Importance of different region‐of‐interest protocols for the apparent diffusion coefficient measurement of tumors in diffusion‐weighted magnetic resonance imaging

Diffusion‐weighted quantitative MRI of pleural abnormalities: Intra‐ and interobserver variability in the apparent diffusion coefficient measurements

“…Several studies have shown the ability of quantitative DW‐MRI to characterize benign and malignant disease in different organs and compartments . However, several factors, which include also the manual method of region‐of‐interest (ROI) positioning for measuring the ADC, affect the measurement and can lead to unreliable values . Indeed, some investigators have found significant differences in ADC values by using different ROI methods in the same tumor, suggesting that the method of measurement significantly affects the ADC …”

“…[6][7][8][9][10][11] However, several factors, which include also the manual method of region-of-interest (ROI) positioning for measuring the ADC, affect the measurement and can lead to unreliable values. 2,3,[12][13][14][15][16][17][18][19] Indeed, some investigators have found significant differences in ADC values by using different ROI methods in the same tumor, suggesting that the method of measurement significantly affects the ADC. 20,21 Few recent studies have explored the usefulness of ADC measurements in the assessment of pleura with DW-MRI.…”