subeih, S; Sheikh, Salman; Mansour, Ahmed M. A.; El-Ebeidi, G; Mohammed, Sara A.; Horaibi, M El; Gawli, A Al; Alanzi, Abrar; Gautham, Sai; Ahmed, Ossama Ashraf; Hammour, Adnan M. Abu; Nounou, Mohamed Ismail; Al-Mardini, Hanan

doi:10.4103/1319-3767.27739

Cited by 2 publications

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“…Our sample consisted of a total of 7,829 patients, including both genders aged between 2 and 75 years. Studies from Egypt (n=18) [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] , Saudi Arabia (n=8) [46][47][48][49][50][51][52][53] , Lebanon (n=6) [54][55][56][57][58][59] , UAE (n=5) [60][61][62][63][64] , Iraq (n=3) [65][66][67] , Qatar (n=3) [68][69][70] , Algeria (n=2) 71,72 , Palestine (n=1) 73 , Morocco (n=1) 74 , Syria (n=1) 75 , Yemen (n=1) 76 Tunisia (n=1) 77 , Jordon (n=1) 54 , Sudan (n=1) …”

Section: Patients and Study Characteristicsmentioning

confidence: 99%

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Bahbah,

abu-Elfatth,

Alzamzamy

et al. 2023

Global Gastroenterology

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We conducted a systematic review and network meta-analysis (NMA) to estimate the efficacy of Helicobacter pylori (H. pylori) treatment strategies in Arab countries.Methods: We searched electronic databases from inception to July 18, 2020, using boolean operators. Search terms were (Helicobacter pylori R H. pylori OR pylori OR helicobacter). The risk of bias was assessed using Cochrane risk of bias tool. Retrieved articles were screened, and relevant data were extracted. We used R programming software to analyze extracted data.Results: Fifty-four articles (n= 7829 patients) were included in the NMA. Pooled analysis demonstrated that adjuvant therapy (standard triple or sequential therapy plus another adjuvant drug) was the best treatment with higher odds of eradication rate [OR= 6.42, 95% CI (1.37: 30.05), P-score= 0.21]. In naïve population, quinolones-based therapy (QBT) and sequential therapy (SQT) were associated with higher eradication rates than other regimens [

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Section: Patients and Study Characteristicsmentioning

confidence: 99%

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Bahbah,

abu-Elfatth,

Alzamzamy

et al. 2023

Global Gastroenterology

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show abstract

Section: Patients and Study Characteristicsmentioning

confidence: 99%

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Afify

Abd-ElGawad

Bahbah

et al. 2021

Preprint

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Purpose: We aimed to conduct an updated systematic review and network meta-analysis (NMA) to estimate the efficacy of Helicobacter pylori (H. pylori) treatment strategies in Arab countries. Methods: We systematically searched PubMed, Scopus, Web of Science (WOS), EBSCO, and EMBASE from inception to July 18, 2020, using boolean operators. Retrieved articles were screened, and relevant data were extracted. We used R programming software to analyze extracted data. Results: Fifty-four articles (n= 7829 patients) were included in the NMA. Pooled overall analysis demonstrated that adjuvant therapy (standard triple or sequential therapy plus another adjuvant drug) was the best treatment with higher odds of eradication rate [OR= 6.42, 95% CI (1.37: 30.05), P-score= 0.21]. Moreover, Seqential therapy (SQT) and Quinolone based therapy (QBT) were associated with higher eradication rate compared to other regimens [OR= 4.83, 95% CI (1.49: 15.64), P-score= 0.30] and [OR= 4.32, 95% CI (1.15: 16.16), P-score= 0.36], respectively. In adults, the efficacy of QBT was higher than other stratigies in terms of H. pylori eradication [OR= 2.00, 95% CI (1.09, 3.69), P score= 0.19]. In naïve population, QBT and SQT were associated with substantial eradication rate [OR= 1.94, 95% CI (1.19: 3.16), P score=0.19] and [OR= 1.66, 95% CI (1.10: 2.50), P score=0.33], respectively. Conclusion: Our findings suggest that standard triple or sequential therapy plus another adjuvant drug, QBT and SQT therapies were the most effective regimens for eradicating H.pylori in Arab countries.

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Importance of Helicobacter pylori eradcation for maintenance of remission of drug associated peptic ulcer disease

Cited by 2 publications

References 0 publications

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

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