Importance of gold nanoparticles for detection of toxic heavy metal ions and vital role in biomedical applications

Dhumale, Vinayak A.; Gangwar, Rajesh K.; Pande, Nishigandh

doi:10.1080/14328917.2020.1825770

Cited by 12 publications

(6 citation statements)

References 96 publications

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“…As a result, alternative therapeutic approaches for microbial pathogens are required. Nanoparticles have vital biological uses, such as antibacterial, drug delivery, and bioimaging, because of their unique physicochemical characteristics, such as high specific surface area, optical properties, antimicrobial activity, catalytic activity, electronic properties, and magnetic properties [ 5 , 6 , 7 , 8 , 9 ]. Silver exhibits strong toxicity against a wide range of microbes (anti-bacterial applications).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Green Synthesis of Ag NPs for Extenuating Antimicrobial Resistance

et al. 2022

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Combating antimicrobial resistance (AMR) is an on-going global grand challenge, as recognized by several UN Sustainable Development Goals. Silver nanoparticles (Ag NPs) are well-known for their efficacy against antimicrobial resistance, and a plethora of green synthetic methodologies now exist in the literature. Herein, this review evaluates recent advances in biological approaches for Ag NPs, and their antimicrobial potential of Ag NPs with mechanisms of action are explored deeply. Moreover, short and long-term potential toxic effects of Ag NPs on animals, the environment, and human health are briefly discussed. Finally, we also provide a summary of the current state of the research and future challenges on a biologically mediated Ag-nanostructures-based effective platform for alleviating AMR.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Green Synthesis of Ag NPs for Extenuating Antimicrobial Resistance

et al. 2022

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“…The comparison of the summaries of functional groups for the Au nanoparticle systems are shown in Table S2. † The recorded 1 H NMR and FTIR spectral peaks could be tentatively attributed to various polyphenols and organic acids such as: gallic acid, citric acid, and avonoid glycosides from MC; 21 caffeic acid, p-coumaric acid, corosolic acid, gallic acid, 4hydroxybenzoic acid, kaempferol, ellagic acid, quercetin, 3-O-methylprotocatechuic acid, and isoquercitrin from LS, 28 and chlorogenic acid, gallic acid, and caffeic acid from MO. 29 Nanoparticle size and stability.…”

Section: Effects Of Leaf Extract Combinations On Au Nanoparticlesmentioning

confidence: 95%

“…This was conrmed upon the analysis of the Au-MCLS-1 spectrum. 1 H NMR spectral features were designated to organosulfur compounds such as alliin, S-allylcysteine, (E)-ajoene, (Z)-ajoene, and allicin. Alliin and S-allylcysteine, having quite similar hydrogen atoms in their structures, were considered to have similar peak features in 1 H NMR and were based on the research of Jayathilaka et al (2014).…”

Section: Effects Of Leaf Extract Combinations On Au Nanoparticlesmentioning

confidence: 99%

Localized surface plasmon resonance shift of biosynthesized and functionalized quasi-spherical gold nanoparticle systems

Raguindin

Mercado

2023

RSC Adv.

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“…These particles have been used in many technological applications, such as optoelectronics, nanoelectronics, and biological and chemical sensors, in addition to their biomedical applications in controlled drug delivery and release and bioimaging [20]. Moreover, gold NPs exhibit outstanding sensitivity and selectivity for the colorimetric identification of toxic heavy metal ions [21]. In this context, nanogram doses of gold NPs manifested potential activity against multidrug-resistant pathogens, as well as against Candida albicans; therefore, they were employed as a coating for medical devices [22].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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The main challenge for researchers in the biomedical sectors concerns the development of new active compounds through cost-effectiveness, rapid, simple, and ecofriendly methods to overcome antibiotic resistance to pathogenic microbes. Herein, gold nanoparticles (AuNPs) were fabricated by a green approach through the reduction of chloroauric acid (HAuCl4) by harnessing the metabolites present in the aqueous extract of Zingiber officinale rhizome. UV-Vis spectroscopy, FT-IR, XRD, TEM, DLS, and zeta potential were used to characterize phytosynthesized AuNPs. In addition, the antimicrobial effect was investigated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), unicellular fungi (Candida albicans), and multicellular fungi (Aspergillus brasiliensis). Antioxidant and in vitro cytotoxic activities were assessed. TEM and XRD showed the successful formation of spherical and crystalline structures, with sizes in the range of 5–53 nm (average size: 15.11 ± 8.5 nm). The zeta potential value (i.e., –28.8 mV) explains the high stability of synthesized AuNPs. AuNPs exhibit promising activity against prokaryotic and eukaryotic microorganisms with variable inhibition zones and low MIC values in the range of 25–6.25 µg mL−1. Phytosynthesized AuNPs exhibit DPPH scavenging activity with percentages of 87.6 ± 0.5% at a maximum concentration (1000 µg mL−1), which can be compared with ascorbic acid (97.3 ± 0.2%). Moreover, the AuNPs displayed a target-oriented effect for cancer cell lines HepG2 and MCF7 at low IC50 concentrations of 131.9 ± 9.34 and 288.23 ± 31.39 µg mL−1 compared to the normal oral epithelial OEC cell line (487.612 ± 3.53 µg mL−1). Overall, the phytosynthesized AuNPs show wide activities that enable their use in various biomedical and biotechnological applications.

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Importance of gold nanoparticles for detection of toxic heavy metal ions and vital role in biomedical applications

Cited by 12 publications

References 96 publications

Recent Advances in Green Synthesis of Ag NPs for Extenuating Antimicrobial Resistance

Recent Advances in Green Synthesis of Ag NPs for Extenuating Antimicrobial Resistance

Localized surface plasmon resonance shift of biosynthesized and functionalized quasi-spherical gold nanoparticle systems

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

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