Importance of D1 receptors for associative components of amphetamine-induced behavioral sensitization and conditioned activity: a study using D1 receptor knockout mice

McDougall, Sanders A.; Reichel, Carmela M.; Cyr, Michelle C.; Karper, Patrick E.; Nazarian, Arbi; Crawford, Cynthia A.

doi:10.1007/s00213-005-0146-9

Cited by 21 publications

(16 citation statements)

References 71 publications

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“…Cocaine and amphetamine, which exhibit primary effects via inhibition of the DAT and NET, do not increase activity in drd1 KO mice (Crawford et al, 1997;Miner et al, 1995), although conflicting reports exist (McDougall et al, 2005). In these studies, modafinil did not increase the activity in male dopamine drd1 receptor KO mice, nor rearing in female dopamine drd1 receptor KO mice.…”

Section: Discussionmentioning

confidence: 74%

Dopamine Receptor Mediation of the Exploratory/Hyperactivity Effects of Modafinil

Young

Kooistra

Geyer

2011

Neuropsychopharmacol

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Modafinil (2-((diphenylmethyl)sulfinyl)acetamide) is described as an atypical stimulant and is a putative cognition enhancer for schizophrenia, but the precise mechanisms of action remain unclear. Receptor knockout (KO) mice offer an opportunity to identify receptors that contribute to a drug-induced effect. Here we examined the effects of modafinil on exploration in C57BL/6J mice, in dopamine drd1, drd2, drd3, and drd4 wild-type (WT), heterozygous (HT), and KO mice, and in 129/SJ mice pretreated with the drd1 antagonist SCH23390 using a cross-species test paradigm based on the behavioral pattern monitor. Modafinil increased activity, specific exploration (rearing), and the smoothness of locomotor paths (reduced spatial d) in C57BL/6J and 129/SJ mice (increased holepoking was also observed in these mice). These behavioral profiles are similar to that produced by the dopamine transporter inhibitor GBR12909. Modafinil was ineffective at increasing activity in male drd1 KOs, rearing in female drd1 KOs, or reducing spatial d in all drd1 KOs, but produced similar effects in drd1 WT and HT mice as in C57BL/6J mice. Neither dopamine drd2 nor drd3 mutants attenuated modafinil-induced effects. Drd4 mutants exhibited a genotype dose-dependent attenuation of modafinil-induced increases in specific exploration. Furthermore, the drd1 KO effects were largely supported by the SCH23390 study. Thus, the dopamine drd1 receptor appears to exert a primary role in modafinil-induced effects on spontaneous exploration, whereas the dopamine drd4 receptor appears to be important for specific exploration. The modafinil-induced alterations in exploratory behavior may reflect increased synaptic dopamine and secondary actions mediated by dopamine drd1 and drd4 receptors.

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Section: Discussionmentioning

confidence: 74%

Dopamine Receptor Mediation of the Exploratory/Hyperactivity Effects of Modafinil

Young

Kooistra

Geyer

2011

Neuropsychopharmacol

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“…When only a single pretreatment injection of cocaine is administered, qualitative differences between young and adult rats emerge. Specifically, adult rats and mice do not exhibit context-independent behavioral sensitization when cocaine is administered just once in the home cage (Drew and Glick 1989;Weiss et al 1989;Fontana et al 1993;Jackson and Nutt 1993;Battisti et al 1999Battisti et al , 2000McDougall et al 2005McDougall et al , 2007, whereas young rats show a robust sensitized response in the same circumstance (Fig. 1).…”

Section: Discussionmentioning

confidence: 98%

Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity

et al. 2008

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“…More specifically, rats given a single environment-cocaine pairing on PD 79 exhibited an elevated locomotor response when injected with saline in the same environmental context on PD 100. Such findings are not unique in the literature, because adult wild-type C57BL/6 mice show a strong conditioned locomotor response when tested 17 days after a single environment-amphetamine pairing (McDougall et al , 2005). An interesting effect often observed in drug-seeking tasks is called “incubation of drug craving,” in which cocaine-paired cues induce greater levels of instrumental responding at longer drug abstinence intervals (for reviews, see Lu et al , 2004; Pickens et al , 2011).…”

Section: Discussionmentioning

confidence: 99%

Age-dependent differences in the strength and persistence of psychostimulant-induced conditioned activity in rats

McDougall

Pipkin

Der-Ghazarian

et al. 2014

Behavioural Pharmacology

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The purpose of the present study was to determine the strength and persistence of cocaine-induced conditioned activity in young and adult rats. A one-trial protocol has proven useful for studying the ontogeny of psychostimulant-induced behavioral sensitization; therefore, a similar procedure was used to examine conditioned activity. On postnatal day (PD) 19 or PD 80, rats were injected with saline or cocaine in either a novel test chamber or the home cage. After various drug abstinence intervals (1–21 days), rats were injected with saline and returned to the test chamber, where conditioned activity was assessed. In a separate experiment, we examined whether cocaine-induced conditioned activity was a consequence of Pavlovian conditioning or a failure to habituate to the test environment. The results showed that adult rats exhibited strong one-trial conditioned activity that persisted for at least 21 days, whereas young rats did not show a conditioned locomotor response. The conditioned activity exhibited by adult rats did not result from a failure to habituate to the cocaine-paired environment. These results indicate that cocaine-paired contextual stimuli differentially affect behavior depending on age of the animal. The data provided by adult rats have potential translational relevance for humans because a single environment-drug pairing caused long-term alterations in behavior.

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Importance of D1 receptors for associative components of amphetamine-induced behavioral sensitization and conditioned activity: a study using D1 receptor knockout mice

Cited by 21 publications

References 71 publications

Dopamine Receptor Mediation of the Exploratory/Hyperactivity Effects of Modafinil

Dopamine Receptor Mediation of the Exploratory/Hyperactivity Effects of Modafinil

Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity

Age-dependent differences in the strength and persistence of psychostimulant-induced conditioned activity in rats

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