Importance of donor history of restless leg syndrome and pica to asses iron deficiency

Singh, Ashutosh; Chaudhary, Rajendra; Sonker, Atul; Pandey, Hem Chandra

doi:10.1016/j.transci.2015.09.002

Cited by 9 publications

(12 citation statements)

References 9 publications

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“…In three of nine studies, including a randomized controlled trial, an association was found between RLS and iron deficiency or blood donation . RLS was more common in iron‐deficient or iron‐depleted donors (ferritin <20 μg/L and < 30 μg/L in women and men, respectively), with an RLS prevalence of 16% in iron‐deficient or ‐depleted donors and 11% in iron‐replete donors .…”

Section: Resultsmentioning

confidence: 98%

“…In only two studies there was a low risk of reporting bias; the risk in other studies was unclear. Overall, the quality of the studies was medium to high, except one …”

Section: Resultsmentioning

confidence: 98%

“…Eleven studies adequately described the characteristics of the population of which the participants were selected (Table ). One study did not describe the population base and the main characteristics of the study population . The main characteristics were sufficiently, but not in full detail, described in three studies .…”

Section: Resultsmentioning

confidence: 99%

“…The main characteristics were sufficiently, but not in full detail, described in three studies . The method of the measurement for the consequence of iron deficiency was described adequately in all articles, although not in full detail in five studies . The method and timing for determining the iron status was completely missing in one study, where an association between RLS and number of previous donations was made instead of the association with iron status.…”

Section: Resultsmentioning

confidence: 99%

“…RLS was measured in nine studies, using several validated questionnaires: the RLS diagnostic index questionnaire, the Cambridge‐Hopkins ascertainment questionnaire for RLS (CH‐RLSq), questionnaire of the International RLS study group and also self‐developed not validated questionnaires or interviews (Table ) …”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Iron deficiency–related symptoms in whole blood donors: a systematic review

et al. 2019

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Section: Resultsmentioning

confidence: 98%

“…In only two studies there was a low risk of reporting bias; the risk in other studies was unclear. Overall, the quality of the studies was medium to high, except one …”

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Iron deficiency–related symptoms in whole blood donors: a systematic review

et al. 2019

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Good Sleep as an Important Pillar for a Healthy Life

Moosavi-Movahedi

Yousefi

2021

University of Tehran Science and Humanities Series

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High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial

et al. 2020

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Introduction: Frequent blood donation often leads to iron deficiency and even anemia but appropriate strategies for detection and prevention are currently not mandatory. At the Medical University of Graz, we conducted a single-center prospective clinical trial to compare oral and IV iron supplementation in iron deficient blood donors including Austrian regular whole blood and platelet apheresis donors. We aimed to determine the difference of transferrin saturation between the treatment groups 8e12 weeks iron administration besides other parameters of iron status and blood count. Methods: 176 healthy male and female blood donors with iron deficiency (ferritin 30 ng/mL) were randomized to either a single dose of IV ferric carboxymaltose (1000 mg, n ¼ 86) or oral iron (II)fumarate (100 tablets of 100 mg [10 per week], n ¼ 90). Results: Between 2014 and 2016, 172 donors (137 women) completed the study; 4 in the oral group were lost to follow-up. At follow-up, median (IQR) transferrin saturation and ferritin were significantly higher in the intravenous group (27 [23e35]%, vs 21.0 [16e32]%; p < 0.001 and 105 [75e145] ng/mL vs 25 [17 e34] ng/mL; p < 0.001, respectively) while median (IQR) hemoglobin levels were comparable (IV, 13.6 [13.0e14.4] g/dL vs oral, 13.6 [13.0e14.2] g/dL). The frequency of adverse effects was comparable (38% in both groups) and no serious adverse events occurred. Conclusions: A single dose of 1000 mg of intravenous iron is highly effective to counteract iatrogenic iron deficiency in blood donors. Oral iron appears to be an acceptable alternative. The assessment of body iron stores should play a key role in maintaining blood donors' health. This trial was registered at www.clinicaltrials.gov as NCT01787526 on February 8, 2013 and at www. clinicaltrialsregister.eu (EudraCT identifier: 2013-000327-14) on September 24, 2013.

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Importance of donor history of restless leg syndrome and pica to asses iron deficiency

Cited by 9 publications

References 9 publications

Iron deficiency–related symptoms in whole blood donors: a systematic review

Iron deficiency–related symptoms in whole blood donors: a systematic review

Good Sleep as an Important Pillar for a Healthy Life

High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial

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