Importance of evaluating for cow's milk allergy in pediatric surgical patients with functional bowel symptoms

Ikeda, Kayo; Ida, Shinobu; Kawahara, Hiroyuki; Kawamoto, Koji; Etani, Yuri; Kubota, Akio

doi:10.1016/j.jpedsurg.2011.09.028

Cited by 9 publications

(7 citation statements)

References 17 publications

(16 reference statements)

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“…Ikeda K et al [ 103 ] examined the effect of CMA on the management of 14 pediatric surgical patients in their institute, finding that a high LST index (normal range < 300%) was an important diagnostic tool for pediatric surgeons, who are in the front line for the treatment of neonates and infants with functional bowel symptoms.…”

Section: Igg Igg4 Allergen-specific Lymphocyte Stimulation Test mentioning

confidence: 99%

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

et al. 2021

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non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergen-specific lymphocyte stimulation test (ALST) and clinical score (CoMiss).

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Section: Igg Igg4 Allergen-specific Lymphocyte Stimulation Test mentioning

confidence: 99%

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

et al. 2021

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“…The IgE mediated form can be diagnosed by[1] raised IgE levels,[2] raised IgE levels specific to CM antigens otherwise known as IgE RAST,[3] stimulation index for CM by LST and[4] clinical response to the elimination of cow's milk. [8] In our patient, the IgE and RAST were very high and there was dramatic response to the elimination of cow's milk. Re-challenge with cow's milk has not been carried out due to the baby's clinical condition and the parents were unwilling.…”

Section: Discussionmentioning

confidence: 71%

“…It is postulated to occur due to the immature intestinal mucosal barrier being breached early in life, resulting in an exaggerated immune response. [8]…”

Section: Discussionmentioning

confidence: 99%

Neonatal segmental enteritis due to cow′s milk allergy

Arunachalam

Mathai

2013

J Indian Assoc Pediatr Surg

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Cow's milk protein allergy (CMPA) typically presents with persistent diarrhea or dysentery, vomiting and bleeding per rectum in young infants. CMPA is reported to mimic Hirschsprung's disease and malrotation. We report, a neonate who presented with recurrent attacks of segmental enteritis due to CMPA and the last episode presented with signs of peritonitis. He improved dramatically after elimination of cow's milk from his diet. CMPA should be considered in artificially fed babies with surgical abdomen and atypical clinical signs and symptoms.

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“…Refractory esophageal stricture (RES) refers to those that do not respond to repeated dilations, which may be attributed to food allergy. There have been reports that cow’s milk protein allergy may develop after gastrointestinal surgeries or injuries, possibly due to a disruption of the mucosal barrier [3,4,5]. We speculated that genetic susceptibility contributes to the development of food allergy in children with RES.…”

Section: Introductionmentioning

confidence: 94%

Novel Genetic Variants Associated with Child Refractory Esophageal Stricture with Food Allergy by Exome Sequencing

et al. 2017

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Background: Refractory esophageal stricture (RES) may be attributed to food allergy. Its etiology and pathogenesis are not fully understood. Identification of novel genetic variants associated with this disease by exome sequencing (exome-seq) may provide new mechanistic insights and new therapeutic targets. Methods: To identify new and novel disease-associating variants, whole-exome sequencing was performed on an Illumina NGS platform in three children with RES as well as food allergy. Results: A total of 91,024 variants were identified. By filtering out ‘normal variants’ against those of the 1000 Genomes Project, we identified 12,741 remaining variants which are potentially associated with RES plus food allergy. Among these variants, there are 11,539 single nucleotide polymorphisms (SNPs), 627 deletions, 551 insertions and 24 mixture variants. These variants are located in 1370 genes. They are enriched in biological processes or pathways such as cell adhesion, digestion, receptor metabolic process, bile acid transport and the neurological system. By the PubMatrix analysis, 50 out of the top 100 genes, which contain most variants, have not been previously associated with any of the 17 allergy-associated diseases. These 50 genes represent newly identified allergy-associated genes. Those variants of 627 deletions and 551 insertions have also not been reported before in RES with food allergy. Conclusions: Exome-seq is potentially a powerful tool to identify potential new biomarkers for RES with food allergy. This study has identified a number of novel genetic variants, opening new avenues of research in RES plus food allergy. Additional validation in larger and different patient populations and further exploration of the underlying molecular mechanisms are warranted.

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Importance of evaluating for cow's milk allergy in pediatric surgical patients with functional bowel symptoms

Cited by 9 publications

References 17 publications

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

Neonatal segmental enteritis due to cow′s milk allergy

Novel Genetic Variants Associated with Child Refractory Esophageal Stricture with Food Allergy by Exome Sequencing

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