Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation.

Rémy‐Jardin, Martine; Giraud, Frédéric; Rémy, Jacques; Copin, Marie‐Christine; Gosselin, B; Duhamel, Alain

doi:10.1148/radiology.189.3.8234692

Cited by 334 publications

(188 citation statements)

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“…However, the correlations between CAD and readers (extent of disease, extent of reticulation, coarseness) and PFTs (DL CO , FVC) were strengthened when the analyses were restricted to patients with minimal GGO (<15%). In collagen-vascular disorders, GGO may reflect inhomogeneous lung ventilation or perfusion as well as infiltrative (e.g., infectious) disease or drug toxicity [16,26,27]. GGO mixed with a reticular pattern is indicative of fine fibrosis below the spatial resolution of thin-section CT, particularly if traction bronchiolectasis is present within these areas (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…GGO mixed with a reticular pattern is indicative of fine fibrosis below the spatial resolution of thin-section CT, particularly if traction bronchiolectasis is present within these areas (Fig. 3) [26]. The diversity of causes of GGO may have contributed to the weak relationships between CAD and PFTs, CAD and the readers, as well as between the readers and PFTs in patients with extensive GGO.…”

Section: Discussionmentioning

confidence: 99%

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Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool

Marten¹,

Dicken

Kneitz

et al. 2008

Eur Radiol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool

Marten¹,

Dicken

Kneitz

et al. 2008

Eur Radiol

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“…Interstitial in Jardin et al [20], volume averaging of the tiny parenchymal cysts that characterize the microcystic honeycomb pattern may also lead to increased lung attenuation. In our study, nonspecific interstitial pneu monia with fibrosis was much more fre quently seen in female than in male patients (96% of patients were female).…”

Section: Ct Of Nonspecific Interstitial Pneumonia With Fibrosismentioning

confidence: 98%

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Kim¹,

Lee²,

Chung³

et al. 1998

American Journal of Roentgenology

163

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OBJECTIVE. The purposeof our studywas to describehigh-resolutionCT findingsof nonspecific interstitial pneumonia with fibrosis and to compare findings seen on CT with pathologic findings. MATERIALS AND METHODS. High-resolutionCT findingsof biopsy-provennonspecific interstitial pneumonia with fibrosis from 23 consecutive patients (one man and 22 women) were analyzed retrospectively by two chest radiologists. CT findings were compared with pathologic findings.RESULTS. The predominant high-resolution CT finding,seenin all patients,wasbilateral patchy areasof ground-glass opacity with (35%) or without (65%) areasof consolidation. Ir regular linear opacities (87%), thickening of bronchovascular bundles (65%), and bronchial dilatation (52%) were also frequently seen. Honeycombing was not seen in any patient. All parenchymal abnormalities showed subpleural predominance. Areas of ground-glass opacity with or without irregular linear opacity or bronchial dilatation on CT correspondedpathologi cally to areasof interstitial thickening causedby varying degreesof interstitial inflammation and fibrosisshowingtemporaluniformity.Areas of consolidation, seenat five biopsysites, represented the areas of bronchiolitis obliterans organizing pneumonia, foamy cell collections in alveolar spaces,or microscopic honeycombing with mucin stasis. CONCLUSION.On high-resolutionCT, nonspecificinterstitialpneumoniawith fibrosis is most commonly revealed as patchy subpleural areasof ground-glass opacity mixed with ir regular linear opacity or bronchial dilatation. These areas represent interstitial thickening caused by varying degrees of interstitial inflammation, fibrosis, or both.

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“…The finding of ground glass opacities does not universally connote reversible disease or alveolitis and is often fine reticulation below the threshold of CT detection [31]. The extent of ILD seen on HRCT does have prognostic significance.…”

Section: High Resolution Ctmentioning

confidence: 99%

Interstitial Lung Disease in Systemic Sclerosis: Diagnosis and Management

Schol

Carr²,

Frech³

et al. 2012

Rheumatology

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Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation.

Abstract: In patients with chronic diffuse infiltrative lung disease, areas of ground-glass attenuation not associated with traction bronchiectasis or bronchiolectasis are a reliable indicator of inflammation.

Cited by 334 publications

References 0 publications

Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool

Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Interstitial Lung Disease in Systemic Sclerosis: Diagnosis and Management

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