Importance of Flavonoid as Secondary Metabolites

Mehta, Shuchi; Upadhyay, Sukirti; Rai, Gopal

doi:10.5772/intechopen.107462

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Oxidative stress plays a pivotal role in the pathogenesis of chronic kidney disease (CKD), highlighting the imbalance between reactive oxygen species (ROS) and antioxidant defenses, which initiates a cascade of renal tissue damage [ 14 , 15 ]. This stress can inflict damage on DNA, exacerbating conditions such as CKD.…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids, vital secondary metabolites within plants, exhibit a widespread presence across a plethora of botanical sources, including fruits, vegetables, herbs, stems, cereals, nuts, flowers, and seeds [ 13 , 14 , 15 ]. With over 10,000 distinct compounds identified to date, flavonoids showcase a remarkable diversity [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

View full text Add to dashboard Cite

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“…These are natural products derived from 2‐phenylchromen‐4‐one (flavone) (Katiyar et al, 2022). Today, flavonoids are regarded as a crucial component of nutraceutical, medicinal, and cosmetic preparations (Mehta et al, 2022; Panche et al, 2016). The biological activity of flavonoids has been the topic of extensive research in recent years, to the point where it even warranted a separate subject of study (Harnly, 2016).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen

Singh,

Kaur,

Chandra Arya

et al. 2023

Chem Biol Drug Des

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The increased prevalence of neurological illnesses is a burgeoning challenge to the public healthcare system and presents greater financial pressure. Formononetin, an O‐methylated isoflavone, has gained a lot of attention due to its neuroprotective potential explored in several investigations. Formononetin is widely found in legumes and several types of clovers including Trifolium pratense L., Astragalus membranaceus, Sophora tomentosa, etc. Formononetin modulates various endogenous mediators to confer neuroprotection. It prevents RAGE activation that results in the inhibition of neuronal damage via downregulating the level of ROS and proinflammatory cytokines. Furthermore, formononetin also increases the expression of ADAM‐10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. Besides these, formononetin also increases the expression of antioxidants, Nrf‐2, PI3K, ApoJ, and LRP1. Whereas, reduces the expression of p65‐NF‐κB and proinflammatory cytokines. It also inhibits the deposition of Aβ and MAO‐B activity. An inhibition of Aβ/RAGE‐induced activation of MAPK and NOX governs the protection elicited by formononetin against inflammatory and oxidative stress‐induced neuronal damage. Besides this, PI3K/Akt and ER‐α‐mediated activation of ADAM10, ApoJ/LRP1‐mediated clearance of Aβ, and MAO‐B inhibition‐mediated preservation of dopaminergic neurons integrity are the major modulations produced by formononetin. This review covers the biosynthesis of formononetin and key molecular pathways modulated by formononetin to confer neuroprotection.

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Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review

Jejurkar,

Chavan

2023

Futur J Pharm Sci

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Background Flavonoids are one of the crucial secondary metabolites as several functions are carried out by flavonoids, including regulating cell growth, luring insects and pollinators, and defending against biotic and abiotic stressors. They are found in fruits, whole grains, vegetables, spices, tea, wine, herbs, and seeds. More than 4000 flavonoid compounds have been discovered and extracted through different techniques. Most flavonoids are frequently utilized in pharmaceuticals, nutraceuticals, cosmetics, and other products. A flavonol glucoside called gossypin is the primary phytochemical of herbs that comes under the "Malvaceae" family and can be found in many species, including Hibiscus esculentus, Gossypium indicum, and Hibiscus vitifolius, all have it in their flowers. Gossypin shows not only significant pharmacological activities but also a defence mechanism and protects against pathogens, UV radiation, etc. It has drawn much interest from researchers and scholars due to its benefits of few adverse effects, high efficacy, and simple preparation. Thus, the current review focuses primarily on the pharmacological accounts of gossypin in various acute and chronic diseases. The various assays and animal studies conducted in the past supported gossypin effects as supporting the concept of the objective of the title. The review also highlights various patents filled on gossypin’s importance and current market scenario. Conclusion Therefore, the technical contents based on pharmacological activities, patents and current market scenario provided in this paper for the improvement of research in numerous scientific fields will be helpful to researchers for suitable alternative designs of gossypin in various disorders. Graphical abstract

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Importance of Flavonoid as Secondary Metabolites

Cited by 3 publications

References 20 publications

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen

Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review

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