Importance of duodenogastric reflux in gastro-oesophageal reflux disease

Fein, Martin; Maroske, J.; Kh, Fuchs

doi:10.1002/bjs.5486

Cited by 32 publications

(22 citation statements)

References 32 publications

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“…In our study, the overall gastric and esophageal bilirubin exposure was significantly increased both in patients with and without previous cholecystectomy in comparison with healthy subjects. This has been shown for a subgroup of our patients with GERD [8].…”

Section: Discussionsupporting

confidence: 51%

“…Esophageal exposure to bile is related both to the amount of DGR and gastroesophageal reflux [8]. Differences in the amount of gastroesophageal reflux are likely to be responsible for the observation that the effects on DGR were not detectable for esophageal bilirubin exposure.…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, GERD in patients without previous surgery is also associated with increased bile reflux [8]. Based on this background, gastric and esophageal bilirubin monitoring was analyzed in a large cohort of patients with upper gastrointestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Cholecystectomy on Gastric and Esophageal Bile Reflux in Patients with Upper Gastrointestinal Symptoms

et al. 2007

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Epidemiologic data have shown that cholecystectomy is associated with a moderately increased risk of esophageal adenocarcinoma. The study objective was to evaluate the role of refluxed bile. A total of 696 patients with upper gastrointestinal symptoms were included in the study, of whom 55 had a history of cholecystectomy (CHE). Bilirubin exposure was measured in percent time above absorbance 0.25 in the stomach and above 0.14 in the esophagus. Total gastric and esophageal bilirubin exposure was similar in both groups. Supine gastric bile reflux was slightly increased after cholecystectomy (30.6 +/- 30.2 vs. CHE: 37.1 +/- 29.5, P < 0.05). In patients with erosive esophagitis or Barrett's esophagus, there were differences in total gastric exposure (24.3 +/- 22.6 vs. CHE: 36.7 +/- 26.8, P < 0.05) but not in esophageal exposure. Cholecystectomy slightly augments bile reflux into the stomach without detectable differences in the esophagus. Therefore, increased esophageal bile reflux following cholecystectomy as a potential cause for the associated cancer risk could not be substantiated.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 95%

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Effect of Cholecystectomy on Gastric and Esophageal Bile Reflux in Patients with Upper Gastrointestinal Symptoms

et al. 2007

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“…Results Sixty-six patients underwent Barrett's ablation. The median length of the Barrett's esophagus was 3 (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14] cm. Twelve patients (18%) had high-grade dysplasia.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with Barrett's esophagus are at a higher risk of developing adenocarcinoma of the esophagus and gastric cardia [2]. The pathophysiology of Barrett's esophagus is related to pathologic reflux of acidic gastric contents exacerbated by bile [3,4]. Because of this, attempts to reduce this risk have centered on aggressive acid suppression, control of acid and bile reflux with an antireflux operation, or combining these two options with ablation of the Barrett's metaplasia [5][6][7].…”

Section: Introductionmentioning

confidence: 99%